Skip to main content
NCBI home page
Molecular Medicine logoLink to Molecular Medicine
. 1998 Apr;4(4):205–213.

Cell cycle exit: growth arrest, apoptosis, and tumor suppression revisited.

L Philipson 1
PMCID: PMC2230366  PMID: 9606174

Full text

PDF
205

Images in this article

206Fig. 1
on p.206
207Fig. 2
on p.207
209Fig. 3
on p.209

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bird A. P. Gene number, noise reduction and biological complexity. Trends Genet. 1995 Mar;11(3):94–100. doi: 10.1016/S0168-9525(00)89009-5. [DOI] [PubMed] [Google Scholar]
  2. Borrow J., Stanton V. P., Jr, Andresen J. M., Becher R., Behm F. G., Chaganti R. S., Civin C. I., Disteche C., Dubé I., Frischauf A. M. The translocation t(8;16)(p11;p13) of acute myeloid leukaemia fuses a putative acetyltransferase to the CREB-binding protein. Nat Genet. 1996 Sep;14(1):33–41. doi: 10.1038/ng0996-33. [DOI] [PubMed] [Google Scholar]
  3. Cory S., Adams J. M. Transgenic mice and oncogenesis. Annu Rev Immunol. 1988;6:25–48. doi: 10.1146/annurev.iy.06.040188.000325. [DOI] [PubMed] [Google Scholar]
  4. Deng C., Zhang P., Harper J. W., Elledge S. J., Leder P. Mice lacking p21CIP1/WAF1 undergo normal development, but are defective in G1 checkpoint control. Cell. 1995 Aug 25;82(4):675–684. doi: 10.1016/0092-8674(95)90039-x. [DOI] [PubMed] [Google Scholar]
  5. Dulić V., Stein G. H., Far D. F., Reed S. I. Nuclear accumulation of p21Cip1 at the onset of mitosis: a role at the G2/M-phase transition. Mol Cell Biol. 1998 Jan;18(1):546–557. doi: 10.1128/mcb.18.1.546. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Eckner R., Ewen M. E., Newsome D., Gerdes M., DeCaprio J. A., Lawrence J. B., Livingston D. M. Molecular cloning and functional analysis of the adenovirus E1A-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes Dev. 1994 Apr 15;8(8):869–884. doi: 10.1101/gad.8.8.869. [DOI] [PubMed] [Google Scholar]
  7. Enari M., Sakahira H., Yokoyama H., Okawa K., Iwamatsu A., Nagata S. A caspase-activated DNase that degrades DNA during apoptosis, and its inhibitor ICAD. Nature. 1998 Jan 1;391(6662):43–50. doi: 10.1038/34112. [DOI] [PubMed] [Google Scholar]
  8. Garkavtsev I., Grigorian I. A., Ossovskaya V. S., Chernov M. V., Chumakov P. M., Gudkov A. V. The candidate tumour suppressor p33ING1 cooperates with p53 in cell growth control. Nature. 1998 Jan 15;391(6664):295–298. doi: 10.1038/34675. [DOI] [PubMed] [Google Scholar]
  9. Haber D. A. Splicing into senescence: the curious case of p16 and p19ARF. Cell. 1997 Nov 28;91(5):555–558. doi: 10.1016/s0092-8674(00)80441-9. [DOI] [PubMed] [Google Scholar]
  10. Hainaut P., Soussi T., Shomer B., Hollstein M., Greenblatt M., Hovig E., Harris C. C., Montesano R. Database of p53 gene somatic mutations in human tumors and cell lines: updated compilation and future prospects. Nucleic Acids Res. 1997 Jan 1;25(1):151–157. doi: 10.1093/nar/25.1.151. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hall M., Peters G. Genetic alterations of cyclins, cyclin-dependent kinases, and Cdk inhibitors in human cancer. Adv Cancer Res. 1996;68:67–108. doi: 10.1016/s0065-230x(08)60352-8. [DOI] [PubMed] [Google Scholar]
