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. 1990 Apr;104(2):289–296. doi: 10.1017/s095026880005946x

Production of IgM antibody to HHV6 in reactivation and primary infection.

J D Fox 1, P Ward 1, M Briggs 1, W Irving 1, T G Stammers 1, R S Tedder 1
PMCID: PMC2271749  PMID: 2157605

Abstract

The cross-reaction of HHV6 antibody with that to the other herpesviruses was studied in 96 blood donors whose sera were tested for IgG antibody to human herpesvirus type 6 (HHV6), cytomegalovirus (CMV), Epstein-Barr virus (EBV), varicella zostervirus (VZV) and herpes simplex virus (HSV). No correlation was found between IgG antibody to HHV6 and that to any of the other herpesviruses in these individuals. Antibodies to HHV6 and CMV were measured in patients undergoing documented serological responses to HHV6. Eleven cases of primary HHV6 infection associated with roseola infantum in babies, 1 of whom suffered from gastroenteritis as well as pyrexia and rash, are reported. Three cases of HHV6 reactivation, 1 in a 3-year-old child and 2 in adults, 1 of whom simultaneously underwent a primary CMV infection are also reported. Our results suggest that indirect immunofluorescence is a specific way of measuring HHV6 antibody, that HHV6 IgG and IgM can be detected in the absence of antibody to CMV and that HHV6 IgM is present both in primary HHV6 infections and in reactivations.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Briggs M., Fox J., Tedder R. S. Age prevalence of antibody to human herpesvirus 6. Lancet. 1988 May 7;1(8593):1058–1059. doi: 10.1016/s0140-6736(88)91883-1. [DOI] [PubMed] [Google Scholar]
  2. Downing R. G., Sewankambo N., Serwadda D., Honess R., Crawford D., Jarrett R., Griffin B. E. Isolation of human lymphotropic herpesviruses from Uganda. Lancet. 1987 Aug 15;2(8555):390–390. doi: 10.1016/s0140-6736(87)92403-2. [DOI] [PubMed] [Google Scholar]
  3. Irving W. L., Cunningham A. L., Keogh A., Chapman J. R. Antibody to both human herpesvirus 6 and cytomegalovirus. Lancet. 1988 Sep 10;2(8611):630–631. doi: 10.1016/s0140-6736(88)90669-1. [DOI] [PubMed] [Google Scholar]
  4. Kirchesch H., Mertens T., Burkhardt U., Kruppenbacher J. P., Höffken A., Eggers H. J. Seroconversion against human herpesvirus-6 (and other herpesviruses) and clinical illness. Lancet. 1988 Jul 30;2(8605):273–274. doi: 10.1016/s0140-6736(88)92557-3. [DOI] [PubMed] [Google Scholar]
  5. Knowles W. A., Gardner S. D. High prevalence of antibody to human herpesvirus-6 and seroconversion associated with rash in two infants. Lancet. 1988 Oct 15;2(8616):912–913. doi: 10.1016/s0140-6736(88)92522-6. [DOI] [PubMed] [Google Scholar]
  6. Larcher C., Huemer H. P., Margreiter R., Dierich M. P. Serological crossreaction of human herpesvirus-6 with cytomegalovirus. Lancet. 1988 Oct 22;2(8617):963–964. doi: 10.1016/s0140-6736(88)92631-1. [DOI] [PubMed] [Google Scholar]
  7. Niederman J. C., Liu C. R., Kaplan M. H., Brown N. A. Clinical and serological features of human herpesvirus-6 infection in three adults. Lancet. 1988 Oct 8;2(8615):817–819. doi: 10.1016/s0140-6736(88)92783-3. [DOI] [PubMed] [Google Scholar]
  8. Salahuddin S. Z., Ablashi D. V., Markham P. D., Josephs S. F., Sturzenegger S., Kaplan M., Halligan G., Biberfeld P., Wong-Staal F., Kramarsky B. Isolation of a new virus, HBLV, in patients with lymphoproliferative disorders. Science. 1986 Oct 31;234(4776):596–601. doi: 10.1126/science.2876520. [DOI] [PubMed] [Google Scholar]
  9. Stammers T. G. Roseola infantum--the neglected exanthem. Practitioner. 1988 May 9;232(1448):541-2, 544. [PubMed] [Google Scholar]
  10. Tedder R. S., Briggs M., Cameron C. H., Honess R., Robertson D., Whittle H. A novel lymphotropic herpesvirus. Lancet. 1987 Aug 15;2(8555):390–392. doi: 10.1016/s0140-6736(87)92404-4. [DOI] [PubMed] [Google Scholar]
  11. Yamanishi K., Okuno T., Shiraki K., Takahashi M., Kondo T., Asano Y., Kurata T. Identification of human herpesvirus-6 as a causal agent for exanthem subitum. Lancet. 1988 May 14;1(8594):1065–1067. doi: 10.1016/s0140-6736(88)91893-4. [DOI] [PubMed] [Google Scholar]

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