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. 1983 Feb;153(2):861–866. doi: 10.1128/jb.153.2.861-866.1983

Regulation of hexitol catabolism in Streptococcus mutans.

S S Dills, S Seno
PMCID: PMC221706  PMID: 6401708

Abstract

Regulation of hexitol catabolism was investigated in Streptococcus mutans, a cariogenic human dental plaque bacterium. Induction of hexitol catabolic enzymes and phosphoenolpyruvate:hexitol phosphotransferase and hexitol phosphate dehydrogenase activities was regulated by an inducer exclusion mechanism initiated by D-glucose and 2-deoxy-D-glucose. Kinetic analysis of the inhibitory effect of 2-deoxy-D-glucose on initial hexitol uptake illustrated that this was a noncompetitive type of inhibition. In mutant strains of S. mutans lacking phosphoenolpyruvate:glucose phosphotransferase activity, 2-deoxy-D-glucose was unable to inhibit hexitol uptake. These observations provide evidence for possible molecular mechanisms for the exclusion process.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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