Skip to main content
PMC home page
Transactions of the American Clinical and Climatological Association logoLink to Transactions of the American Clinical and Climatological Association
. 2000;111:146–157.

A transgenic mouse model of steatosis and hepatocellular carcinoma associated with chronic hepatitis C virus infection in humans.

S M Lemon 1, H Lerat 1, S A Weinman 1, M Honda 1
PMCID: PMC2194357  PMID: 10881339

Full text

PDF
148

Images in this article

149Fig. 1
on p.149
151Fig. 2
on p.151

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alter H. J., Purcell R. H., Holland P. V., Popper H. Transmissible agent in non-A, non-B hepatitis. Lancet. 1978 Mar 4;1(8062):459–463. doi: 10.1016/s0140-6736(78)90131-9. [DOI] [PubMed] [Google Scholar]
  2. Alter M. J., Margolis H. S., Krawczynski K., Judson F. N., Mares A., Alexander W. J., Hu P. Y., Miller J. K., Gerber M. A., Sampliner R. E. The natural history of community-acquired hepatitis C in the United States. The Sentinel Counties Chronic non-A, non-B Hepatitis Study Team. N Engl J Med. 1992 Dec 31;327(27):1899–1905. doi: 10.1056/NEJM199212313272702. [DOI] [PubMed] [Google Scholar]
  3. Alter M. J., Mast E. E., Moyer L. A., Margolis H. S. Hepatitis C. Infect Dis Clin North Am. 1998 Mar;12(1):13–26. doi: 10.1016/s0891-5520(05)70405-0. [DOI] [PubMed] [Google Scholar]
  4. Barba G., Harper F., Harada T., Kohara M., Goulinet S., Matsuura Y., Eder G., Schaff Z., Chapman M. J., Miyamura T. Hepatitis C virus core protein shows a cytoplasmic localization and associates to cellular lipid storage droplets. Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1200–1205. doi: 10.1073/pnas.94.4.1200. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Chen C. M., You L. R., Hwang L. H., Lee Y. H. Direct interaction of hepatitis C virus core protein with the cellular lymphotoxin-beta receptor modulates the signal pathway of the lymphotoxin-beta receptor. J Virol. 1997 Dec;71(12):9417–9426. doi: 10.1128/jvi.71.12.9417-9426.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Choo Q. L., Kuo G., Weiner A. J., Overby L. R., Bradley D. W., Houghton M. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome. Science. 1989 Apr 21;244(4902):359–362. doi: 10.1126/science.2523562. [DOI] [PubMed] [Google Scholar]
  7. Czaja A. J., Carpenter H. A., Santrach P. J., Moore S. B. Host- and disease-specific factors affecting steatosis in chronic hepatitis C. J Hepatol. 1998 Aug;29(2):198–206. doi: 10.1016/s0168-8278(98)80004-4. [DOI] [PubMed] [Google Scholar]
  8. Di Bisceglie A. M., Martin P., Kassianides C., Lisker-Melman M., Murray L., Waggoner J., Goodman Z., Banks S. M., Hoofnagle J. H. Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med. 1989 Nov 30;321(22):1506–1510. doi: 10.1056/NEJM198911303212204. [DOI] [PubMed] [Google Scholar]
  9. Di Bisceglie A. M., Simpson L. H., Lotze M. T., Hoofnagle J. H. Development of hepatocellular carcinoma among patients with chronic liver disease due to hepatitis C viral infection. J Clin Gastroenterol. 1994 Oct;19(3):222–226. doi: 10.1097/00004836-199410000-00011. [DOI] [PubMed] [Google Scholar]
  10. Gale M., Jr, Kwieciszewski B., Dossett M., Nakao H., Katze M. G. Antiapoptotic and oncogenic potentials of hepatitis C virus are linked to interferon resistance by viral repression of the PKR protein kinase. J Virol. 1999 Aug;73(8):6506–6516. doi: 10.1128/jvi.73.8.6506-6516.1999. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Goodman Z. D., Ishak K. G. Histopathology of hepatitis C virus infection. Semin Liver Dis. 1995 Feb;15(1):70–81. doi: 10.1055/s-2007-1007264. [DOI] [PubMed] [Google Scholar]
