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. 1988 Dec;58(6):738–741. doi: 10.1038/bjc.1988.300

Chemotherapy-radiation interactions in human cervix carcinoma xenografts.

K S Tonkin 1, L R Kelland 1, G G Steel 1
PMCID: PMC2246868  PMID: 2465016

Abstract

The combination of irradiation and four agents of clinical interest in the treatment of cervix carcinoma (bleomycin, etoposide, cisplatin and ifosfamide) have been investigated using two human cervix carcinoma xenografts in nude mice. As a model of clinical brachytherapy regimes, radiation was administered at a continuous low dose rate of 5 cGy min-1 to a total dose of 9 or 12 Gy. No substantial enhancement in tumour growth delay over that observed for radiation alone was observed with bleomycin, etoposide or cisplatin. Ifosfamide, however, led to substantial additional growth delay, an effect which was lost when irradiation was administered at a higher dose rate of 70 cGy min-1. As dose-rates of around 5 cGy min-1 allow greater repair of radiation damage than at the higher dose-rate without significant cell cycling or repopulation, it is possible that ifosfamide may act as an inhibitor of repair processes in this model. It would be of interest to evaluate the role of ifosfamide and brachytherapy regimes in the clinical treatment of carcinoma of the cervix.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barrett A., Depledge M. H., Powles R. L. Interstitial pneumonitis following bone marrow transplantation after low dose rate total body irradiation. Int J Radiat Oncol Biol Phys. 1983 Jul;9(7):1029–1033. doi: 10.1016/0360-3016(83)90393-0. [DOI] [PubMed] [Google Scholar]
  2. Blake P. R., Branson A. N., Lambert H. E. Combined radiotherapy and chemotherapy for advanced carcinoma of the cervix. Clin Radiol. 1986 Sep;37(5):465–469. doi: 10.1016/s0009-9260(86)80055-1. [DOI] [PubMed] [Google Scholar]
  3. Cohen C. J., Deppe G., Castro-Marin C. A., Bruckner H. W. Treatment of advanced squamous cell carcinoma of the cervix with cis-platinum (II) diamminedichloride (NSC-119875). Am J Obstet Gynecol. 1978 Apr 1;130(7):853–854. doi: 10.1016/0002-9378(78)90023-6. [DOI] [PubMed] [Google Scholar]
  4. Cummings B., Keane T., Thomas G., Harwood A., Rider W. Results and toxicity of the treatment of anal canal carcinoma by radiation therapy or radiation therapy and chemotherapy. Cancer. 1984 Nov 15;54(10):2062–2068. doi: 10.1002/1097-0142(19841115)54:10<2062::aid-cncr2820541004>3.0.co;2-t. [DOI] [PubMed] [Google Scholar]
  5. Elkind M. M. Fundamental questions in the combined use of radiation and chemicals in the treatment of cancer. Int J Radiat Oncol Biol Phys. 1979 Sep;5(9):1711–1720. doi: 10.1016/0360-3016(79)90803-4. [DOI] [PubMed] [Google Scholar]
  6. Kelland L. R., Burgess L., Steel G. G. Characterization of four new cell lines derived from human squamous carcinomas of the uterine cervix. Cancer Res. 1987 Sep 15;47(18):4947–4952. [PubMed] [Google Scholar]
  7. Lockhart S. P., Down J. D., Steel G. G. The effect of low dose-rate and cyclophosphamide on the radiation tolerance of the mouse lung. Int J Radiat Oncol Biol Phys. 1986 Aug;12(8):1437–1440. doi: 10.1016/0360-3016(86)90189-6. [DOI] [PubMed] [Google Scholar]
  8. Meeker W. R., Jr, Sickle-Santanello B. J., Philpott G., Kenady D., Bland K. I., Hill G. H., Popp M. B. Combined chemotherapy, radiation, and surgery for epithelial cancer of the anal canal. Cancer. 1986 Feb 1;57(3):525–529. doi: 10.1002/1097-0142(19860201)57:3<525::aid-cncr2820570320>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  9. Steel G. G., Down J. D., Peacock J. H., Stephens T. C. Dose-rate effects and the repair of radiation damage. Radiother Oncol. 1986 Apr;5(4):321–331. doi: 10.1016/s0167-8140(86)80181-5. [DOI] [PubMed] [Google Scholar]
  10. Steel G. G. Terminology in the description of drug-radiation interactions. Int J Radiat Oncol Biol Phys. 1979 Aug;5(8):1145–1150. doi: 10.1016/0360-3016(79)90634-5. [DOI] [PubMed] [Google Scholar]
  11. Tannock I. F., Browman G. Lack of evidence for a role of chemotherapy in the routine management of locally advanced head and neck cancer. J Clin Oncol. 1986 Jul;4(7):1121–1126. doi: 10.1200/JCO.1986.4.7.1121. [DOI] [PubMed] [Google Scholar]
  12. Tannock I. F. Chemotherapy for head and neck cancer. J Otolaryngol. 1984 Apr;13(2):99–104. [PubMed] [Google Scholar]
  13. Thigpen T., Shingleton H., Homesley H., LaGasse L., Blessing J. cis-Dichlorodiammineplatinum(II) in the treatment of gynecologic malignancies: phase II trials by the Gynecologic Oncology Group. Cancer Treat Rep. 1979 Sep-Oct;63(9-10):1549–1555. [PubMed] [Google Scholar]
  14. Ward B. G., Shepherd J. H., Monaghan J. M. Occult advanced cervical cancer. Br Med J (Clin Res Ed) 1985 May 4;290(6478):1301–1302. doi: 10.1136/bmj.290.6478.1301. [DOI] [PMC free article] [PubMed] [Google Scholar]

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