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. 1988 Aug;101(1):21–42. doi: 10.1017/s0950268800029198

Carriage of Neisseria meningitidis: investigations in a military establishment.

J V Pether 1, N F Lightfoot 1, R J Scott 1, J Morgan 1, A P Steele-Perkins 1, S C Sheard 1
PMCID: PMC2249339  PMID: 3042437

Abstract

A prevalence study of personnel on a Royal Naval Air Station revealed that 23.0% of 2479 personnel were carrying a meningococcus. Selected groups of personnel were subsequently swabbed monthly for a year. We have shown that it is only by repeated swabbing and the use of optimal methods including enrichment media that one can have a hope of identifying the 'true' carriage rate. A presumed virulent strain of Neisseria meningitidis B15 P1.16 was repeatedly isolated from three personnel who remained well, as did their colleagues both at their work place and socially. The study served to emphasize our lack of knowledge of the virulence factors associated with N. meningitidis.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Abbott J. D., Jones D. M., Painter M. J., Young S. E. The epidemiology of meningococcal infections in England and Wales, 1912-1983. J Infect. 1985 Nov;11(3):241–257. doi: 10.1016/s0163-4453(85)93294-3. [DOI] [PubMed] [Google Scholar]
  2. Amies C. R. A modified formula for the preparation of Stuart's Transport Medium. Can J Public Health. 1967 Jul;58(7):296–300. [PubMed] [Google Scholar]
  3. Broome C. V. The carrier state: Neisseria meningitidis. J Antimicrob Chemother. 1986 Jul;18 (Suppl A):25–34. doi: 10.1093/jac/18.supplement_a.25. [DOI] [PubMed] [Google Scholar]
  4. Brown J. D., Thomas K. R. Rapid enzyme system for the identification of pathogenic Neisseria spp. J Clin Microbiol. 1985 May;21(5):857–858. doi: 10.1128/jcm.21.5.857-858.1985. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Cartwright K. A., Stuart J. M., Noah N. D. An outbreak of meningococcal disease in Gloucestershire. Lancet. 1986 Sep 6;2(8506):558–561. doi: 10.1016/s0140-6736(86)90124-8. [DOI] [PubMed] [Google Scholar]
  6. Densen P., Weiler J. M., Griffiss J. M., Hoffmann L. G. Familial properdin deficiency and fatal meningococcemia. Correction of the bactericidal defect by vaccination. N Engl J Med. 1987 Apr 9;316(15):922–926. doi: 10.1056/NEJM198704093161506. [DOI] [PubMed] [Google Scholar]
  7. Faur Y. C., Weisburd M. H., Wilson M. E., May P. S. A new medium for the isolation of pathogenic Neisseria (NYC medium). I. Formulation and comparisons with standard media. Health Lab Sci. 1973 Apr;10(2):44–54. [PubMed] [Google Scholar]
  8. Frasch C. E., Zollinger W. D., Poolman J. T. Serotype antigens of Neisseria meningitidis and a proposed scheme for designation of serotypes. Rev Infect Dis. 1985 Jul-Aug;7(4):504–510. doi: 10.1093/clinids/7.4.504. [DOI] [PubMed] [Google Scholar]
  9. Fraser P. K., Bailey G. K., Abbott J. D., Gill J. B., Walker D. J. The meningococcal carrier-rate. Lancet. 1973 Jun 2;1(7814):1235–1237. doi: 10.1016/s0140-6736(73)90541-2. [DOI] [PubMed] [Google Scholar]
  10. Greenwood B. M., Greenwood A. M., Bradley A. K., Williams K., Hassan-King M., Shenton F. C., Wall R. A., Hayes R. J. Factors influencing susceptibility to meningococcal disease during an epidemic in The Gambia, West Africa. J Infect. 1987 Mar;14(2):167–184. doi: 10.1016/s0163-4453(87)92052-4. [DOI] [PubMed] [Google Scholar]
  11. Greenwood B. M., Hassan-King M., Whittle H. C. Prevention of secondary cases of meningococcal disease in household contacts by vaccination. Br Med J. 1978 May 20;1(6123):1317–1319. doi: 10.1136/bmj.1.6123.1317. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Poolman J. T., Lind I., Jónsdóttir K., Frøholm L. O., Jones D. M., Zanen H. C. Meningococcal serotypes and serogroup B disease in north-west Europe. Lancet. 1986 Sep 6;2(8506):555–558. doi: 10.1016/s0140-6736(86)90123-6. [DOI] [PubMed] [Google Scholar]
  13. Wenzel R. P., Davies J. A., Mitzel J. R., Beam W. E., Jr Non-usefulness of meningococcal carriage-rates. Lancet. 1973 Jul;2(7822):205–205. doi: 10.1016/s0140-6736(73)93037-7. [DOI] [PubMed] [Google Scholar]
  14. Whittle H. C., Oduloju A., Evans-Jones G., Greenwood B. M. Evidence for familial immune defect in meningococcal meningitis. Br Med J. 1976 May 22;1(6020):1247–1250. doi: 10.1136/bmj.1.6020.1247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Young L. S., LaForce F. M., Head J. J., Feeley J. C., Bennett J. V. A simultaneous outbreak of meningococcal and influenza infections. N Engl J Med. 1972 Jul 6;287(1):5–9. doi: 10.1056/NEJM197207062870102. [DOI] [PubMed] [Google Scholar]

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