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. 1990 Feb;104(1):151–156. doi: 10.1017/s0950268800054637

High incidence of subacute sclerosing panencephalitis in south India.

V Saha 1, T J John 1, P Mukundan 1, C Gnanamuthu 1, S Prabhakar 1, G Arjundas 1, Z A Sayeed 1, G Kumaresan 1, K Srinivas 1
PMCID: PMC2271732  PMID: 2307182

Abstract

During 1983-7 a clinical diagnosis of subacute sclerosing panencephalitis (SSPE) was confirmed by the detection of measles virus haemagglutination inhibiting antibody in the cerebrospinal fluid (CSF) in 81 subjects resident in Tamilnadu. The antibody titre (reciprocol of the end-point dilution) in the CSF ranged from 2 to 32 and in the sera from 8 to 2048. The CSF:serum ratios of titres were 1:4-1:64 in 80 cases and 1:128 in one case. The median age at onset of SSPE was 10 years and 97% of cases were diagnosed at stage 2 and beyond. Based on the geographic distribution of 72 cases in an estimated population of 8.4 million, the annual incidence of SSPE was calculated to be 2.14 per million population, or 4.3 cases per million children below 20 years. Assuming that only 10% of all cases would have reached the level of laboratory diagnosis, the incidence may be as high as 21 cases per million population.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bellman M. H., Dick G. Subacute sclerosing panencephalitis. Postgrad Med J. 1978 Sep;54(635):587–590. doi: 10.1136/pgmj.54.635.587. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cherian T., Joseph A., John T. J. Low antibody response in infants with measles and children with subclinical measles virus infection. J Trop Med Hyg. 1984 Feb;87(1):27–31. [PubMed] [Google Scholar]
  3. Haddad F. S., Risk W. S., Jabbour J. T. Letter: Subacute sclerosing panencephalitis in the Middle East. Lancet. 1974 Oct 26;2(7887):1025–1025. doi: 10.1016/s0140-6736(74)92135-7. [DOI] [PubMed] [Google Scholar]
  4. Jabbour J. T., Duenas D. A., Sever J. L., Krebs H. M., Horta-Barbosa L. Epidemiology of subacute sclerosing panencephalitis (SSPE). A report of the SSPE registry. JAMA. 1972 May 15;220(7):959–962. [PubMed] [Google Scholar]
  5. Jabbour J. T., Garcia J. H., Lemmi H., Ragland J., Duenas D. A., Sever J. L. Subacute sclerosing panencephalitis. A multidisciplinary study of eight cases. JAMA. 1969 Mar 24;207(12):2248–2254. doi: 10.1001/jama.207.12.2248. [DOI] [PubMed] [Google Scholar]
  6. John T. J., Devarajan L. V. Priority for measles vaccine. Indian Pediatr. 1973 Feb;10(2):57–58. [PubMed] [Google Scholar]
  7. John T. J., Joseph A., George T. I., Radhakrishnan J., Singh R. P., George K. Epidemiology and prevention of measles in rural south India. Indian J Med Res. 1980 Aug;72:153–158. [PubMed] [Google Scholar]
  8. Kondo K., Takasu T., Ahmed A. Neurological diseases in Karachi, Pakistan--elevated occurrence of subacute sclerosing panencephalitis. Neuroepidemiology. 1988;7(2):66–80. doi: 10.1159/000110138. [DOI] [PubMed] [Google Scholar]
  9. LANGMUIR A. D. Medical importance of measles. Am J Dis Child. 1962 Mar;103:224–226. doi: 10.1001/archpedi.1962.02080020236005. [DOI] [PubMed] [Google Scholar]
  10. Modlin J. F., Halsey N. A., Eddins D. L., Conrad J. L., Jabbour J. T., Chien L., Robinson H. Epidemiology of subacute sclerosing panencephalitis. J Pediatr. 1979 Feb;94(2):231–236. doi: 10.1016/s0022-3476(79)80829-x. [DOI] [PubMed] [Google Scholar]
  11. Piereira S. M., Benjamin V. Measles in a South Indian community. Trop Geogr Med. 1972 Jun;24(2):124–129. [PubMed] [Google Scholar]
  12. Robbins S. J., Appleton B., Fiumara F., Burke C. Subacute sclerosing panencephalitis (SSPE): a report of 16 cases. Aust N Z J Med. 1984 Apr;14(2):126–130. doi: 10.1111/j.1445-5994.1984.tb04274.x. [DOI] [PubMed] [Google Scholar]
  13. Siddiqi N., Ghosh S., Berry A. M. The natural history of measles in a low-income urban community in South Delhi. Indian Pediatr. 1974 Aug;11(8):557–562. [PubMed] [Google Scholar]
  14. Soffer D., Rannon L., Alter M., Kahana E., Feldman S. Subacute sclerosing panencephalitis: an epidemiologic study in Israel. Am J Epidemiol. 1976 Jan;103(1):67–74. doi: 10.1093/oxfordjournals.aje.a112206. [DOI] [PubMed] [Google Scholar]

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