Abstract
In the spring term of 1985 there was a protracted outbreak of upper respiratory tract febrile illness consistent with a clinical diagnosis of influenza in a boys' boarding school, which lasted from 23 January to 29 March. Although influenza virus infection was confirmed in 89% of cases in the first half of the term, 53% of the cases which occurred in the second half of the term had no evidence of infection with influenza virus. Between 5 February and 31 March 28 boys presented with skin rashes consistent with a clinical diagnosis of erythema infectiosum; 68% of these were associated with parvovirus B19. Investigation of the cases of clinical influenza with no identified respiratory pathogen revealed a 58% infection rate with B19. B19 DNA was identified in either throat swabs or acute stage bloods of nine pupils with influenza-like symptoms. Cohort studies revealed that 44% of pupils aged 15-16 years were immune before the outbreak compared with only 17% of pupils aged 11-12 years. Infection in the younger group was common and was associated with influenza-like illnesses as well as rashes. Forty-eight per cent of those who did not report any symptoms were also infected with B19.
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- Anderson M. J., Higgins P. G., Davis L. R., Willman J. S., Jones S. E., Kidd I. M., Pattison J. R., Tyrrell D. A. Experimental parvoviral infection in humans. J Infect Dis. 1985 Aug;152(2):257–265. doi: 10.1093/infdis/152.2.257. [DOI] [PubMed] [Google Scholar]
- Anderson M. J., Jones S. E., Minson A. C. Diagnosis of human parvovirus infection by dot-blot hybridization using cloned viral DNA. J Med Virol. 1985 Feb;15(2):163–172. doi: 10.1002/jmv.1890150209. [DOI] [PubMed] [Google Scholar]
- Anderson M. J., Lewis E., Kidd I. M., Hall S. M., Cohen B. J. An outbreak of erythema infectiosum associated with human parvovirus infection. J Hyg (Lond) 1984 Aug;93(1):85–93. doi: 10.1017/s0022172400060964. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Cohen B. J., Mortimer P. P., Pereira M. S. Diagnostic assays with monoclonal antibodies for the human serum parvovirus-like virus (SPLV). J Hyg (Lond) 1983 Aug;91(1):113–130. doi: 10.1017/s0022172400060095. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies J. R., Grilli E. A. Natural or vaccine-induced antibody as a predictor of immunity in the face of natural challenge with influenza viruses. Epidemiol Infect. 1989 Apr;102(2):325–333. doi: 10.1017/s0950268800030004. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Davies J. R., Grilli E. A., Smith A. J. Infection with influenza A H1N1. 2. The effect of past experience on natural challenge. J Hyg (Lond) 1986 Apr;96(2):345–352. doi: 10.1017/s0022172400066092. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Grilli E. A., Smith A. J. The use of a radial haemolysis test for neuraminidase antibodies in the diagnosis of influenza A infection. J Hyg (Lond) 1983 Aug;91(1):147–156. doi: 10.1017/s0022172400060125. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Hoskins T. W., Davies J. R., Smith A. J., Allchin A., Miller C. L., Pollock T. M. Influenza at Christ's Hospital: March, 1974. Lancet. 1976 Jan 17;1(7951):105–108. doi: 10.1016/s0140-6736(76)93151-2. [DOI] [PubMed] [Google Scholar]
- Hoskins T. W., Davies J. R., Smith A. J., Miller C. L., Allchin A. Assessment of inactivated influenza-A vaccine after three outbreaks of influenza A at Christ's Hospital. Lancet. 1979 Jan 6;1(8106):33–35. doi: 10.1016/s0140-6736(79)90468-9. [DOI] [PubMed] [Google Scholar]