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. 1996 Oct;5(5):305–323. doi: 10.1155/S0962935196000452

Cyclooxygenase-2 and its regulation in inflammation

Y S Bakhle 1,✉, R M Botting 1
PMCID: PMC2365800  PMID: 18475724

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Selected References

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  1. Akarasereenont P., Bakhle Y. S., Thiemermann C., Vane J. R. Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide. Br J Pharmacol. 1995 Jun;115(3):401–408. doi: 10.1111/j.1476-5381.1995.tb16347.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Akarasereenont P., Mitchell J. A., Appleton I., Thiemermann C., Vane J. R. Involvement of tyrosine kinase in the induction of cyclo-oxygenase and nitric oxide synthase by endotoxin in cultured cells. Br J Pharmacol. 1994 Dec;113(4):1522–1528. doi: 10.1111/j.1476-5381.1994.tb17169.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Akarasereenont P., Mitchell J. A., Bakhle Y. S., Thiemermann C., Vane J. R. Comparison of the induction of cyclooxygenase and nitric oxide synthase by endotoxin in endothelial cells and macrophages. Eur J Pharmacol. 1995 Jan 24;273(1-2):121–128. doi: 10.1016/0014-2999(94)00680-6. [DOI] [PubMed] [Google Scholar]
  4. Angel J., Berenbaum F., Le Denmat C., Nevalainen T., Masliah J., Fournier C. Interleukin-1-induced prostaglandin E2 biosynthesis in human synovial cells involves the activation of cytosolic phospholipase A2 and cyclooxygenase-2. Eur J Biochem. 1994 Nov 15;226(1):125–131. doi: 10.1111/j.1432-1033.1994.tb20033.x. [DOI] [PubMed] [Google Scholar]
  5. Appleby S. B., Ristimäki A., Neilson K., Narko K., Hla T. Structure of the human cyclo-oxygenase-2 gene. Biochem J. 1994 Sep 15;302(Pt 3):723–727. doi: 10.1042/bj3020723. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Arias-Negrete S., Keller K., Chadee K. Proinflammatory cytokines regulate cyclooxygenase-2 mRNA expression in human macrophages. Biochem Biophys Res Commun. 1995 Mar 17;208(2):582–589. doi: 10.1006/bbrc.1995.1378. [DOI] [PubMed] [Google Scholar]
  7. Astin M., Stjernschantz J., Selén G. Role of nitric oxide in PGF2 alpha-induced ocular hyperemia. Exp Eye Res. 1994 Oct;59(4):401–407. doi: 10.1006/exer.1994.1124. [DOI] [PubMed] [Google Scholar]
  8. Barker J. E., Bakhle Y. S., Anderson J., Treasure T., Piper P. J. Reciprocal inhibition of nitric oxide and prostacyclin synthesis in human saphenous vein. Br J Pharmacol. 1996 Jun;118(3):643–648. doi: 10.1111/j.1476-5381.1996.tb15449.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Barnes P. J., Adcock I. M. Transcription factors. Clin Exp Allergy. 1995 Nov;25 (Suppl 2):46–49. doi: 10.1111/j.1365-2222.1995.tb00421.x. [DOI] [PubMed] [Google Scholar]
  10. Bhattacharyya D. K., Lecomte M., Dunn J., Morgans D. J., Smith W. L. Selective inhibition of prostaglandin endoperoxide synthase-1 (cyclooxygenase-1) by valerylsalicylic acid. Arch Biochem Biophys. 1995 Feb 20;317(1):19–24. doi: 10.1006/abbi.1995.1130. [DOI] [PubMed] [Google Scholar]
  11. Bhattacharyya D. K., Lecomte M., Rieke C. J., Garavito M., Smith W. L. Involvement of arginine 120, glutamate 524, and tyrosine 355 in the binding of arachidonate and 2-phenylpropionic acid inhibitors to the cyclooxygenase active site of ovine prostaglandin endoperoxide H synthase-1. J Biol Chem. 1996 Jan 26;271(4):2179–2184. doi: 10.1074/jbc.271.4.2179. [DOI] [PubMed] [Google Scholar]
  12. Blackwell G. J., Flower R. J., Nijkamp F. P., Vane J. R. Phospholipase A2 activity of guinea-pig isolated perfused lungs: stimulation, and inhibition by anti-inflammatory steroids. Br J Pharmacol. 1978 Jan;62(1):79–89. doi: 10.1111/j.1476-5381.1978.tb07009.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Blanco A., Habib A., Levy-Toledano S., Maclouf J. Involvement of tyrosine kinases in the induction of cyclo-oxygenase-2 in human endothelial cells. Biochem J. 1995 Dec 1;312(Pt 2):419–423. doi: 10.1042/bj3120419. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Brennan P., O'Neill L. A. Effects of oxidants and antioxidants on nuclear factor kappa B activation in three different cell lines: evidence against a universal hypothesis involving oxygen radicals. Biochim Biophys Acta. 1995 Jan 25;1260(2):167–175. doi: 10.1016/0167-4781(94)00186-7. [DOI] [PubMed] [Google Scholar]
