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. 1989 Apr;59(4):622–626. doi: 10.1038/bjc.1989.126

Genetic and immunopathological findings in a lymphoma family.

H T Lynch 1, J N Marcus 1, D D Weisenburger 1, P Watson 1, M L Fitzsimmons 1, H Grierson 1, D M Smith 1, J Lynch 1, D Purtilo 1
PMCID: PMC2247145  PMID: 2713249

Abstract

We have studied a remarkable family with seven cases of malignant lymphoma extending through three generations wherein five sisters and their mother had histopathologically documented non-Hodgkin's lymphoma, while a granddaughter had Hodgkin's disease. An immunological study of three lymphoma survivors, nine of their first degree relatives, and four spouse controls was undertaken. Significant findings consisted of a depressed serum IgG3 level in four of the nine first-degree relatives; in two of these four, lymphocyte stimulation by both pokeweed mitogen and concanavalin A were significantly depressed. The subtle immunological abnormalities present in this kindred may be associated with the pathogenesis of the lymphomas.

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Selected References

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