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. 1994 Apr;112(2):421–437. doi: 10.1017/s0950268800057848

Antigenicity and immunogenicity of equine influenza vaccines containing a Carbomer adjuvant.

J A Mumford 1, H Wilson 1, D Hannant 1, D M Jessett 1
PMCID: PMC2271453  PMID: 8150017

Abstract

Equine influenza vaccines containing inactivated whole virus and Carbomer adjuvant stimulated higher levels and longer lasting antibody to haemagglutinin in ponies than vaccines of equivalent antigenic content containing aluminium phosphate adjuvants. Five months after the third dose of vaccine containing Carbomer adjuvant, ponies were protected against clinical disease induced by an aerosol of virulent influenza virus (A/equine/Newmarket/79, H3N8). In contrast ponies which received vaccine containing aluminium phosphate adjuvant were susceptible to infection and disease. There was an inverse correlation between prechallenge levels of antibody detected by single radial haemolysis (SRH) and duration of virus excretion, pyrexia and coughing. All ponies with antibody levels equivalent to SRH zones of > or = 154 mm2 were protected against infection and all those with levels > or = 85 mm2 were protected from disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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