  15. Bry K. Epidermal growth factor and transforming growth factor-alpha enhance the interleukin-1- and tumor necrosis factor-stimulated prostaglandin E2 production and the interleukin-1 specific binding on amnion cells. Prostaglandins Leukot Essent Fatty Acids. 1993 Dec;49(6):923–928. doi: 10.1016/0952-3278(93)90177-x. [DOI] [PubMed] [Google Scholar]
  16. Bry K., Hallman M., Lappalainen U. Cytokines released by granulocytes and mononuclear cells stimulate amnion cell prostaglandin E2 production. Prostaglandins. 1994 Dec;48(6):389–399. doi: 10.1016/0090-6980(94)90005-1. [DOI] [PubMed] [Google Scholar]
  17. Böttcher I., Schweizer A., Glatt M., Werner H. A sulphonamido-indanone derivative CGP 28237 (ZK 34228), a novel non-steroidal anti-inflammatory agent without gastro-intestinal ulcerogenicity in rats. Drugs Exp Clin Res. 1987;13(5):237–245. [PubMed] [Google Scholar]
  18. Chan C. C., Boyce S., Brideau C., Ford-Hutchinson A. W., Gordon R., Guay D., Hill R. G., Li C. S., Mancini J., Penneton M. Pharmacology of a selective cyclooxygenase-2 inhibitor, L-745,337: a novel nonsteroidal anti-inflammatory agent with an ulcerogenic sparing effect in rat and nonhuman primate stomach. J Pharmacol Exp Ther. 1995 Sep;274(3):1531–1537. [PubMed] [Google Scholar]
  19. Chanmugam P., Feng L., Liou S., Jang B. C., Boudreau M., Yu G., Lee J. H., Kwon H. J., Beppu T., Yoshida M. Radicicol, a protein tyrosine kinase inhibitor, suppresses the expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide and in experimental glomerulonephritis. J Biol Chem. 1995 Mar 10;270(10):5418–5426. doi: 10.1074/jbc.270.10.5418. [DOI] [PubMed] [Google Scholar]
  20. Chepenik K. P., Diaz A., Jimenez S. A. Epidermal growth factor coordinately regulates the expression of prostaglandin G/H synthase and cytosolic phospholipase A2 genes in embryonic mouse cells. J Biol Chem. 1994 Aug 26;269(34):21786–21792. [PubMed] [Google Scholar]
  21. Chilton F. H., Fonteh A. N., Surette M. E., Triggiani M., Winkler J. D. Control of arachidonate levels within inflammatory cells. Biochim Biophys Acta. 1996 Jan 5;1299(1):1–15. doi: 10.1016/0005-2760(95)00169-7. [DOI] [PubMed] [Google Scholar]
  22. Clària J., Serhan C. N. Aspirin triggers previously undescribed bioactive eicosanoids by human endothelial cell-leukocyte interactions. Proc Natl Acad Sci U S A. 1995 Oct 10;92(21):9475–9479. doi: 10.1073/pnas.92.21.9475. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Copeland R. A., Williams J. M., Giannaras J., Nurnberg S., Covington M., Pinto D., Pick S., Trzaskos J. M. Mechanism of selective inhibition of the inducible isoform of prostaglandin G/H synthase. Proc Natl Acad Sci U S A. 1994 Nov 8;91(23):11202–11206. doi: 10.1073/pnas.91.23.11202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Crofford L. J., Wilder R. L., Ristimäki A. P., Sano H., Remmers E. F., Epps H. R., Hla T. Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids. J Clin Invest. 1994 Mar;93(3):1095–1101. doi: 10.1172/JCI117060. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Davidge S. T., Baker P. N., Laughlin M. K., Roberts J. M. Nitric oxide produced by endothelial cells increases production of eicosanoids through activation of prostaglandin H synthase. Circ Res. 1995 Aug;77(2):274–283. doi: 10.1161/01.res.77.2.274. [DOI] [PubMed] [Google Scholar]
  26. Dinchuk J. E., Car B. D., Focht R. J., Johnston J. J., Jaffee B. D., Covington M. B., Contel N. R., Eng V. M., Collins R. J., Czerniak P. M. Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature. 1995 Nov 23;378(6555):406–409. doi: 10.1038/378406a0. [DOI] [PubMed] [Google Scholar]
