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. 1993 Oct;111(2):307–313. doi: 10.1017/s0950268800057010

Mycoplasma pulmonis infection of the murine oropharynx protects against subsequent vaginal colonization.

P M Furr 1, D Taylor-Robinson 1
PMCID: PMC2271378  PMID: 8405157

Abstract

Intranasal inoculation of 12 young adult mice (strain TO) with Mycoplasma pulmonis protected all of them against vaginal colonization when they were challenged intravaginally 60 days later with the same mycoplasmal strain. In contrast, all 15 mice without a respiratory infection became colonized vaginally (geometric mean titre [GMT] 4.6 x 10(6) colour-changing units [c.c.u.]) when challenged in the same way. The GMT of serum antibody, measured by a microimmunofluorescence technique, prior to challenge was 200 and 8 for the oropharyngeally infected and unexposed mice, respectively. The GMT of antibody in vaginal washings from the two groups was 6 and 3, respectively. All four nude BALB/c mice were susceptible to vaginal colonization (GMT 5.6 x 10(6) c.c.u.) after oropharyngeal infection (GMT 5.1 x 10(4) c.c.u.) resulting from intranasal inoculation, as were all six nude mice (vaginal GMT 1.4 x 10(7) c.c.u.) that had not been inoculated intranasally. In contrast, all ten of their immunocompetent counterparts were resistant to vaginal colonization after oropharyngeal infection (GMT 1.3 x 10(3) c.c.u.), whereas all nine such mice that had not been infected oropharyngeally were susceptible to vaginal colonization (GMT 7.6 x 10(6) c.c.u.). These results show the important role that a respiratory infection has in protecting the vagina against colonization and that protection is dependent on a functioning T-lymphocyte system.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker D. A., Plotkin S. A. Enhancement of vaginal infection in mice by herpes simplex virus type II with progesterone. Proc Soc Exp Biol Med. 1978 Jun;158(2):131–134. doi: 10.3181/00379727-158-40156. [DOI] [PubMed] [Google Scholar]
  2. Barden J. A., Tully J. G. Experimental arthritis in mice with Mycoplasma pulmonis. J Bacteriol. 1969 Oct;100(1):5–10. doi: 10.1128/jb.100.1.5-10.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cole B. C., Golightly-Rowland L., Ward J. R. Arthritis of mice induced by Mycoplasma pulmonis: humoral antibody and lymphocyte responses of CBA mice. Infect Immun. 1975 Nov;12(5):1083–1092. doi: 10.1128/iai.12.5.1083-1092.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Dallo S. F., Chavoya A., Su C. J., Baseman J. B. DNA and protein sequence homologies between the adhesins of Mycoplasma genitalium and Mycoplasma pneumoniae. Infect Immun. 1989 Apr;57(4):1059–1065. doi: 10.1128/iai.57.4.1059-1065.1989. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Furr P. M., Taylor-Robinson D. Enhancement of experimental Mycoplasma pulmonis infection of the mouse genital tract by progesterone treatment. J Hyg (Lond) 1984 Apr;92(2):139–144. doi: 10.1017/s0022172400064147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Furr P. M., Taylor-Robinson D. Factors influencing the ability of different mycoplasmas to colonize the genital tract of hormone-treated female mice. Int J Exp Pathol. 1993 Feb;74(1):97–101. [PMC free article] [PubMed] [Google Scholar]
  7. Furr P. M., Taylor-Robinson D. Microimmunofluorescence technique for detection of antibody to Mycoplasma genitalium. J Clin Pathol. 1984 Sep;37(9):1072–1074. doi: 10.1136/jcp.37.9.1072. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lind K. Serological cross-reactions between "Mycoplasma genitalium" and M. pneumoniae. Lancet. 1982 Nov 20;2(8308):1158–1159. doi: 10.1016/s0140-6736(82)92809-4. [DOI] [PubMed] [Google Scholar]
  9. Manchee R. J., Taylor-Robinson D. Haemadsorption and haemagglutination by mycoplasmas. J Gen Microbiol. 1968 Mar;50(3):465–478. doi: 10.1099/00221287-50-3-465. [DOI] [PubMed] [Google Scholar]
  10. Taylor-Robinson D., Furr P. M. Immunity to mycoplasmal infection of the genital tract: a mouse model. Immunology. 1986 Jun;58(2):239–243. [PMC free article] [PubMed] [Google Scholar]
  11. Taylor-Robinson D., Furr P. M. Urinary-tract infection by Mycoplasma pulmonis in mice and its wider implications. J Hyg (Lond) 1986 Jun;96(3):439–446. doi: 10.1017/s0022172400066213. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Taylor G., Taylor-Robinson D. Effects of active and passive immunization on Mycoplasma pulmonis-induced pneumonia in mice. Immunology. 1976 May;30(5):611–618. [PMC free article] [PubMed] [Google Scholar]

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