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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Oct;64(2):451–458. doi: 10.1073/pnas.64.2.451

INTERBASE VIBRATIONAL COUPLING IN G:C POLYNUCLEOTIDE HELICES

F B Howard 1,2, J Frazier 1,2, H Todd Miles 1,2
PMCID: PMC223363  PMID: 5261027

Abstract

The carbonyl stretching vibrations of G and C residues undergo frequency changes when a helical complex is formed from nonordered G and C components. We have prepared a series of two-stranded G:C helices having chemical and isotopic (18O) substitutions which lead to variation of the observed vibrational frequencies. Infrared spectra of these helices clearly demonstrate that vibrational coupling occurs between the guanine and cytosine residues in the helix. As a result of this coupling through the hydrogen bonds, the two carbonyl bands undergo frequency shifts of equal magnitude and opposite sign, with mixing of G and C character in the observed interacted vibrations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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