  27. Divers M. J., Lilford R. J., Miller D., Bulmer J. N. Cyclo-oxygenase distribution in human placenta and decidua does not change with labour after term or preterm delivery. Gynecol Obstet Invest. 1995;39(3):157–161. doi: 10.1159/000292400. [DOI] [PubMed] [Google Scholar]
  28. Doerfler M. E., Weiss J., Clark J. D., Elsbach P. Bacterial lipopolysaccharide primes human neutrophils for enhanced release of arachidonic acid and causes phosphorylation of an 85-kD cytosolic phospholipase A2. J Clin Invest. 1994 Apr;93(4):1583–1591. doi: 10.1172/JCI117138. [DOI] [PMC free article] [PubMed] [Google Scholar]
  29. DuBois R. N., Awad J., Morrow J., Roberts L. J., 2nd, Bishop P. R. Regulation of eicosanoid production and mitogenesis in rat intestinal epithelial cells by transforming growth factor-alpha and phorbol ester. J Clin Invest. 1994 Feb;93(2):493–498. doi: 10.1172/JCI116998. [DOI] [PMC free article] [PubMed] [Google Scholar]
  30. Eberhart C. E., Dubois R. N. Eicosanoids and the gastrointestinal tract. Gastroenterology. 1995 Jul;109(1):285–301. doi: 10.1016/0016-5085(95)90296-1. [DOI] [PubMed] [Google Scholar]
  31. Endo T., Ogushi F., Sone S., Ogura T., Taketani Y., Hayashi Y., Ueda N., Yamamoto S. Induction of cyclooxygenase-2 is responsible for interleukin-1 beta-dependent prostaglandin E2 synthesis by human lung fibroblasts. Am J Respir Cell Mol Biol. 1995 Mar;12(3):358–365. doi: 10.1165/ajrcmb.12.3.7873203. [DOI] [PubMed] [Google Scholar]
  32. Engelhardt G., Bögel R., Schnitzer C., Utzmann R. Meloxicam: influence on arachidonic acid metabolism. Part 1. In vitro findings. Biochem Pharmacol. 1996 Jan 12;51(1):21–28. doi: 10.1016/0006-2952(95)02111-6. [DOI] [PubMed] [Google Scholar]
  33. Engelhardt G., Homma D., Schlegel K., Utzmann R., Schnitzler C. Anti-inflammatory, analgesic, antipyretic and related properties of meloxicam, a new non-steroidal anti-inflammatory agent with favourable gastrointestinal tolerance. Inflamm Res. 1995 Oct;44(10):423–433. doi: 10.1007/BF01757699. [DOI] [PubMed] [Google Scholar]
  34. Feng L., Sun W., Xia Y., Tang W. W., Chanmugam P., Soyoola E., Wilson C. B., Hwang D. Cloning two isoforms of rat cyclooxygenase: differential regulation of their expression. Arch Biochem Biophys. 1993 Dec;307(2):361–368. doi: 10.1006/abbi.1993.1601. [DOI] [PubMed] [Google Scholar]
  35. Feng L., Xia Y., Garcia G. E., Hwang D., Wilson C. B. Involvement of reactive oxygen intermediates in cyclooxygenase-2 expression induced by interleukin-1, tumor necrosis factor-alpha, and lipopolysaccharide. J Clin Invest. 1995 Apr;95(4):1669–1675. doi: 10.1172/JCI117842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  36. Fletcher B. S., Kujubu D. A., Perrin D. M., Herschman H. R. Structure of the mitogen-inducible TIS10 gene and demonstration that the TIS10-encoded protein is a functional prostaglandin G/H synthase. J Biol Chem. 1992 Mar 5;267(7):4338–4344. [PubMed] [Google Scholar]
  37. Flower R. J. Eleventh Gaddum memorial lecture. Lipocortin and the mechanism of action of the glucocorticoids. Br J Pharmacol. 1988 Aug;94(4):987–1015. doi: 10.1111/j.1476-5381.1988.tb11614.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  38. Flower R. J., Rothwell N. J. Lipocortin-1: cellular mechanisms and clinical relevance. Trends Pharmacol Sci. 1994 Mar;15(3):71–76. doi: 10.1016/0165-6147(94)90281-x. [DOI] [PubMed] [Google Scholar]
  39. Flynn J. T., Hoff H., 3rd Lipopolysaccharide induces time-dependent increases in prostaglandin H synthase-2 and cytosolic phospholipase A2 mRNA in cultured human microvessel-derived endothelial cells. Shock. 1995 Dec;4(6):433–440. [PubMed] [Google Scholar]
  40. Forehand J. R., Johnston R. B., Jr, Bomalaski J. S. Phospholipase A2 activity in human neutrophils. Stimulation by lipopolysaccharide and possible involvement in priming for an enhanced respiratory burst. J Immunol. 1993 Nov 1;151(9):4918–4925. [PubMed] [Google Scholar]