  12. Hao Z., Furunobu A., Nagata A., Okayama H. A zinc finger protein required for stationary phase viability in fission yeast. J Cell Sci. 1997 Oct;110(Pt 20):2557–2566. doi: 10.1242/jcs.110.20.2557. [DOI] [PubMed] [Google Scholar]
  13. Hengartner M. O. Programmed cell death in invertebrates. Curr Opin Genet Dev. 1996 Feb;6(1):34–38. doi: 10.1016/s0959-437x(96)90007-6. [DOI] [PubMed] [Google Scholar]
  14. Hurlin P. J., Quéva C., Eisenman R. N. Mnt, a novel Max-interacting protein is coexpressed with Myc in proliferating cells and mediates repression at Myc binding sites. Genes Dev. 1997 Jan 1;11(1):44–58. doi: 10.1101/gad.11.1.44. [DOI] [PubMed] [Google Scholar]
  15. Kamijo T., Zindy F., Roussel M. F., Quelle D. E., Downing J. R., Ashmun R. A., Grosveld G., Sherr C. J. Tumor suppression at the mouse INK4a locus mediated by the alternative reading frame product p19ARF. Cell. 1997 Nov 28;91(5):649–659. doi: 10.1016/s0092-8674(00)80452-3. [DOI] [PubMed] [Google Scholar]
  16. Kurokawa R., Kalafus D., Ogliastro M. H., Kioussi C., Xu L., Torchia J., Rosenfeld M. G., Glass C. K. Differential use of CREB binding protein-coactivator complexes. Science. 1998 Jan 30;279(5351):700–703. doi: 10.1126/science.279.5351.700. [DOI] [PubMed] [Google Scholar]
  17. Laherty C. D., Yang W. M., Sun J. M., Davie J. R., Seto E., Eisenman R. N. Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression. Cell. 1997 May 2;89(3):349–356. doi: 10.1016/s0092-8674(00)80215-9. [DOI] [PubMed] [Google Scholar]
  18. Lee J. S., Galvin K. M., See R. H., Eckner R., Livingston D., Moran E., Shi Y. Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300. Genes Dev. 1995 May 15;9(10):1188–1198. doi: 10.1101/gad.9.10.1188. [DOI] [PubMed] [Google Scholar]
  19. Lee T. C., Li L., Philipson L., Ziff E. B. Myc represses transcription of the growth arrest gene gas1. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12886–12891. doi: 10.1073/pnas.94.24.12886. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Levine A. J. p53, the cellular gatekeeper for growth and division. Cell. 1997 Feb 7;88(3):323–331. doi: 10.1016/s0092-8674(00)81871-1. [DOI] [PubMed] [Google Scholar]
  21. Loo S., Rine J. Silencing and heritable domains of gene expression. Annu Rev Cell Dev Biol. 1995;11:519–548. doi: 10.1146/annurev.cb.11.110195.002511. [DOI] [PubMed] [Google Scholar]
  22. Niculescu A. B., 3rd, Chen X., Smeets M., Hengst L., Prives C., Reed S. I. Effects of p21(Cip1/Waf1) at both the G1/S and the G2/M cell cycle transitions: pRb is a critical determinant in blocking DNA replication and in preventing endoreduplication. Mol Cell Biol. 1998 Jan;18(1):629–643. doi: 10.1128/mcb.18.1.629. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Peter M. E., Heufelder A. E., Hengartner M. O. Advances in apoptosis research. Proc Natl Acad Sci U S A. 1997 Nov 25;94(24):12736–12737. doi: 10.1073/pnas.94.24.12736. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Petrij F., Giles R. H., Dauwerse H. G., Saris J. J., Hennekam R. C., Masuno M., Tommerup N., van Ommen G. J., Goodman R. H., Peters D. J. Rubinstein-Taybi syndrome caused by mutations in the transcriptional co-activator CBP. Nature. 1995 Jul 27;376(6538):348–351. doi: 10.1038/376348a0. [DOI] [PubMed] [Google Scholar]
