Abstract
In March 1988 a general practitioner notified two cases of hepatitis A in a private boarding school. Epidemiological investigation, including testing for salivary antibodies revealed a further five cases and established immunity to, and recent infection with, hepatitis A virus (HAV). The pattern of the outbreak was described. A number of practices which would encourage cross-infection were corrected. Normal human immunoglobulin was given to contacts. Repeat salivary testing 10 weeks later revealed that two more boys had become reactive for anti-HAV, though at a low titre. These may have been serological responses to HAV infection modified by the passive immunization.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Conrad M. E., Lemon S. M. Prevention of endemic icteric viral hepatitis by administration of immune serum gamma globulin. J Infect Dis. 1987 Jul;156(1):56–63. doi: 10.1093/infdis/156.1.56. [DOI] [PubMed] [Google Scholar]
- Hadler S. C., Erben J. J., Matthews D., Starko K., Francis D. P., Maynard J. E. Effect of immunoglobulin on hepatitis A in day-care centers. JAMA. 1983 Jan 7;249(1):48–53. [PubMed] [Google Scholar]
- Hadler S. C., McFarland L. Hepatitis in day care centers: epidemiology and prevention. Rev Infect Dis. 1986 Jul-Aug;8(4):548–557. doi: 10.1093/clinids/8.4.548. [DOI] [PubMed] [Google Scholar]
- McCaustland K. A., Bond W. W., Bradley D. W., Ebert J. W., Maynard J. E. Survival of hepatitis A virus in feces after drying and storage for 1 month. J Clin Microbiol. 1982 Nov;16(5):957–958. doi: 10.1128/jcm.16.5.957-958.1982. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Parry J. V., Farrington C. P., Perry K. R., Waight P. A., Mortimer P. P., Miller E. Rational programme for screening travellers for antibodies to hepatitis A virus. Lancet. 1988 Jun 25;1(8600):1447–1449. doi: 10.1016/s0140-6736(88)92250-7. [DOI] [PubMed] [Google Scholar]
- Parry J. V., Perry K. R., Mortimer P. P. Sensitive assays for viral antibodies in saliva: an alternative to tests on serum. Lancet. 1987 Jul 11;2(8550):72–75. doi: 10.1016/s0140-6736(87)92737-1. [DOI] [PubMed] [Google Scholar]