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. 1995 Dec;115(3):581–589. doi: 10.1017/s095026880005874x

Study of the effectiveness of influenza vaccination in the elderly in the epidemic of 1989-90 using a general practice database.

D M Fleming 1, J M Watson 1, S Nicholas 1, G E Smith 1, A V Swan 1
PMCID: PMC2271576  PMID: 8557090

Abstract

The effectiveness of influenza vaccination in preventing serious illness and death was determined in an elderly population during the influenza epidemic of was determined in an elderly population during the influenza epidemic of was determined in an elderly population during the influenza epidemic of 1989-90. A retrospective cohort study was carried out using computerized general practitioner records on nearly 10,000 patients aged 55 years and over. After adjustment for potential confounding factors, recent immunization was found to have a protective effect of 75% (95% confidence intervals: 21-92%) against death. Protection did not appear to vary with either age or the presence of underlying chronic disease. As the complications of influenza are most common in those with underlying chronic disease, the study findings are consistent with the recommended policy for the use of influenza vaccine in the UK. Further work is necessary to determine the cost-effectiveness of extending immunization to other groups.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Fedson D. S., Wajda A., Nicol J. P., Hammond G. W., Kaiser D. L., Roos L. L. Clinical effectiveness of influenza vaccination in Manitoba. JAMA. 1993 Oct 27;270(16):1956–1961. [PubMed] [Google Scholar]
  2. Fleming D. M., Cross K. W. Respiratory syncytial virus or influenza? Lancet. 1993 Dec 18;342(8886-8887):1507–1510. doi: 10.1016/s0140-6736(05)80082-0. [DOI] [PubMed] [Google Scholar]
  3. Foster D. A., Talsma A., Furumoto-Dawson A., Ohmit S. E., Margulies J. R., Arden N. H., Monto A. S. Influenza vaccine effectiveness in preventing hospitalization for pneumonia in the elderly. Am J Epidemiol. 1992 Aug 1;136(3):296–307. doi: 10.1093/oxfordjournals.aje.a116495. [DOI] [PubMed] [Google Scholar]
  4. Monto A. S. Influenza vaccines for the elderly. N Engl J Med. 1994 Sep 22;331(12):807–808. doi: 10.1056/NEJM199409223311212. [DOI] [PubMed] [Google Scholar]
  5. Nichol K. L., Margolis K. L., Wuorenma J., Von Sternberg T. The efficacy and cost effectiveness of vaccination against influenza among elderly persons living in the community. N Engl J Med. 1994 Sep 22;331(12):778–784. doi: 10.1056/NEJM199409223311206. [DOI] [PubMed] [Google Scholar]
  6. Patriarca P. A., Weber J. A., Parker R. A., Hall W. N., Kendal A. P., Bregman D. J., Schonberger L. B. Efficacy of influenza vaccine in nursing homes. Reduction in illness and complications during an influenza A (H3N2) epidemic. JAMA. 1985 Feb 22;253(8):1136–1139. [PubMed] [Google Scholar]
  7. Shann F. Modern vaccines. Pneumococcus and influenza. Lancet. 1990 Apr 14;335(8694):898–901. doi: 10.1016/0140-6736(90)90489-r. [DOI] [PubMed] [Google Scholar]

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