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. 1962 Jul;48(7):1222–1230. doi: 10.1073/pnas.48.7.1222

THE ROLE OF DEOXYRIBONUCLEIC ACID IN RIBONUCLEIC ACID SYNTHESIS, III. THE INHIBITION OF THE ENZYMATIC SYNTHESIS OF RIBONUCLEIC ACID AND DEOXYRIBONUCLEIC ACID BY ACTINOMYCIN D AND PROFLAVIN*

Jerard Hurwitz 1,, J J Furth 1,, M Malamy 1,§, M Alexander 1
PMCID: PMC220936  PMID: 14450185

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Selected References

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  1. CHAMBERLIN M., BERG P. Deoxyribo ucleic acid-directed synthesis of ribonucleic acid by an enzyme from Escherichia coli. Proc Natl Acad Sci U S A. 1962 Jan 15;48:81–94. doi: 10.1073/pnas.48.1.81. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cohen S. S., Barner H. D. STUDIES ON UNBALANCED GROWTH IN ESCHERICHIA COLI. Proc Natl Acad Sci U S A. 1954 Oct;40(10):885–893. doi: 10.1073/pnas.40.10.885. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. DE MARS R. I., LURIA S. E., FISHER H., LEVINTHAL C. The production of incomplete bacteriophage particles by the action of proflavine and the properties of the incomplete particles. Ann Inst Pasteur (Paris) 1953 Jan;84(1):113–128. [PubMed] [Google Scholar]
  4. FURTH J. J., HURWITZ J., GOLDMANN M. The directing role of DNA in RNA synthesis. Specificity of the deoxyadenylate deoxythymidvlate copolymer as a primer. Biochem Biophys Res Commun. 1961 Apr 28;4:431–435. doi: 10.1016/0006-291x(61)90303-5. [DOI] [PubMed] [Google Scholar]
  5. FURTH J. J., HURWITZ J., KRUG R., ALEXANDER M. The incorporation of adenylic and cytidylic acids into ribonucleic acid. J Biol Chem. 1961 Dec;236:3317–3322. [PubMed] [Google Scholar]
  6. GOLDBERG I. H., RABINOWITZ M. Actionmycin D inhibition of deoxyribonucleic acid-dependent synthesis of ribonucleic acid. Science. 1962 Apr 27;136(3513):315–316. doi: 10.1126/science.136.3513.315. [DOI] [PubMed] [Google Scholar]
  7. GROS F., GILBERT W., HIATT H. H., ATTARDI G., SPAHR P. F., WATSON J. D. Molecular and biological characterization of messenger RNA. Cold Spring Harb Symp Quant Biol. 1961;26:111–132. doi: 10.1101/sqb.1961.026.01.016. [DOI] [PubMed] [Google Scholar]
  8. JACOB F., MONOD J. Genetic regulatory mechanisms in the synthesis of proteins. J Mol Biol. 1961 Jun;3:318–356. doi: 10.1016/s0022-2836(61)80072-7. [DOI] [PubMed] [Google Scholar]
  9. KATZ E., PUGH L. H., WAKSMAN S. A. Antibiotic and cytostatic properties of the actinomycins. J Bacteriol. 1956 Nov;72(5):660–665. doi: 10.1128/jb.72.5.660-665.1956. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. KIRK J. M. The mode of action of actinomycin D. Biochim Biophys Acta. 1960 Jul 29;42:167–169. doi: 10.1016/0006-3002(60)90769-1. [DOI] [PubMed] [Google Scholar]
  11. MAALØE O., SYMONDS N. Radioactive sulfur tracer studies on the reproduction of T4 bacteriophage. J Bacteriol. 1953 Feb;65(2):177–182. doi: 10.1128/jb.65.2.177-182.1953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. NAKATA A., SEKIGUCHI M., KAWAMATA J. Inhibition of multiplication of bacteriophage by actinomy cin. Nature. 1961 Jan 21;189:246–247. doi: 10.1038/189246b0. [DOI] [PubMed] [Google Scholar]
  13. ORGEL A., BRENNER S. Mutagenesis of bacteriophage T4 by acridines. J Mol Biol. 1961 Dec;3:762–768. doi: 10.1016/s0022-2836(61)80081-8. [DOI] [PubMed] [Google Scholar]
  14. PREISS J., DIECKMANN M., BERG P. The enzymic synthesis of amino acyl derivatives of ribonucleic acid. IV. The formation of the 3'-hydroxyl terminal trinucleotide sequence of amino acid-acceptor ribonucleic acid. J Biol Chem. 1961 Jun;236:1748–1757. [PubMed] [Google Scholar]
  15. RAUEN H. M., KERSTEN H., KERSTEN W. [On the mode of action of actinomycins]. Hoppe Seylers Z Physiol Chem. 1960 Dec 2;321:139–147. doi: 10.1515/bchm2.1960.321.1.139. [DOI] [PubMed] [Google Scholar]
  16. REICH E., FRANKLIN R. M., SHATKIN A. J., TATUM E. L. Effect of actinomycin D on cellular nucleic acid synthesis and virus production. Science. 1961 Aug 25;134(3478):556–557. doi: 10.1126/science.134.3478.556. [DOI] [PubMed] [Google Scholar]
  17. REICH E., SHATKIN A. J., TATUM E. L. Bacteriocidal action of mitomycin C. Biochim Biophys Acta. 1961 Oct 14;53:132–149. doi: 10.1016/0006-3002(61)90800-9. [DOI] [PubMed] [Google Scholar]
  18. Tissieres A., Schlessinger D., Gros F. AMINO ACID INCORPORATION INTO PROTEINS BY ESCHERICHIA COLI RIBOSOMES. Proc Natl Acad Sci U S A. 1960 Nov;46(11):1450–1463. doi: 10.1073/pnas.46.11.1450. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. VINING L. C., WAKSMAN S. A. Paper chromatographic identification of the actinomycins. Science. 1954 Sep 3;120(3114):389–390. doi: 10.1126/science.120.3114.389. [DOI] [PubMed] [Google Scholar]
  20. WOOD W. B., BERG P. The effect of enzymatically synthesized ribonucleic acid on amino acid incorporation by a soluble protein-ribosome system from Escherichia coli. Proc Natl Acad Sci U S A. 1962 Jan 15;48:94–104. doi: 10.1073/pnas.48.1.94. [DOI] [PMC free article] [PubMed] [Google Scholar]

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