  41. Forman B. M., Tontonoz P., Chen J., Brun R. P., Spiegelman B. M., Evans R. M. 15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gamma. Cell. 1995 Dec 1;83(5):803–812. doi: 10.1016/0092-8674(95)90193-0. [DOI] [PubMed] [Google Scholar]
  42. Freed K. A., Aitken M. A., Brennecke S. P., Rice G. E. Prostaglandin G/H synthase-1 messenger RNA relative abundance in human amnion, choriodecidua and placenta before, during and after spontaneous-onset labour at term. Gynecol Obstet Invest. 1995;39(2):73–78. doi: 10.1159/000292383. [DOI] [PubMed] [Google Scholar]
  43. Fukushima M. Biological activities and mechanisms of action of PGJ2 and related compounds: an update. Prostaglandins Leukot Essent Fatty Acids. 1992 Sep;47(1):1–12. doi: 10.1016/0952-3278(92)90178-l. [DOI] [PubMed] [Google Scholar]
  44. Futaki N., Takahashi S., Yokoyama M., Arai I., Higuchi S., Otomo S. NS-398, a new anti-inflammatory agent, selectively inhibits prostaglandin G/H synthase/cyclooxygenase (COX-2) activity in vitro. Prostaglandins. 1994 Jan;47(1):55–59. doi: 10.1016/0090-6980(94)90074-4. [DOI] [PubMed] [Google Scholar]
  45. Futaki N., Yoshikawa K., Hamasaka Y., Arai I., Higuchi S., Iizuka H., Otomo S. NS-398, a novel non-steroidal anti-inflammatory drug with potent analgesic and antipyretic effects, which causes minimal stomach lesions. Gen Pharmacol. 1993 Jan;24(1):105–110. doi: 10.1016/0306-3623(93)90018-s. [DOI] [PubMed] [Google Scholar]
  46. Gans K. R., Galbraith W., Roman R. J., Haber S. B., Kerr J. S., Schmidt W. K., Smith C., Hewes W. E., Ackerman N. R. Anti-inflammatory and safety profile of DuP 697, a novel orally effective prostaglandin synthesis inhibitor. J Pharmacol Exp Ther. 1990 Jul;254(1):180–187. [PubMed] [Google Scholar]
  47. Gierse J. K., Hauser S. D., Creely D. P., Koboldt C., Rangwala S. H., Isakson P. C., Seibert K. Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase. Biochem J. 1995 Jan 15;305(Pt 2):479–484. doi: 10.1042/bj3050479. [DOI] [PMC free article] [PubMed] [Google Scholar]
  48. Gierse J. K., McDonald J. J., Hauser S. D., Rangwala S. H., Koboldt C. M., Seibert K. A single amino acid difference between cyclooxygenase-1 (COX-1) and -2 (COX-2) reverses the selectivity of COX-2 specific inhibitors. J Biol Chem. 1996 Jun 28;271(26):15810–15814. doi: 10.1074/jbc.271.26.15810. [DOI] [PubMed] [Google Scholar]
  49. Gilbert R. S., Reddy S. T., Kujubu D. A., Xie W., Luner S., Herschman H. R. Transforming growth factor beta 1 augments mitogen-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene both in Swiss 3T3 cells and in murine embryo fibroblasts. J Cell Physiol. 1994 Apr;159(1):67–75. doi: 10.1002/jcp.1041590110. [DOI] [PubMed] [Google Scholar]
  50. Giovannucci E., Egan K. M., Hunter D. J., Stampfer M. J., Colditz G. A., Willett W. C., Speizer F. E. Aspirin and the risk of colorectal cancer in women. N Engl J Med. 1995 Sep 7;333(10):609–614. doi: 10.1056/NEJM199509073331001. [DOI] [PubMed] [Google Scholar]
  51. Glaser K. B., Sung A., Bauer J., Weichman B. M. Regulation of eicosanoid biosynthesis in the macrophage. Involvement of protein tyrosine phosphorylation and modulation by selective protein tyrosine kinase inhibitors. Biochem Pharmacol. 1993 Feb 9;45(3):711–721. doi: 10.1016/0006-2952(93)90147-o. [DOI] [PubMed] [Google Scholar]
  52. Goldblum S. E., Brann T. W., Ding X., Pugin J., Tobias P. S. Lipopolysaccharide (LPS)-binding protein and soluble CD14 function as accessory molecules for LPS-induced changes in endothelial barrier function, in vitro. J Clin Invest. 1994 Feb;93(2):692–702. doi: 10.1172/JCI117022. [DOI] [PMC free article] [PubMed] [Google Scholar]
  53. Goppelt-Struebe M. Regulation of prostaglandin endoperoxide synthase (cyclooxygenase) isozyme expression. Prostaglandins Leukot Essent Fatty Acids. 1995 Apr;52(4):213–222. doi: 10.1016/0952-3278(95)90039-x. [DOI] [PubMed] [Google Scholar]
