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. 1969 Mar;62(3):704–707. doi: 10.1073/pnas.62.3.704

SELECTIVE DESTRUCTION OF ADRENAL CORTEX BY PULSE DOSES OF DERIVATIVES OF 12-METHYLBENZ(a)ANTHRACENE*

Charles Huggins 1, Sotokichi Morii 1,†, John Pataki 1
PMCID: PMC223655  PMID: 5256999

Abstract

Pulse doses of emulsions of ten polynuclear aromatic hydrocarbons were found to destroy the adrenal cortex selectively.

The corticolytic hydrocarbons are derivatives of 12-methylbenz(a)anthracene which possess at position 7 an alkyl, methoxymethyl, formyl, or hydroxyalkyl group. It would appear that the active corticolytic agent is 7-hydroxyalkyl-12-methylbenz(a)anthracene, of chemical source or generated in metabolism.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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