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. 1996 Nov 23;313(7068):1297–1300. doi: 10.1136/bmj.313.7068.1297

Effect of population mixing and socioeconomic status in England and Wales, 1979-85, on lymphoblastic leukaemia in children.

C A Stiller 1, P J Boyle 1
PMCID: PMC2352738  PMID: 8942689

Abstract

OBJECTIVE: To examine the effects of migration, diversity of migrant origins, commuting, and socioeconomic status on the incidence of acute lymphoblastic leukaemia in childhood. DESIGN: Poisson regression analysis of incidence rates in relation to the variables of interest. SETTING: The 403 county districts of England and Wales during 1979-85. SUBJECTS: Children aged under 15 years. RESULTS: There were significant trends in the incidence of lymphoblastic leukaemia at ages 0-4 and 5-9 years with the proportion of children in a district who had recently entered the district. While there was no consistent relation between the proportion of recent incomers in the total population of a district and its incidence rate, the combination of higher migration with greater diversity of origins or distance moved was associated with higher incidence in both age groups. Incidence increased significantly at age 0-4 with the level of employment in a district and at age 5-9 with the proportion of households with access to a car. No significant trends were found with commuting. CONCLUSIONS: The results for level of child migration and diversity of total migration provide evidence of an effect of population mixing on the incidence of childhood leukaemia which is not restricted to areas experiencing the most extreme levels of mixing.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Alexander F. E., McKinney P. M., Cartwright R. A. Migration patterns of children with leukaemia and non-Hodgkin's lymphoma in three areas of northern England. J Public Health Med. 1993 Mar;15(1):9–15. doi: 10.1093/oxfordjournals.pubmed.a042826. [DOI] [PubMed] [Google Scholar]
  2. Alexander F. E., Ricketts T. J., McKinney P. A., Cartwright R. A. Community lifestyle characteristics and risk of acute lymphoblastic leukaemia in children. Lancet. 1990 Dec 15;336(8729):1461–1465. doi: 10.1016/0140-6736(90)93176-p. [DOI] [PubMed] [Google Scholar]
  3. Kinlen L. J., Clarke K., Hudson C. Evidence from population mixing in British New Towns 1946-85 of an infective basis for childhood leukaemia. Lancet. 1990 Sep 8;336(8715):577–582. doi: 10.1016/0140-6736(90)93389-7. [DOI] [PubMed] [Google Scholar]
  4. Kinlen L. J., Dickson M., Stiller C. A. Childhood leukaemia and non-Hodgkin's lymphoma near large rural construction sites, with a comparison with Sellafield nuclear site. BMJ. 1995 Mar 25;310(6982):763–768. doi: 10.1136/bmj.310.6982.763. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Kinlen L. J. Epidemiological evidence for an infective basis in childhood leukaemia. Br J Cancer. 1995 Jan;71(1):1–5. doi: 10.1038/bjc.1995.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Kinlen L. J., Hudson C. M., Stiller C. A. Contacts between adults as evidence for an infective origin of childhood leukaemia: an explanation for the excess near nuclear establishments in west Berkshire? Br J Cancer. 1991 Sep;64(3):549–554. doi: 10.1038/bjc.1991.348. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Kinlen L. J., Hudson C. Childhood leukaemia and poliomyelitis in relation to military encampments in England and Wales in the period of national military service, 1950-63. BMJ. 1991 Nov 30;303(6814):1357–1362. doi: 10.1136/bmj.303.6814.1357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Kinlen L. J., O'Brien F., Clarke K., Balkwill A., Matthews F. Rural population mixing and childhood leukaemia: effects of the North Sea oil industry in Scotland, including the area near Dounreay nuclear site. BMJ. 1993 Mar 20;306(6880):743–748. doi: 10.1136/bmj.306.6880.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kinlen L. Evidence for an infective cause of childhood leukaemia: comparison of a Scottish new town with nuclear reprocessing sites in Britain. Lancet. 1988 Dec 10;2(8624):1323–1327. doi: 10.1016/s0140-6736(88)90867-7. [DOI] [PubMed] [Google Scholar]
  10. Knox E. G., Gilman E. Leukaemia clusters in Great Britain. 1. Space-time interactions. J Epidemiol Community Health. 1992 Dec;46(6):566–572. doi: 10.1136/jech.46.6.566. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Langford I. Childhood leukaemia mortality and population change in England and Wales 1969-73. Soc Sci Med. 1991;33(4):435–440. doi: 10.1016/0277-9536(91)90325-7. [DOI] [PubMed] [Google Scholar]
  12. McWhirter W. R. The relationship of incidence of childhood lymphoblastic leukaemia to social class. Br J Cancer. 1982 Oct;46(4):640–645. doi: 10.1038/bjc.1982.249. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Stiller C. A., Allen M. B., Eatock E. M. Childhood cancer in Britain: the National Registry of Childhood Tumours and incidence rates 1978-1987. Eur J Cancer. 1995 Nov;31A(12):2028–2034. doi: 10.1016/0959-8049(95)00428-9. [DOI] [PubMed] [Google Scholar]

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