  54. Grossman C. J., Wiseman J., Lucas F. S., Trevethick M. A., Birch P. J. Inhibition of constitutive and inducible cyclooxygenase activity in human platelets and mononuclear cells by NSAIDs and Cox 2 inhibitors. Inflamm Res. 1995 Jun;44(6):253–257. doi: 10.1007/BF01782978. [DOI] [PubMed] [Google Scholar]
  55. Gu W., Rice G. E., Brennecke S. P. Effects of lipopolysaccharide on human placental prostaglandin F2 alpha production in vitro. Prostaglandins Leukot Essent Fatty Acids. 1994 Jun;50(6):311–315. doi: 10.1016/0952-3278(94)90239-9. [DOI] [PubMed] [Google Scholar]
  56. Guo Q., Wang L. H., Ruan K. H., Kulmacz R. J. Role of Val509 in time-dependent inhibition of human prostaglandin H synthase-2 cyclooxygenase activity by isoform-selective agents. J Biol Chem. 1996 Aug 9;271(32):19134–19139. doi: 10.1074/jbc.271.32.19134. [DOI] [PubMed] [Google Scholar]
  57. Hamasaki Y., Eling T. E. EGF and TPA stimulate de novo synthesis of PGHS-1 and PGHS-2 through different signal transduction pathways. Prostaglandins Leukot Essent Fatty Acids. 1995 Sep;53(3):225–229. doi: 10.1016/0952-3278(95)90121-3. [DOI] [PubMed] [Google Scholar]
  58. Hamasaki Y., Kitzler J., Hardman R., Nettesheim P., Eling T. E. Phorbol ester and epidermal growth factor enhance the expression of two inducible prostaglandin H synthase genes in rat tracheal epithelial cells. Arch Biochem Biophys. 1993 Jul;304(1):226–234. doi: 10.1006/abbi.1993.1343. [DOI] [PubMed] [Google Scholar]
  59. Hamberg M., Svensson J., Wakabayashi T., Samuelsson B. Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc Natl Acad Sci U S A. 1974 Feb;71(2):345–349. doi: 10.1073/pnas.71.2.345. [DOI] [PMC free article] [PubMed] [Google Scholar]
  60. Harada Y., Hatanaka K., Kawamura M., Saito M., Ogino M., Majima M., Ohno T., Ogino K., Yamamoto K., Taketani Y. Role of prostaglandin H synthase-2 in prostaglandin E2 formation in rat carrageenin-induced pleurisy. Prostaglandins. 1996 Jan;51(1):19–33. doi: 10.1016/0090-6980(95)00168-9. [DOI] [PubMed] [Google Scholar]
  61. Harrison J. R., Lorenzo J. A., Kawaguchi H., Raisz L. G., Pilbeam C. Stimulation of prostaglandin E2 production by interleukin-1 alpha and transforming growth factor alpha in osteoblastic MC3T3-E1 cells. J Bone Miner Res. 1994 Jun;9(6):817–823. doi: 10.1002/jbmr.5650090607. [DOI] [PubMed] [Google Scholar]
  62. Haynes D. R., Whitehouse M. W., Vernon-Roberts B. The prostaglandin E1 analogue, misoprostol, regulates inflammatory cytokines and immune functions in vitro like the natural prostaglandins E1, E2 and E3. Immunology. 1992 Jun;76(2):251–257. [PMC free article] [PubMed] [Google Scholar]
  63. Hempel S. L., Monick M. M., He B., Yano T., Hunninghake G. W. Synthesis of prostaglandin H synthase-2 by human alveolar macrophages in response to lipopolysaccharide is inhibited by decreased cell oxidant tone. J Biol Chem. 1994 Dec 30;269(52):32979–32984. [PubMed] [Google Scholar]
  64. Hempel S. L., Monick M. M., Hunninghake G. W. Lipopolysaccharide induces prostaglandin H synthase-2 protein and mRNA in human alveolar macrophages and blood monocytes. J Clin Invest. 1994 Jan;93(1):391–396. doi: 10.1172/JCI116971. [DOI] [PMC free article] [PubMed] [Google Scholar]
  65. Herschman H. R. Primary response genes induced by growth factors and tumor promoters. Annu Rev Biochem. 1991;60:281–319. doi: 10.1146/annurev.bi.60.070191.001433. [DOI] [PubMed] [Google Scholar]
  66. Herschman H. R. Prostaglandin synthase 2. Biochim Biophys Acta. 1996 Jan 5;1299(1):125–140. doi: 10.1016/0005-2760(95)00194-8. [DOI] [PubMed] [Google Scholar]
  67. Hirokawa K., O'Shaughnessy K., Moore K., Ramrakha P., Wilkins M. R. Induction of nitric oxide synthase in cultured vascular smooth muscle cells: the role of cyclic AMP. Br J Pharmacol. 1994 Jun;112(2):396–402. doi: 10.1111/j.1476-5381.1994.tb13085.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  68. Hirst J. J., Teixeira F. J., Zakar T., Olson D. M. Prostaglandin endoperoxide-H synthase-1 and -2 messenger ribonucleic acid levels in human amnion with spontaneous labor onset. J Clin Endocrinol Metab. 1995 Feb;80(2):517–523. doi: 10.1210/jcem.80.2.7852513. [DOI] [PubMed] [Google Scholar]
