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. 2004;115:289–303.

HIV Evolution and Escape.

Douglas D Richman 1, Susan J Little 1, Davey M Smith 1, Terri Wrin 1, Christos Petropoulos 1, Joseph K Wong 1
PMCID: PMC2263778  PMID: 17060974

Abstract

Human immunodeficiency virus (HIV) exemplifies the principles of Darwinian evolution with a telescoped chronology. Because of its high mutation rate and remarkably high rates of replication, evolution can be appreciated over periods of days in contrast to the durations conceived of by Darwin. Certain selective pressures that drive the evolution of HIV include chemotherapy, anatomic compartmentalization and the immune response. Examples of these selective forces on HIV evolution are described.

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Selected References

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