Abstract
We present a general model for data integration systems using a mediated schema to represent commonalities in the underlying sources. These sources are mapped to the mediated schema using source descriptions. Users can pose queries against the mediated schema, allowing the system to generate automatically a query plan that enumerates and ranks all possible ways in which the query could be answered. We apply this approach to the domain of online genetic databases, demonstrating the system s ability to answer relevant queries across multiple sources.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Butler D. Genomics. Are you ready for the revolution? Nature. 2001 Feb 15;409(6822):758–760. doi: 10.1038/35057400. [DOI] [PubMed] [Google Scholar]
- Etzold T., Ulyanov A., Argos P. SRS: information retrieval system for molecular biology data banks. Methods Enzymol. 1996;266:114–128. doi: 10.1016/s0076-6879(96)66010-8. [DOI] [PubMed] [Google Scholar]
- Ideker T., Thorsson V., Ranish J. A., Christmas R., Buhler J., Eng J. K., Bumgarner R., Goodlett D. R., Aebersold R., Hood L. Integrated genomic and proteomic analyses of a systematically perturbed metabolic network. Science. 2001 May 4;292(5518):929–934. doi: 10.1126/science.292.5518.929. [DOI] [PubMed] [Google Scholar]
- Lander E. S., Linton L. M., Birren B., Nusbaum C., Zody M. C., Baldwin J., Devon K., Dewar K., Doyle M., FitzHugh W. Initial sequencing and analysis of the human genome. Nature. 2001 Feb 15;409(6822):860–921. doi: 10.1038/35057062. [DOI] [PubMed] [Google Scholar]
- National Prevention Information Network, Centers for Disease Control and Prevention Reports from the Eighth Annual Conference on Retroviruses and Opportunistic Infections. Chicago, February 4-8, 2001. Body Posit. 2001 Apr;14(4):11–16. [PubMed] [Google Scholar]
- Ouellette F. Internet resources for the clinical geneticist. Clin Genet. 1999 Sep;56(3):179–185. doi: 10.1034/j.1399-0004.1999.560301.x. [DOI] [PubMed] [Google Scholar]
- Roos D. S. Computational biology. Bioinformatics--trying to swim in a sea of data. Science. 2001 Feb 16;291(5507):1260–1261. doi: 10.1126/science.291.5507.1260. [DOI] [PubMed] [Google Scholar]
- Rosse C., Mejino J. L., Modayur B. R., Jakobovits R., Hinshaw K. P., Brinkley J. F. Motivation and organizational principles for anatomical knowledge representation: the digital anatomist symbolic knowledge base. J Am Med Inform Assoc. 1998 Jan-Feb;5(1):17–40. doi: 10.1136/jamia.1998.0050017. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Schuler G. D., Epstein J. A., Ohkawa H., Kans J. A. Entrez: molecular biology database and retrieval system. Methods Enzymol. 1996;266:141–162. doi: 10.1016/s0076-6879(96)66012-1. [DOI] [PubMed] [Google Scholar]
- Tarczy-Hornoch P., Covington M. L., Edwards J., Shannon P., Fuller S., Pagon R. A. Creation and maintenance of Helix, a Web based database of medical genetics laboratories, to serve the needs of the genetics community. Proc AMIA Symp. 1998:341–345. [PMC free article] [PubMed] [Google Scholar]
- Venter J. C., Adams M. D., Myers E. W., Li P. W., Mural R. J., Sutton G. G., Smith H. O., Yandell M., Evans C. A., Holt R. A. The sequence of the human genome. Science. 2001 Feb 16;291(5507):1304–1351. doi: 10.1126/science.1058040. [DOI] [PubMed] [Google Scholar]
- Wheeler D. L., Church D. M., Lash A. E., Leipe D. D., Madden T. L., Pontius J. U., Schuler G. D., Schriml L. M., Tatusova T. A., Wagner L. Database resources of the National Center for Biotechnology Information. Nucleic Acids Res. 2001 Jan 1;29(1):11–16. doi: 10.1093/nar/29.1.11. [DOI] [PMC free article] [PubMed] [Google Scholar]