  12. Hayashi N., Higashi H., Kaminaka K., Sugimoto H., Esumi M., Komatsu K., Hayashi K., Sugitani M., Suzuki K., Tadao O. Molecular cloning and heterogeneity of the human hepatitis C virus (HCV) genome. J Hepatol. 1993;17 (Suppl 3):S94–107. doi: 10.1016/s0168-8278(05)80432-5. [DOI] [PubMed] [Google Scholar]
  13. Honda M., Ping L. H., Rijnbrand R. C., Amphlett E., Clarke B., Rowlands D., Lemon S. M. Structural requirements for initiation of translation by internal ribosome entry within genome-length hepatitis C virus RNA. Virology. 1996 Aug 1;222(1):31–42. doi: 10.1006/viro.1996.0395. [DOI] [PubMed] [Google Scholar]
  14. Hourigan L. F., Macdonald G. A., Purdie D., Whitehall V. H., Shorthouse C., Clouston A., Powell E. E. Fibrosis in chronic hepatitis C correlates significantly with body mass index and steatosis. Hepatology. 1999 Apr;29(4):1215–1219. doi: 10.1002/hep.510290401. [DOI] [PubMed] [Google Scholar]
  15. Kawamura T., Furusaka A., Koziel M. J., Chung R. T., Wang T. C., Schmidt E. V., Liang T. J. Transgenic expression of hepatitis C virus structural proteins in the mouse. Hepatology. 1997 Apr;25(4):1014–1021. doi: 10.1002/hep.510250437. [DOI] [PubMed] [Google Scholar]
  16. Kiyosawa K., Furuta S. Hepatitis C virus and hepatocellular carcinoma. Curr Stud Hematol Blood Transfus. 1994;(61):98–120. doi: 10.1159/000423271. [DOI] [PubMed] [Google Scholar]
  17. Kiyosawa K., Sodeyama T., Tanaka E., Gibo Y., Yoshizawa K., Nakano Y., Furuta S., Akahane Y., Nishioka K., Purcell R. H. Interrelationship of blood transfusion, non-A, non-B hepatitis and hepatocellular carcinoma: analysis by detection of antibody to hepatitis C virus. Hepatology. 1990 Oct;12(4 Pt 1):671–675. doi: 10.1002/hep.1840120409. [DOI] [PubMed] [Google Scholar]
  18. Koike K., Moriya K., Ishibashi K., Matsuura Y., Suzuki T., Saito I., Iino S., Kurokawa K., Miyamura T. Expression of hepatitis C virus envelope proteins in transgenic mice. J Gen Virol. 1995 Dec;76(Pt 12):3031–3038. doi: 10.1099/0022-1317-76-12-3031. [DOI] [PubMed] [Google Scholar]
  19. Major M. E., Feinstone S. M. The molecular virology of hepatitis C. Hepatology. 1997 Jun;25(6):1527–1538. doi: 10.1002/hep.510250637. [DOI] [PubMed] [Google Scholar]
  20. Matsumoto M., Hsieh T. Y., Zhu N., VanArsdale T., Hwang S. B., Jeng K. S., Gorbalenya A. E., Lo S. Y., Ou J. H., Ware C. F. Hepatitis C virus core protein interacts with the cytoplasmic tail of lymphotoxin-beta receptor. J Virol. 1997 Feb;71(2):1301–1309. doi: 10.1128/jvi.71.2.1301-1309.1997. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. McHutchison J. G., Gordon S. C., Schiff E. R., Shiffman M. L., Lee W. M., Rustgi V. K., Goodman Z. D., Ling M. H., Cort S., Albrecht J. K. Interferon alfa-2b alone or in combination with ribavirin as initial treatment for chronic hepatitis C. Hepatitis Interventional Therapy Group. N Engl J Med. 1998 Nov 19;339(21):1485–1492. doi: 10.1056/NEJM199811193392101. [DOI] [PubMed] [Google Scholar]
  22. McPherson C. E., Shim E. Y., Friedman D. S., Zaret K. S. An active tissue-specific enhancer and bound transcription factors existing in a precisely positioned nucleosomal array. Cell. 1993 Oct 22;75(2):387–398. doi: 10.1016/0092-8674(93)80079-t. [DOI] [PubMed] [Google Scholar]
