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. 1986 Dec;32:2633–2637.

Prescribing Drugs for the Elderly: Reaching Therapeutic Goals

Harold G Preiksaitis, Michael Gordon
PMCID: PMC2327473  PMID: 20469453

Abstract

The positive aspects of drug use by the geriatric population are balanced by concerns about harmful effects of the drugs. Physiologic changes that accompany aging alter the pharmacology of many drugs, but problems of compliance, adverse reactions and polypharmacy are of equal importance. The authors of this article examine aspects of drug delivery in the elderly and make suggestions for improving prescribing practices.

Keywords: geriatrics, pharmacotherapy, prescribing

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander N., Goodwin J. S., Currie C. Comparison of admission and discharge medications in two geriatric populations. J Am Geriatr Soc. 1985 Dec;33(12):827–832. doi: 10.1111/j.1532-5415.1985.tb05434.x. [DOI] [PubMed] [Google Scholar]
  2. Ferry M. E., Lamy P. P., Becker L. A. Physicians' knowledge of prescribing for the elderly. A study of primary care physicians in Pennsylvania. J Am Geriatr Soc. 1985 Sep;33(9):616–625. doi: 10.1111/j.1532-5415.1985.tb06318.x. [DOI] [PubMed] [Google Scholar]
  3. Gordon M., Goldenberg L. M. Clinical digoxin toxicity in the aged in association with co-administered verapamil. A report of two cases and review of the literature. J Am Geriatr Soc. 1986 Sep;34(9):659–662. doi: 10.1111/j.1532-5415.1986.tb04908.x. [DOI] [PubMed] [Google Scholar]
  4. Greenblatt D. J., Sellers E. M., Koch-Weser J. Importance of protein binding for the interpretation of serum or plasma drug concentrations. J Clin Pharmacol. 1982 May-Jun;22(5-6):259–263. doi: 10.1002/j.1552-4604.1982.tb02671.x. [DOI] [PubMed] [Google Scholar]
  5. Greenblatt D. J., Sellers E. M., Shader R. I. Drug therapy: drug disposition in old age. N Engl J Med. 1982 May 6;306(18):1081–1088. doi: 10.1056/NEJM198205063061804. [DOI] [PubMed] [Google Scholar]
  6. Hurwitz N. Predisposing factors in adverse reactions to drugs. Br Med J. 1969 Mar 1;1(5643):536–539. doi: 10.1136/bmj.1.5643.536. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kendall M. J. A year in industry. Br J Clin Pharmacol. 1977 Feb;4(1):3–4. doi: 10.1111/j.1365-2125.1977.tb00658.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lamy P. P. The elderly and drug interactions. J Am Geriatr Soc. 1986 Aug;34(8):586–592. doi: 10.1111/j.1532-5415.1986.tb05764.x. [DOI] [PubMed] [Google Scholar]
  9. Myers M. G., Weingert M. E., Fisher R. H., Gryfe C. I., Shulman H. S. Unnecessary diuretic therapy in the elderly. Age Ageing. 1982 Nov;11(4):213–221. doi: 10.1093/ageing/11.4.213. [DOI] [PubMed] [Google Scholar]
  10. Newhouse M. T., Dolovich M. B. Control of asthma by aerosols. N Engl J Med. 1986 Oct 2;315(14):870–874. doi: 10.1056/NEJM198610023151406. [DOI] [PubMed] [Google Scholar]
  11. Reidenberg M. M., Levy M., Warner H., Coutinho C. B., Schwartz M. A., Yu G., Cheripko J. Relationship between diazepam dose, plasma level, age, and central nervous system depression. Clin Pharmacol Ther. 1978 Apr;23(4):371–374. doi: 10.1002/cpt1978234371. [DOI] [PubMed] [Google Scholar]
  12. Roth H. P., Caron H. S. Accuracy of doctors' estimates and patients' statements on adherence to a drug regimen. Clin Pharmacol Ther. 1978 Mar;23(3):361–370. doi: 10.1002/cpt1978233361. [DOI] [PubMed] [Google Scholar]
  13. SCHWARTZ D., WANG M., ZEITZ L., GOSS M. E. Medication errors made by elderly, chronically ill patients. Am J Public Health Nations Health. 1962 Dec;52:2018–2029. doi: 10.2105/ajph.52.12.2018. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Sherman F. T. Tamper-resistant packaging: is it elder-resistant, too? J Am Geriatr Soc. 1985 Feb;33(2):136–141. doi: 10.1111/j.1532-5415.1985.tb02280.x. [DOI] [PubMed] [Google Scholar]
  15. Sherman F. T., Warach J. D., Libow L. S. Child-resistant containers for the elderly? JAMA. 1979 Mar 9;241(10):1001–1002. [PubMed] [Google Scholar]
  16. Stewart R. B., Cluff L. E. A review of medication errors and compliance in ambulant patients. Clin Pharmacol Ther. 1972 Jul-Aug;13(4):463–468. doi: 10.1002/cpt1972134463. [DOI] [PubMed] [Google Scholar]
  17. Timbrell J. A., Harland S. J. Identification and quantitation of hydrazine in the urine of patients treated with hydralazine. Clin Pharmacol Ther. 1979 Jul;26(1):81–88. doi: 10.1002/cpt197926181. [DOI] [PubMed] [Google Scholar]
  18. Vasko M. R., Cartwright D. B., Knochel J. P., Nixon J. V., Brater D. C. Furosemide absorption altered in decompensated congestive heart failure. Ann Intern Med. 1985 Mar;102(3):314–318. doi: 10.7326/0003-4819-102-3-314. [DOI] [PubMed] [Google Scholar]
  19. Wilkins C. E., Khurana M. S. Digitalis withdrawal in elderly nursing home patients. J Am Geriatr Soc. 1985 Dec;33(12):850–851. doi: 10.1111/j.1532-5415.1985.tb05438.x. [DOI] [PubMed] [Google Scholar]

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