  69. Hla T., Neilson K. Human cyclooxygenase-2 cDNA. Proc Natl Acad Sci U S A. 1992 Aug 15;89(16):7384–7388. doi: 10.1073/pnas.89.16.7384. [DOI] [PMC free article] [PubMed] [Google Scholar]
  70. Hsi L. C., Hoganson C. W., Babcock G. T., Garavito R. M., Smith W. L. An examination of the source of the tyrosyl radical in ovine prostaglandin endoperoxide synthase-1. Biochem Biophys Res Commun. 1995 Feb 15;207(2):652–660. doi: 10.1006/bbrc.1995.1237. [DOI] [PubMed] [Google Scholar]
  71. Hulkower K. I., Wertheimer S. J., Levin W., Coffey J. W., Anderson C. M., Chen T., DeWitt D. L., Crowl R. M., Hope W. C., Morgan D. W. Interleukin-1 beta induces cytosolic phospholipase A2 and prostaglandin H synthase in rheumatoid synovial fibroblasts. Evidence for their roles in the production of prostaglandin E2. Arthritis Rheum. 1994 May;37(5):653–661. doi: 10.1002/art.1780370508. [DOI] [PubMed] [Google Scholar]
  72. Huskisson E. C., Berry H., Gishen P., Jubb R. W., Whitehead J. Effects of antiinflammatory drugs on the progression of osteoarthritis of the knee. LINK Study Group. Longitudinal Investigation of Nonsteroidal Antiinflammatory Drugs in Knee Osteoarthritis. J Rheumatol. 1995 Oct;22(10):1941–1946. [PubMed] [Google Scholar]
  73. Imai T., Hirata Y., Kanno K., Marumo F. Induction of nitric oxide synthase by cyclic AMP in rat vascular smooth muscle cells. J Clin Invest. 1994 Feb;93(2):543–549. doi: 10.1172/JCI117005. [DOI] [PMC free article] [PubMed] [Google Scholar]
  74. Inoue H., Nanayama T., Hara S., Yokoyama C., Tanabe T. The cyclic AMP response element plays an essential role in the expression of the human prostaglandin-endoperoxide synthase 2 gene in differentiated U937 monocytic cells. FEBS Lett. 1994 Aug 15;350(1):51–54. doi: 10.1016/0014-5793(94)00731-4. [DOI] [PubMed] [Google Scholar]
  75. Inoue H., Yokoyama C., Hara S., Tone Y., Tanabe T. Transcriptional regulation of human prostaglandin-endoperoxide synthase-2 gene by lipopolysaccharide and phorbol ester in vascular endothelial cells. Involvement of both nuclear factor for interleukin-6 expression site and cAMP response element. J Biol Chem. 1995 Oct 20;270(42):24965–24971. doi: 10.1074/jbc.270.42.24965. [DOI] [PubMed] [Google Scholar]
  76. Irvine R. F. How is the level of free arachidonic acid controlled in mammalian cells? Biochem J. 1982 Apr 15;204(1):3–16. doi: 10.1042/bj2040003. [DOI] [PMC free article] [PubMed] [Google Scholar]
  77. Ishihara O., Matsuoka K., Kinoshita K., Sullivan M. H., Elder M. G. Interleukin-1 beta-stimulated PGE2 production from early first trimester human decidual cells is inhibited by dexamethasone and progesterone. Prostaglandins. 1995 Jan;49(1):15–26. doi: 10.1016/0090-6980(94)00009-l. [DOI] [PubMed] [Google Scholar]
  78. Jackson B. A., Goldstein R. H., Roy R., Cozzani M., Taylor L., Polgar P. Effects of transforming growth factor beta and interleukin-1 beta on expression of cyclooxygenase 1 and 2 and phospholipase A2 mRNA in lung fibroblasts and endothelial cells in culture. Biochem Biophys Res Commun. 1993 Dec 30;197(3):1465–1474. doi: 10.1006/bbrc.1993.2642. [DOI] [PubMed] [Google Scholar]
  79. Johnson R. D., Walsh S. W., Everson W. V., Nelson D. M. Differentiation and growth on a fibrin matrix modulate the cyclooxygenase expression and thromboxane production by cultured human placental trophoblasts. Prostaglandins Leukot Essent Fatty Acids. 1995 Jan;52(1):21–27. doi: 10.1016/0952-3278(95)90092-6. [DOI] [PubMed] [Google Scholar]
  80. Kargman S. L., O'Neill G. P., Vickers P. J., Evans J. F., Mancini J. A., Jothy S. Expression of prostaglandin G/H synthase-1 and -2 protein in human colon cancer. Cancer Res. 1995 Jun 15;55(12):2556–2559. [PubMed] [Google Scholar]
  81. Karim S., Habib A., Lévy-Toledano S., Maclouf J. Cyclooxygenase-1 and -2 of endothelial cells utilize exogenous or endogenous arachidonic acid for transcellular production of thromboxane. J Biol Chem. 1996 May 17;271(20):12042–12048. doi: 10.1074/jbc.271.20.12042. [DOI] [PubMed] [Google Scholar]
  82. Katori M., Harada Y., Hatanaka K., Majima M., Kawamura M., Ohno T., Aizawa A., Yamamoto S. Induction of prostaglandin H synthase-2 in rat carrageenin-induced pleurisy and effect of a selective COX-2 inhibitor. Adv Prostaglandin Thromboxane Leukot Res. 1995;23:345–347. [PubMed] [Google Scholar]
  83. Kawaguchi H., Pilbeam C. C., Gronowicz G., Abreu C., Fletcher B. S., Herschman H. R., Raisz L. G., Hurley M. M. Transcriptional induction of prostaglandin G/H synthase-2 by basic fibroblast growth factor. J Clin Invest. 1995 Aug;96(2):923–930. doi: 10.1172/JCI118140. [DOI] [PMC free article] [PubMed] [Google Scholar]
  84. Kawaguchi H., Raisz L. G., Voznesensky O. S., Alander C. B., Hakeda Y., Pilbeam C. C. Regulation of the two prostaglandin G/H synthases by parathyroid hormone, interleukin-1, cortisol, and prostaglandin E2 in cultured neonatal mouse calvariae. Endocrinology. 1994 Sep;135(3):1157–1164. doi: 10.1210/endo.135.3.8070358. [DOI] [PubMed] [Google Scholar]
  85. Kelner M. J., Uglik S. F. Mechanism of prostaglandin E2 release and increase in PGH2/PGE2 isomerase activity by PDGF: involvement of nitric oxide. Arch Biochem Biophys. 1994 Jul;312(1):240–243. doi: 10.1006/abbi.1994.1305. [DOI] [PubMed] [Google Scholar]
  86. Kennard E. A., Zimmerman P. D., Friedman C. I., Kniss D. A. Interleukin-1 beta induces cyclooxygenase-2 in cultured human decidual cells. Am J Reprod Immunol. 1995 Aug;34(2):65–71. doi: 10.1111/j.1600-0897.1995.tb00920.x. [DOI] [PubMed] [Google Scholar]
  87. Kennedy T. A., Smith C. J., Marnett L. J. Investigation of the role of cysteines in catalysis by prostaglandin endoperoxide synthase. J Biol Chem. 1994 Nov 4;269(44):27357–27364. [PubMed] [Google Scholar]
  88. Kester M., Coroneos E., Thomas P. J., Dunn M. J. Endothelin stimulates prostaglandin endoperoxide synthase-2 mRNA expression and protein synthesis through a tyrosine kinase-signaling pathway in rat mesangial cells. J Biol Chem. 1994 Sep 9;269(36):22574–22580. [PubMed] [Google Scholar]
  89. Klein T., Nüsing R. M., Pfeilschifter J., Ullrich V. Selective inhibition of cyclooxygenase 2. Biochem Pharmacol. 1994 Oct 18;48(8):1605–1610. doi: 10.1016/0006-2952(94)90205-4. [DOI] [PubMed] [Google Scholar]
  90. Klein T., Nüsing R. M., Wiesenberg-Boettcher I., Ullrich V. Mechanistic studies on the selective inhibition of cyclooxygenase-2 by indanone derivatives. Biochem Pharmacol. 1996 Feb 9;51(3):285–290. doi: 10.1016/0006-2952(95)02170-1. [DOI] [PubMed] [Google Scholar]
  91. Kliewer S. A., Lenhard J. M., Willson T. M., Patel I., Morris D. C., Lehmann J. M. A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor gamma and promotes adipocyte differentiation. Cell. 1995 Dec 1;83(5):813–819. doi: 10.1016/0092-8674(95)90194-9. [DOI] [PubMed] [Google Scholar]
  92. Knott I., Dieu M., Burton M., Houbion A., Remacle J., Raes M. Induction of cyclooxygenase by interleukin 1: comparative study between human synovial cells and chondrocytes. J Rheumatol. 1994 Mar;21(3):462–466. [PubMed] [Google Scholar]
  93. Koizumi T., Odani N., Okuyama T., Ichikawa A., Negishi M. Identification of a cis-regulatory element for delta 12-prostaglandin J2-induced expression of the rat heme oxygenase gene. J Biol Chem. 1995 Sep 15;270(37):21779–21784. doi: 10.1074/jbc.270.37.21779. [DOI] [PubMed] [Google Scholar]
  94. Kosaka T., Miyata A., Ihara H., Hara S., Sugimoto T., Takeda O., Takahashi E., Tanabe T. Characterization of the human gene (PTGS2) encoding prostaglandin-endoperoxide synthase 2. Eur J Biochem. 1994 May 1;221(3):889–897. doi: 10.1111/j.1432-1033.1994.tb18804.x. [DOI] [PubMed] [Google Scholar]
  95. Kujubu D. A., Herschman H. R. Dexamethasone inhibits mitogen induction of the TIS10 prostaglandin synthase/cyclooxygenase gene. J Biol Chem. 1992 Apr 25;267(12):7991–7994. [PubMed] [Google Scholar]
