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. 1969 Aug;63(4):1128–1135. doi: 10.1073/pnas.63.4.1128

A NONDEFECTIVE (COMPETENT) ADENOVIRUS-SV40 HYBRID ISOLATED FROM THE AD.2-SV40 HYBRID POPULATION

Andrew M Lewis Jr 1,*, Myron J Levin 1,†, William H Wiese 1,*, Clyde S Crumpacker 1,*, Patrick H Henry 1,†
PMCID: PMC223439  PMID: 4311250

Abstract

A new nondefective hybrid virus has been plaque-isolated from the Ad.2-SV40 hybrid population. This virus replicates efficiently with one-hit kinetics in both human embryonic kidney and African green monkey kidney cells, induces an SV40 specific antigen which is detectable by immunofluorescence and complement-fixation using sera from SV40 tumor-bearing hamsters, and produces SV40-specific RNA detectable by DNA-RNA hybridization. The SV40-specific antigen induced by this virus is heat-stable, sensitive to inhibitors of DNA synthesis, serologically different from SV40 T and viral antigens, and is an unrecognized SV40 antigen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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