Abstract
Intracardiac injection, in hooded Lister rats, of syngeneic MC28 sarcoma cells never induced tumour growth in normal bowel. Tumour growth occurred at the site of a colonic anastomosis if surgery preceded tumour injection but not if it followed tumour injection, even by as little as 1 h. Maximum enhancement of tumour growth occurred when the healing process had progressed between 2 and 8 days, with a peak at 5 to 7 days. The enhancing effect was largely over by the time the healing had progressed 14 days. The syngeneic OES5 breast carcinoma also grew at colonic anastomoses when surgery preceded tumour injection by 5 days, but not in normal colon. The MC28 sarcoma also grew at ileal anastomoses but not in the normal ileum after intracardiac injection. By injecting radiolabelled sarcoma cells, an estimate of the probability of a single bloodborne tumour cell lodging at a colonic anastomosis and leading to a tumour deposit was calculated to be of the order of 1:43 whereas the probability of the cell lodging in normal colon and causing a deposit is less than 1:4 x 10(4).
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ALEXANDER J. W., ALTEMEIER W. A. SUSCEPTIBILITY OF INJURED TISSUES TO HEMATOGENOUS METASTASES: AN EXPERIMENTAL STUDY. Ann Surg. 1964 Jun;159:933–944. doi: 10.1097/00000658-196406000-00010. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cohn I., Jr Implantation in cancer of the colon. Surg Gynecol Obstet. 1967 Mar;124(3):501–508. [PubMed] [Google Scholar]
- FISHER E. R., FISHER B. EXPERIMENTAL STUDY OF FACTORS INFLUENCING DEVELOPMENT OF HEPATIC METASTASES FROM CIRCULATING TUMOR CELLS. Acta Cytol. 1965 Mar-Apr;9:146–159. [PubMed] [Google Scholar]
- Fisher B., Fisher E. R., Feduska N. Trauma and the localization of tumor cells. Cancer. 1967 Jan;20(1):23–30. doi: 10.1002/1097-0142(1967)20:1<23::aid-cncr2820200103>3.0.co;2-p. [DOI] [PubMed] [Google Scholar]
- Murphy P., Alexander P., Kirkham N., Fleming J., Taylor I. Pattern of spread of bloodborne tumour. Br J Surg. 1986 Oct;73(10):829–834. doi: 10.1002/bjs.1800731024. [DOI] [PubMed] [Google Scholar]
- Murphy P., Alexander P., Senior P. V., Fleming J., Kirkham N., Taylor I. Mechanisms of organ selective tumour growth by bloodborne cancer cells. Br J Cancer. 1988 Jan;57(1):19–31. doi: 10.1038/bjc.1988.3. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ROBINSON K. P., HOPPE E. The development of blood-borne metastases. Effect of local trauma and ischemia. Arch Surg. 1962 Nov;85:720–724. doi: 10.1001/archsurg.1962.01310050022005. [DOI] [PubMed] [Google Scholar]
- Skipper D., Cooper A. J., Marston J. E., Taylor I. Exfoliated cells and in vitro growth in colorectal cancer. Br J Surg. 1987 Nov;74(11):1049–1052. doi: 10.1002/bjs.1800741130. [DOI] [PubMed] [Google Scholar]
- TENNANT J. R. EVALUATION OF THE TRYPAN BLUE TECHNIQUE FOR DETERMINATION OF CELL VIABILITY. Transplantation. 1964 Nov;2:685–694. doi: 10.1097/00007890-196411000-00001. [DOI] [PubMed] [Google Scholar]
- Umpleby H. C., Fermor B., Symes M. O., Williamson R. C. Viability of exfoliated colorectal carcinoma cells. Br J Surg. 1984 Sep;71(9):659–663. doi: 10.1002/bjs.1800710902. [DOI] [PubMed] [Google Scholar]