Skip to main content
PMC home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1969 Mar;62(3):741–748. doi: 10.1073/pnas.62.3.741

RELEASE OF NEWLY SYNTHESIZED DOPAMINE FROM DOPAMINE-CONTAINING TERMINALS IN THE STRIATUM OF THE RAT*

M J Besson 1, A Cheramy 1, P Feltz 1,†, J Glowinski 1
PMCID: PMC223661  PMID: 4389748

Abstract

The extraneuronal spontaneous efflux of 3H-dopamine synthesized endogenously in dopamine terminals has been demonstrated in vitro, by collecting the 3H amine in superfusates of isolated striatum of the rat previously incubated with 3H-tyrosine. The 3H-dopamine newly synthesized appears to be preferentially released. Furthermore, amphetamine and a monoamine oxidase inhibitor (Carton) markedly increased the release of 3H-dopamine. This effect was also observed with substances normally contained in some striatal neurons: acetylcholine and 5-hydroxytryptamine.

Full text

PDF
742

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BAIRD J. R., LEWIS J. J. THE EFFECTS OF COCAINE, AMPHETAMINE AND SOME AMPHETAMINE-LIKE COMPOUNDS ON THE IN VIVO LEVELS OF NORADRENALINE AND DOPAMINE IN THE RAT BRAIN. Biochem Pharmacol. 1964 Nov;13:1475–1482. doi: 10.1016/0006-2952(64)90197-2. [DOI] [PubMed] [Google Scholar]
  2. Baldessarini R. J., Kopin I. J. Tritiated norepinephrine: release from brain slices by electrical stimulation. Science. 1966 Jun 17;152(3729):1630–1631. doi: 10.1126/science.152.3729.1630. [DOI] [PubMed] [Google Scholar]
  3. Corrodi H., Fuxe K., Hammer W., Sjöqvist F., Ungerstedt U. Oxotremorine and central monoamine neurons. Life Sci. 1967 Dec 1;6(23):2557–2566. doi: 10.1016/0024-3205(67)90321-9. [DOI] [PubMed] [Google Scholar]
  4. Fuxe K., Ungerstedt U. Histochemical studies on the effect of (positive)-amphetamine, drugs of the imipramine group and tryptamine on central catecholamine and 5-hydroxytryptamine neurons after intraventricular injection of catecholamines and 5-hydroxytryptamine. Eur J Pharmacol. 1968 Sep;4(2):135–144. doi: 10.1016/0014-2999(68)90169-6. [DOI] [PubMed] [Google Scholar]
  5. GLOWINSKI J., KOPIN I. J., AXELROD J. METABOLISM OF (H3)NOREPINEPHRINE IN THE RAT BRAIN. J Neurochem. 1965 Jan;12:25–30. doi: 10.1111/j.1471-4159.1965.tb10247.x. [DOI] [PubMed] [Google Scholar]
  6. Glowinski J., Axelrod J., Iversen L. L. Regional studies of catecholamines in the rat brain. IV. Effects of drugs on the disposition and metabolism of H3-norepinephrine and H3-dopamine. J Pharmacol Exp Ther. 1966 Jul;153(1):30–41. [PubMed] [Google Scholar]
  7. Glowinski J., Baldessarini R. J. Metabolism of norepinephrine in the central nervous system. Pharmacol Rev. 1966 Dec;18(4):1201–1238. [PubMed] [Google Scholar]
  8. Hornykiewicz O. Dopamine (3-hydroxytyramine) and brain function. Pharmacol Rev. 1966 Jun;18(2):925–964. [PubMed] [Google Scholar]
  9. Iversen L. L., Glowinski J. Regional studies of catecholamines in the rat brain. II. Rate of turnover of catecholamines in various brain regions. J Neurochem. 1966 Aug;13(8):671–682. doi: 10.1111/j.1471-4159.1966.tb09874.x. [DOI] [PubMed] [Google Scholar]
  10. Kopin I. J., Breese G. R., Krauss K. R., Weise V. K. Selective release of newly synthesized norepinephrine from the cat spleen during sympathetic nerve stimulation. J Pharmacol Exp Ther. 1968 Jun;161(2):271–278. [PubMed] [Google Scholar]
  11. LAVERTY R., SHARMAN D. F. THE ESTIMATION OF SMALL QUANTITIES OF 3,4-DIHYDROXYPHENYLETHYLAMINE IN TISSUES. Br J Pharmacol Chemother. 1965 Apr;24:538–548. doi: 10.1111/j.1476-5381.1965.tb01744.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Lindmar R., Löffelholz K., Muscholl E. A muscarinic mechanism inhibiting the release of noradrenaline from peripheral adrenergic nerve fibres by nicotinic agents. Br J Pharmacol Chemother. 1968 Feb;32(2):280–294. doi: 10.1111/j.1476-5381.1968.tb00972.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. MCLENNAN H. THE RELEASE OF ACETYLCHOLINE AND OF 3-HYDROXYTYRAMINE FROM THE CAUDATE NUCLEUS. J Physiol. 1964 Oct;174:152–156. doi: 10.1113/jphysiol.1964.sp007478. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. McKenzie G. M., Szerb J. C. The effect of dihydroxyphenylalanine, pheniprazine and dextroamphetamine on the in vivo release of dopamine from the caudate nucleus. J Pharmacol Exp Ther. 1968 Aug;162(2):302–308. [PubMed] [Google Scholar]
  15. Portig P. J., Sharman D. F., Vogt M. Release by tubocurarine of dopamine and homovanillic acid from the superfused caudate nucleus. J Physiol. 1968 Feb;194(2):565–572. doi: 10.1113/jphysiol.1968.sp008425. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Sedvall G. C., Weise V. K., Kopin I. J. The rate of norepinephrine synthesis measured in vivo during short intervals; influence of adrenergic nerve impulse activity. J Pharmacol Exp Ther. 1968 Feb;159(2):274–282. [PubMed] [Google Scholar]
  17. Thierry A. M., Javoy F., Glowinski J., Kety S. S. Effects of stress on the metabolism of norepinephrine, dopamine and serotonin in the central nervous system of the rat. I. Modifications of norepinephrine turnover. J Pharmacol Exp Ther. 1968 Sep;163(1):163–171. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES