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. 1988 Aug;58(2):144–146. doi: 10.1038/bjc.1988.181

Response of chemically induced primary colon tumours of the mouse to flavone acetic acid (NSC 347 512).

G Pratesi 1, C Manzotti 1, G Damia 1, M D'Incalci 1
PMCID: PMC2246749  PMID: 3166904

Abstract

Flavone acetic acid (FAA) is a compound with proven activity against various transplantable colon cancers in mice. In this study it was evaluated against primary colon tumours, chemically induced by methylazoxymethanol in outbred CF1 mice. FAA was given i.v. at doses of 70 or 100 or 150 mg kg-1 every 7 days for 6 weeks. Only 4 out of 60 FAA treated mice died of toxicity. FAA reduced tumour number and tumour burden compared to control mice (P less than 0.05 at least), with no apparent dose-response relationship. Antitumour activity of FAA was comparable to that of 5-fluorouracil (5-FU) used as standard. Moreover, FAA was more effective that 5-FU against large tumours. FAA levels in plasma and different tissues (including colonic neoplastic lesions) after a single i.v. dose of 150 mg kg-1 were investigated. Tumour FAA levels appear insufficient to be responsible for the antitumour activity based only on a direct FAA cytotoxic effect. The results confirm clinical interest in FAA and suggest that mechanisms other than direct cytotoxicity may be involved in its activity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bibby M. C., Double J. A., Phillips R. M., Loadman P. M. Factors involved in the anti-cancer activity of the investigational agents LM985 (flavone acetic acid ester) and LM975 (flavone acetic acid). Br J Cancer. 1987 Feb;55(2):159–163. doi: 10.1038/bjc.1987.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Capolongo L. S., Balconi G., Ubezio P., Giavazzi R., Taraboletti G., Regonesi A., Yoder O. C., D'Incalci M. Antiproliferative properties of flavone acetic acid (NSC 347512) (LM 975), a new anticancer agent. Eur J Cancer Clin Oncol. 1987 Oct;23(10):1529–1535. doi: 10.1016/0277-5379(87)90096-4. [DOI] [PubMed] [Google Scholar]
  3. Ching L. M., Baguley B. C. Induction of natural killer cell activity by the antitumour compound flavone acetic acid (NSC 347 512). Eur J Cancer Clin Oncol. 1987 Jul;23(7):1047–1050. doi: 10.1016/0277-5379(87)90357-9. [DOI] [PubMed] [Google Scholar]
  4. Corbett T. H., Bissery M. C., Wozniak A., Plowman J., Polin L., Tapazoglou E., Dieckman J., Valeriote F. Activity of flavone acetic acid (NSC-347512) against solid tumors of mice. Invest New Drugs. 1986;4(3):207–220. doi: 10.1007/BF00179586. [DOI] [PubMed] [Google Scholar]
  5. Giavazzi R., Garofalo A., Damia G., Garattini S., D'Incalci M. Response to flavone acetic acid (NSC 347512) of primary and metastatic human colorectal carcinoma xenografts. Br J Cancer. 1988 Mar;57(3):277–280. doi: 10.1038/bjc.1988.59. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Manda T., Shimomura K., Mukumoto S., Kobayashi K., Mizota T., Hirai O., Matsumoto S., Oku T., Nishigaki F., Mori J. Recombinant human tumor necrosis factor-alpha: evidence of an indirect mode of antitumor activity. Cancer Res. 1987 Jul 15;47(14):3707–3711. [PubMed] [Google Scholar]
  7. Plowman J., Narayanan V. L., Dykes D., Szarvasi E., Briet P., Yoder O. C., Paull K. D. Flavone acetic acid: a novel agent with preclinical antitumor activity against colon adenocarcinoma 38 in mice. Cancer Treat Rep. 1986 May;70(5):631–635. [PubMed] [Google Scholar]
  8. Pratesi G., Deschner E. E. The antitumoral activity of 4'-deoxydoxorubicin compared to doxorubicin and 5-fluorouracil on methylazoxymethanol acetate-induced colon tumors in CF1 mice. Cancer. 1984 Jul 1;54(1):18–24. doi: 10.1002/1097-0142(19840701)54:1<18::aid-cncr2820540105>3.0.co;2-y. [DOI] [PubMed] [Google Scholar]
  9. Pratesi G., Gianni L., Manzotti C., Zunino F. Sequence dependence of the antitumor and toxic effects of 5-fluorouracil and cis-diamminedichloroplatinum combination on primary colon tumors in mice. Cancer Chemother Pharmacol. 1988;21(3):237–240. doi: 10.1007/BF00262777. [DOI] [PubMed] [Google Scholar]
  10. Smith G. P., Calveley S. B., Smith M. J., Baguley B. C. Flavone acetic acid (NSC 347512) induces haemorrhagic necrosis of mouse colon 26 and 38 tumours. Eur J Cancer Clin Oncol. 1987 Aug;23(8):1209–1211. doi: 10.1016/0277-5379(87)90157-x. [DOI] [PubMed] [Google Scholar]
  11. Tagliabue A., Luini W., Soldateschi D., Boraschi D. Natural killer activity of gut mucosal lymphoid cells in mice. Eur J Immunol. 1981 Nov;11(11):919–922. doi: 10.1002/eji.1830111112. [DOI] [PubMed] [Google Scholar]

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