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. 1996 Jan 20;312(7024):156–160. doi: 10.1136/bmj.312.7024.156

Fetal growth and cardiovascular risk factors in Jamaican schoolchildren.

T E Forrester 1, R J Wilks 1, F I Bennett 1, D Simeon 1, C Osmond 1, M Allen 1, A P Chung 1, P Scott 1
PMCID: PMC2349813  PMID: 8563535

Abstract

OBJECTIVE--To determine relation between schoolchildren's blood pressure, glycated haemoglobin level, and cholesterol concentration and their anthropometry, socioeconomic status, and birth measurements. DESIGN--Retrospective cohort study. SETTING--27 schools closest to University Hospital of the West Indies, Kingston, Jamaica. SUBJECTS--2337 children aged 6-16 years who were born at university hospital were recruited, and their birth records were recovered: 1610 had suitable records, 659 had records including birth length, and 610 of these were prepubertal. MAIN OUTCOME MEASURES--Blood pressure, glycated haemoglobin level, serum cholesterol concentration, anthropometry at birth, current anthropometry, and socioeconomic status. RESULTS--Multiple regression analysis showed that children's systolic blood pressure was inversely related to their birth weight (P < 0.0001) and directly related to their current weight. Glycated haemoglobin level was higher in children with thicker triceps skinfolds (P < 0.001) and who had been shorter at birth (P = 0.003). Serum cholesterol concentration was inversely related to current height (P = 0.001) and to length at birth (P = 0.09) and was directly related to triceps skinfold thickness and higher socioeconomic status (P < 0.001). CONCLUSIONS--Blood pressure in childhood was inversely related to birth weight and directly to current weight. Glycaemic control and serum cholesterol were related to short length at birth, height deficit in childhood, and childhood obesity.

