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. 1988 Jan;57(1):70–73. doi: 10.1038/bjc.1988.11

Antitumour effects of streptococcal lipoteichoic acids on Meth A fibrosarcoma.

H Usami 1, A Yamamoto 1, W Yamashita 1, Y Sugawara 1, S Hamada 1, T Yamamoto 1, K Kato 1, S Kokeguchi 1, H Ohokuni 1, S Kotani 1
PMCID: PMC2246679  PMID: 3279996

Abstract

The antitumour effects of lipoteichoic acids (LTA) extracted from Streptococcus pyogenes were studied in comparison with other streptococcal cellular components. LTA suppressed the tumour growth of both solid- and ascites-type Meth A fibrosarcoma as did the whole cells of S. pyogenes (OK-432). No other cellular components, such as cell wall peptidoglycan, group-specific C-carbohydrate or type-specific M protein, suppressed the growth of Meth A. LTA, but not the other cellular components, induced tumour necrosis factor (TNF) in Propionibacterium acnes-primed mice. LTA had no direct killing effects on Meth A cells. These results indicate that LTA may be an important antitumour component of OK-432 and that one of the antitumour mechanisms by this streptococcal preparation is the induction of TNF.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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