  23. Moriya K., Fujie H., Shintani Y., Yotsuyanagi H., Tsutsumi T., Ishibashi K., Matsuura Y., Kimura S., Miyamura T., Koike K. The core protein of hepatitis C virus induces hepatocellular carcinoma in transgenic mice. Nat Med. 1998 Sep;4(9):1065–1067. doi: 10.1038/2053. [DOI] [PubMed] [Google Scholar]
  24. Moriya K., Yotsuyanagi H., Shintani Y., Fujie H., Ishibashi K., Matsuura Y., Miyamura T., Koike K. Hepatitis C virus core protein induces hepatic steatosis in transgenic mice. J Gen Virol. 1997 Jul;78(Pt 7):1527–1531. doi: 10.1099/0022-1317-78-7-1527. [DOI] [PubMed] [Google Scholar]
  25. Pasquinelli C., Shoenberger J. M., Chung J., Chang K. M., Guidotti L. G., Selby M., Berger K., Lesniewski R., Houghton M., Chisari F. V. Hepatitis C virus core and E2 protein expression in transgenic mice. Hepatology. 1997 Mar;25(3):719–727. doi: 10.1002/hep.510250338. [DOI] [PubMed] [Google Scholar]
  26. Ray R. B., Lagging L. M., Meyer K., Ray R. Hepatitis C virus core protein cooperates with ras and transforms primary rat embryo fibroblasts to tumorigenic phenotype. J Virol. 1996 Jul;70(7):4438–4443. doi: 10.1128/jvi.70.7.4438-4443.1996. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Ray R. B., Meyer K., Ray R. Suppression of apoptotic cell death by hepatitis C virus core protein. Virology. 1996 Dec 15;226(2):176–182. doi: 10.1006/viro.1996.0644. [DOI] [PubMed] [Google Scholar]
  28. Ray R. B., Meyer K., Steele R., Shrivastava A., Aggarwal B. B., Ray R. Inhibition of tumor necrosis factor (TNF-alpha)-mediated apoptosis by hepatitis C virus core protein. J Biol Chem. 1998 Jan 23;273(4):2256–2259. doi: 10.1074/jbc.273.4.2256. [DOI] [PubMed] [Google Scholar]
  29. Ruggieri A., Harada T., Matsuura Y., Miyamura T. Sensitization to Fas-mediated apoptosis by hepatitis C virus core protein. Virology. 1997 Mar 3;229(1):68–76. doi: 10.1006/viro.1996.8420. [DOI] [PubMed] [Google Scholar]
  30. Sakamuro D., Furukawa T., Takegami T. Hepatitis C virus nonstructural protein NS3 transforms NIH 3T3 cells. J Virol. 1995 Jun;69(6):3893–3896. doi: 10.1128/jvi.69.6.3893-3896.1995. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Seeff L. B., Buskell-Bales Z., Wright E. C., Durako S. J., Alter H. J., Iber F. L., Hollinger F. B., Gitnick G., Knodell R. G., Perrillo R. P. Long-term mortality after transfusion-associated non-A, non-B hepatitis. The National Heart, Lung, and Blood Institute Study Group. N Engl J Med. 1992 Dec 31;327(27):1906–1911. doi: 10.1056/NEJM199212313272703. [DOI] [PubMed] [Google Scholar]
  32. Seeff L. B. Natural history of hepatitis C. Hepatology. 1997 Sep;26(3 Suppl 1):21S–28S. doi: 10.1002/hep.510260704. [DOI] [PubMed] [Google Scholar]
  33. Tabor E., Gerety R. J., Drucker J. A., Seeff L. B., Hoofnagle J. H., Jackson D. R., April M., Barker L. F., Pineda-Tamondong G. Transmission of non-A, non-B hepatitis from man to chimpanzee. Lancet. 1978 Mar 4;1(8062):463–466. doi: 10.1016/s0140-6736(78)90132-0. [DOI] [PubMed] [Google Scholar]
  34. Zhu N., Khoshnan A., Schneider R., Matsumoto M., Dennert G., Ware C., Lai M. M. Hepatitis C virus core protein binds to the cytoplasmic domain of tumor necrosis factor (TNF) receptor 1 and enhances TNF-induced apoptosis. J Virol. 1998 May;72(5):3691–3697. doi: 10.1128/jvi.72.5.3691-3697.1998. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Transactions of the American Clinical and Climatological Association are provided here courtesy of American Clinical and Climatological Association

RESOURCES