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Selected References

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  1. Allain C. C., Poon L. S., Chan C. S., Richmond W., Fu P. C. Enzymatic determination of total serum cholesterol. Clin Chem. 1974 Apr;20(4):470–475. [PubMed] [Google Scholar]
  2. Anderson A. J., Sobocinski K. A., Freedman D. S., Barboriak J. J., Rimm A. A., Gruchow H. W. Body fat distribution, plasma lipids, and lipoproteins. Arteriosclerosis. 1988 Jan-Feb;8(1):88–94. doi: 10.1161/01.atv.8.1.88. [DOI] [PubMed] [Google Scholar]
  3. Barker D. J., Bull A. R., Osmond C., Simmonds S. J. Fetal and placental size and risk of hypertension in adult life. BMJ. 1990 Aug 4;301(6746):259–262. doi: 10.1136/bmj.301.6746.259. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Barker D. J., Martyn C. N., Osmond C., Hales C. N., Fall C. H. Growth in utero and serum cholesterol concentrations in adult life. BMJ. 1993 Dec 11;307(6918):1524–1527. doi: 10.1136/bmj.307.6918.1524. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Barker D. J., Osmond C., Golding J., Kuh D., Wadsworth M. E. Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. BMJ. 1989 Mar 4;298(6673):564–567. doi: 10.1136/bmj.298.6673.564. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Beaglehole R., Salmond C. E., Eyles E. F. A longitudianl study of blood pressure in Polynesian children. Am J Epidemiol. 1977 Jan;105(1):87–89. doi: 10.1093/oxfordjournals.aje.a112359. [DOI] [PubMed] [Google Scholar]
  7. Ben-Shlomo Y., Smith G. D. Deprivation in infancy or in adult life: which is more important for mortality risk? Lancet. 1991 Mar 2;337(8740):530–534. doi: 10.1016/0140-6736(91)91307-g. [DOI] [PubMed] [Google Scholar]
  8. Campos H., Bailey S. M., Gussak L. S., Siles X., Ordovas J. M., Schaefer E. J. Relations of body habitus, fitness level, and cardiovascular risk factors including lipoproteins and apolipoproteins in a rural and urban Costa Rican population. Arterioscler Thromb. 1991 Jul-Aug;11(4):1077–1088. doi: 10.1161/01.atv.11.4.1077. [DOI] [PubMed] [Google Scholar]
  9. Clarke W. R., Schrott H. G., Leaverton P. E., Connor W. E., Lauer R. M. Tracking of blood lipids and blood pressures in school age children: the Muscatine study. Circulation. 1978 Oct;58(4):626–634. doi: 10.1161/01.cir.58.4.626. [DOI] [PubMed] [Google Scholar]
  10. Freedman D. S., Srinivasan S. R., Cresanta J. L., Webber L. S., Berenson G. S. Cardiovascular risk factors from birth to 7 years of age: the Bogalusa Heart Study. Serum lipids and lipoproteins. Pediatrics. 1987 Nov;80(5 Pt 2):789–796. [PubMed] [Google Scholar]
  11. Hales C. N., Barker D. J., Clark P. M., Cox L. J., Fall C., Osmond C., Winter P. D. Fetal and infant growth and impaired glucose tolerance at age 64. BMJ. 1991 Oct 26;303(6809):1019–1022. doi: 10.1136/bmj.303.6809.1019. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Hall P. M., Cook J. G., Gould B. J. An inexpensive, rapid and precise affinity chromatography method for the measurement of glycosylated haemoglobins. Ann Clin Biochem. 1983 May;20(Pt 3):129–135. doi: 10.1177/000456328302000301. [DOI] [PubMed] [Google Scholar]
  13. Lauer R. M., Burns T. L., Clarke W. R. Assessing children's blood pressure--considerations of age and body size: the Muscatine Study. Pediatrics. 1985 Jun;75(6):1081–1090. [PubMed] [Google Scholar]
  14. Lauer R. M., Burns T. L., Clarke W. R., Mahoney L. T. Childhood predictors of future blood pressure. Hypertension. 1991 Sep;18(3 Suppl):I74–I81. doi: 10.1161/01.hyp.18.3_suppl.i74. [DOI] [PubMed] [Google Scholar]
  15. Lauer R. M., Clarke W. R., Beaglehole R. Level, trend, and variability of blood pressure during childhood: the Muscatine study. Circulation. 1984 Feb;69(2):242–249. doi: 10.1161/01.cir.69.2.242. [DOI] [PubMed] [Google Scholar]
  16. Law C. M., Barker D. J., Bull A. R., Osmond C. Maternal and fetal influences on blood pressure. Arch Dis Child. 1991 Nov;66(11):1291–1295. doi: 10.1136/adc.66.11.1291. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Law C. M., Barker D. J., Osmond C., Fall C. H., Simmonds S. J. Early growth and abdominal fatness in adult life. J Epidemiol Community Health. 1992 Jun;46(3):184–186. doi: 10.1136/jech.46.3.184. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Law C. M., de Swiet M., Osmond C., Fayers P. M., Barker D. J., Cruddas A. M., Fall C. H. Initiation of hypertension in utero and its amplification throughout life. BMJ. 1993 Jan 2;306(6869):24–27. doi: 10.1136/bmj.306.6869.24. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Liu K., Ballew C., Jacobs D. R., Jr, Sidney S., Savage P. J., Dyer A., Hughes G., Blanton M. M. Ethnic differences in blood pressure, pulse rate, and related characteristics in young adults. The CARDIA study. Hypertension. 1989 Aug;14(2):218–226. doi: 10.1161/01.hyp.14.2.218. [DOI] [PubMed] [Google Scholar]
  20. Macintyre S., Watt G., West P., Ecob R. Correlates of blood pressure in 15 year olds in the west of Scotland. J Epidemiol Community Health. 1991 Jun;45(2):143–147. doi: 10.1136/jech.45.2.143. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Margetts B. M., Rowland M. G., Foord F. A., Cruddas A. M., Cole T. J., Barker D. J. The relation of maternal weight to the blood pressures of Gambian children. Int J Epidemiol. 1991 Dec;20(4):938–943. doi: 10.1093/ije/20.4.938. [DOI] [PubMed] [Google Scholar]
  22. Mueller W. H., Joos S. K., Hanis C. L., Zavaleta A. N., Eichner J., Schull W. J. The Diabetes Alert study: growth, fatness, and fat patterning, adolescence through adulthood in Mexican Americans. Am J Phys Anthropol. 1984 Aug;64(4):389–399. doi: 10.1002/ajpa.1330640404. [DOI] [PubMed] [Google Scholar]
  23. Reaven G. M. Banting lecture 1988. Role of insulin resistance in human disease. Diabetes. 1988 Dec;37(12):1595–1607. doi: 10.2337/diab.37.12.1595. [DOI] [PubMed] [Google Scholar]
  24. Rosner B., Hennekens C. H., Kass E. H., Miall W. E. Age-specific correlation analysis of longitudinal blood pressure data. Am J Epidemiol. 1977 Oct;106(4):306–313. doi: 10.1093/oxfordjournals.aje.a112466. [DOI] [PubMed] [Google Scholar]
  25. Seidman D. S., Laor A., Gale R., Stevenson D. K., Mashiach S., Danon Y. L. Birth weight, current body weight, and blood pressure in late adolescence. BMJ. 1991 May 25;302(6787):1235–1237. doi: 10.1136/bmj.302.6787.1235. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. Whincup P. H., Cook D. G., Papacosta O. Do maternal and intrauterine factors influence blood pressure in childhood? Arch Dis Child. 1992 Dec;67(12):1423–1429. doi: 10.1136/adc.67.12.1423. [DOI] [PMC free article] [PubMed] [Google Scholar]
  27. Williams S., St George I. M., Silva P. A. Intrauterine growth retardation and blood pressure at age seven and eighteen. J Clin Epidemiol. 1992 Nov;45(11):1257–1263. doi: 10.1016/0895-4356(92)90167-l. [DOI] [PubMed] [Google Scholar]

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