  25. Peverali F. A., Ramqvist T., Saffrich R., Pepperkok R., Barone M. V., Philipson L. Regulation of G1 progression by E2A and Id helix-loop-helix proteins. EMBO J. 1994 Sep 15;13(18):4291–4301. doi: 10.1002/j.1460-2075.1994.tb06749.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Reifsnyder C., Lowell J., Clarke A., Pillus L. Yeast SAS silencing genes and human genes associated with AML and HIV-1 Tat interactions are homologous with acetyltransferases. Nat Genet. 1996 Sep;14(1):42–49. doi: 10.1038/ng0996-42. [DOI] [PubMed] [Google Scholar]
  27. Rivard N., L'Allemain G., Bartek J., Pouysségur J. Abrogation of p27Kip1 by cDNA antisense suppresses quiescence (G0 state) in fibroblasts. J Biol Chem. 1996 Aug 2;271(31):18337–18341. doi: 10.1074/jbc.271.31.18337. [DOI] [PubMed] [Google Scholar]
  28. Rivier D. H., Rine J. Silencing: the establishment and inheritance of stable, repressed transcription states. Curr Opin Genet Dev. 1992 Apr;2(2):286–292. doi: 10.1016/s0959-437x(05)80286-2. [DOI] [PubMed] [Google Scholar]
  29. Rowan S., Ludwig R. L., Haupt Y., Bates S., Lu X., Oren M., Vousden K. H. Specific loss of apoptotic but not cell-cycle arrest function in a human tumor derived p53 mutant. EMBO J. 1996 Feb 15;15(4):827–838. [PMC free article] [PubMed] [Google Scholar]
  30. Ruaro E. M., Collavin L., Del Sal G., Haffner R., Oren M., Levine A. J., Schneider C. A proline-rich motif in p53 is required for transactivation-independent growth arrest as induced by Gas1. Proc Natl Acad Sci U S A. 1997 Apr 29;94(9):4675–4680. doi: 10.1073/pnas.94.9.4675. [DOI] [PMC free article] [PubMed] [Google Scholar]
  31. Serrano M., Lee H., Chin L., Cordon-Cardo C., Beach D., DePinho R. A. Role of the INK4a locus in tumor suppression and cell mortality. Cell. 1996 Apr 5;85(1):27–37. doi: 10.1016/s0092-8674(00)81079-x. [DOI] [PubMed] [Google Scholar]
  32. Shugart E. C., Umek R. M. Dexamethasone signaling is required to establish the postmitotic state of adipocyte development. Cell Growth Differ. 1997 Oct;8(10):1091–1098. [PubMed] [Google Scholar]
  33. Walsh K., Perlman H. Cell cycle exit upon myogenic differentiation. Curr Opin Genet Dev. 1997 Oct;7(5):597–602. doi: 10.1016/s0959-437x(97)80005-6. [DOI] [PubMed] [Google Scholar]
  34. Wechsler-Reya R. J., Elliott K. J., Prendergast G. C. A role for the putative tumor suppressor Bin1 in muscle cell differentiation. Mol Cell Biol. 1998 Jan;18(1):566–575. doi: 10.1128/mcb.18.1.566. [DOI] [PMC free article] [PubMed] [Google Scholar]
  35. Yang X. J., Ogryzko V. V., Nishikawa J., Howard B. H., Nakatani Y. A p300/CBP-associated factor that competes with the adenoviral oncoprotein E1A. Nature. 1996 Jul 25;382(6589):319–324. doi: 10.1038/382319a0. [DOI] [PubMed] [Google Scholar]

Articles from Molecular Medicine are provided here courtesy of The Feinstein Institute for Medical Research at North Shore LIJ

RESOURCES