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. 1987 Oct;99(2):485–499. doi: 10.1017/s0950268800067996

An assessment of methods for routine local monitoring of vaccine efficacy, with particular reference to measles and pertussis.

J A Clarkson 1, P E Fine 1
PMCID: PMC2249298  PMID: 3678405

Abstract

The efficacy of measles and pertussis vaccines was investigated using several different procedures based upon data routinely available at Local Health Authority level in England and Wales. It is demonstrated that such estimates can be derived by methods which can be carried out simply and routinely by local health department staff. Several theoretical and practical difficulties in the procedures are discussed. It is recommended that Health Authorities consider monitoring by a routine procedure based on crude case-control analysis of recorded vaccination status of notified cases compared with that of the population in the Child Health computer file, or of matched controls drawn from Child Health Registers. A simple protocol for such studies is provided.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker M. R., Bandaranayake R., Schweiger M. S. Differences in rate of uptake of immunisation among ethnic groups. Br Med J (Clin Res Ed) 1984 Apr 7;288(6423):1075–1078. doi: 10.1136/bmj.288.6423.1075. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Clarkson J. A., Fine P. E. Delays in notification of infectious disease. Health Trends. 1987 Feb;19(1):9–11. [PubMed] [Google Scholar]
  3. Clarkson J. A., Fine P. E. The efficiency of measles and pertussis notification in England and Wales. Int J Epidemiol. 1985 Mar;14(1):153–168. doi: 10.1093/ije/14.1.153. [DOI] [PubMed] [Google Scholar]
  4. Fleiss J. L. The Mantel-Haenszel estimator in case-control studies with varying numbers of controls matched to each case. Am J Epidemiol. 1984 Jul;120(1):1–3. doi: 10.1093/oxfordjournals.aje.a113858. [DOI] [PubMed] [Google Scholar]
  5. MANTEL N., HAENSZEL W. Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst. 1959 Apr;22(4):719–748. [PubMed] [Google Scholar]
  6. Macgregor J. D., MacDonald J., Ingram E. A., McDonnell M., Marshall B. Epidemic measles in Shetland during 1977 and 1978. Br Med J (Clin Res Ed) 1981 Feb 7;282(6262):434–436. doi: 10.1136/bmj.282.6262.434. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Marks J. S., Halpin T. J., Orenstein W. A. Measles vaccine efficacy in children previously vaccinated at 12 months of age. Pediatrics. 1978 Dec;62(6):955–960. [PubMed] [Google Scholar]
  8. Orenstein W. A., Bernier R. H., Dondero T. J., Hinman A. R., Marks J. S., Bart K. J., Sirotkin B. Field evaluation of vaccine efficacy. Bull World Health Organ. 1985;63(6):1055–1068. [PMC free article] [PubMed] [Google Scholar]
  9. Smith P. G., Rodrigues L. C., Fine P. E. Assessment of the protective efficacy of vaccines against common diseases using case-control and cohort studies. Int J Epidemiol. 1984 Mar;13(1):87–93. doi: 10.1093/ije/13.1.87. [DOI] [PubMed] [Google Scholar]
  10. Williams W. O., Dajda R. Validation of sources of pertussis immunisation data. J Epidemiol Community Health. 1980 Dec;34(4):309–311. doi: 10.1136/jech.34.4.309. [DOI] [PMC free article] [PubMed] [Google Scholar]

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