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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Jul;63(3):753–758. doi: 10.1073/pnas.63.3.753

MIXED CULTURE CYTOPATHOGENICITY: A NEW TEST FOR GROWTH OF MURINE LEUKEMIA VIRUSES IN TISSUE CULTURE

Vaclav Klement 1,*, Wallace P Rowe 1, Janet W Hartley 1, Wendell E Pugh 1
PMCID: PMC223516  PMID: 4186808

Abstract

Tissue culture cells of a Rous virus-induced rat tumor undergo syncytium formation when placed in contact with mouse embryo cell cultures infected with murine leukemia viruses. This phenomenon can be used as a cytopathic end point for isolating and titrating these viruses in tissue culture. The principle should be applicable to detection of leukemia viruses of other species.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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