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. 1982 Apr;150(1):113–121. doi: 10.1128/jb.150.1.113-121.1982

Recombination between two IS/s flanking the r-determinant of R100-1: involvement of dor and recA gene functions in Salmonella typhimurium.

H Watanabe, K Mise, H Hashimoto
PMCID: PMC220089  PMID: 6277859

Abstract

Drug resistance genes of the r-determinant component of a composite R plasmid R100-1 were frequently lost in Salmonella typhimurium. Various deletion mutants were analyzed by restriction endonuclease cleavage, Southern blotting, and hybridization techniques. The loss of the r-determinant was found to be the result of a reciprocal recombination between the two IS/s flanking the r-determinant. This recombination depended upon both dor and recA gene functions.

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Selected References

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