  96. Kulmacz R. J., Pendleton R. B., Lands W. E. Interaction between peroxidase and cyclooxygenase activities in prostaglandin-endoperoxide synthase. Interpretation of reaction kinetics. J Biol Chem. 1994 Feb 25;269(8):5527–5536. [PubMed] [Google Scholar]
  97. Kurtz E. S., Bailey S. C., Arshad F., Lee A. A., Przekop P. A. Leflunomide: an active antiinflammatory and antiproliferative agent in models of dermatologic disease. Inflamm Res. 1995 Aug;44 (Suppl 2):S187–S188. doi: 10.1007/BF01778324. [DOI] [PubMed] [Google Scholar]
  98. Laneuville O., Breuer D. K., Dewitt D. L., Hla T., Funk C. D., Smith W. L. Differential inhibition of human prostaglandin endoperoxide H synthases-1 and -2 by nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 1994 Nov;271(2):927–934. [PubMed] [Google Scholar]
  99. Langenbach R., Morham S. G., Tiano H. F., Loftin C. D., Ghanayem B. I., Chulada P. C., Mahler J. F., Lee C. A., Goulding E. H., Kluckman K. D. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 1995 Nov 3;83(3):483–492. doi: 10.1016/0092-8674(95)90126-4. [DOI] [PubMed] [Google Scholar]
  100. Langman M. J., Weil J., Wainwright P., Lawson D. H., Rawlins M. D., Logan R. F., Murphy M., Vessey M. P., Colin-Jones D. G. Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet. 1994 Apr 30;343(8905):1075–1078. doi: 10.1016/s0140-6736(94)90185-6. [DOI] [PubMed] [Google Scholar]
  101. Lecomte M., Laneuville O., Ji C., DeWitt D. L., Smith W. L. Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin. J Biol Chem. 1994 May 6;269(18):13207–13215. [PubMed] [Google Scholar]
  102. Lee S. H., Soyoola E., Chanmugam P., Hart S., Sun W., Zhong H., Liou S., Simmons D., Hwang D. Selective expression of mitogen-inducible cyclooxygenase in macrophages stimulated with lipopolysaccharide. J Biol Chem. 1992 Dec 25;267(36):25934–25938. [PubMed] [Google Scholar]
  103. Loll P. J., Picot D., Garavito R. M. The structural basis of aspirin activity inferred from the crystal structure of inactivated prostaglandin H2 synthase. Nat Struct Biol. 1995 Aug;2(8):637–643. doi: 10.1038/nsb0895-637. [DOI] [PubMed] [Google Scholar]
  104. Lu X., Xie W., Reed D., Bradshaw W. S., Simmons D. L. Nonsteroidal antiinflammatory drugs cause apoptosis and induce cyclooxygenases in chicken embryo fibroblasts. Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7961–7965. doi: 10.1073/pnas.92.17.7961. [DOI] [PMC free article] [PubMed] [Google Scholar]
  105. Mancini J. A., O'Neill G. P., Bayly C., Vickers P. J. Mutation of serine-516 in human prostaglandin G/H synthase-2 to methionine or aspirin acetylation of this residue stimulates 15-R-HETE synthesis. FEBS Lett. 1994 Mar 28;342(1):33–37. doi: 10.1016/0014-5793(94)80579-2. [DOI] [PubMed] [Google Scholar]
  106. Mancini J. A., Riendeau D., Falgueyret J. P., Vickers P. J., O'Neill G. P. Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety. J Biol Chem. 1995 Dec 8;270(49):29372–29377. doi: 10.1074/jbc.270.49.29372. [DOI] [PubMed] [Google Scholar]
  107. Mangelsdorf D. J., Evans R. M. The RXR heterodimers and orphan receptors. Cell. 1995 Dec 15;83(6):841–850. doi: 10.1016/0092-8674(95)90200-7. [DOI] [PubMed] [Google Scholar]
  108. Matijevic-Aleksic N., Sanduja S. K., Wang L. H., Wu K. K. Differential expression of thromboxane A synthase and prostaglandin H synthase in megakaryocytic cell line. Biochim Biophys Acta. 1995 Nov 9;1269(2):167–175. doi: 10.1016/0167-4889(95)00116-a. [DOI] [PubMed] [Google Scholar]
  109. Mattar T., Kochhar K., Bartlett R., Bremer E. G., Finnegan A. Inhibition of the epidermal growth factor receptor tyrosine kinase activity by leflunomide. FEBS Lett. 1993 Nov 15;334(2):161–164. doi: 10.1016/0014-5793(93)81704-4. [DOI] [PubMed] [Google Scholar]
  110. Mertz P. M., DeWitt D. L., Stetler-Stevenson W. G., Wahl L. M. Interleukin 10 suppression of monocyte prostaglandin H synthase-2. Mechanism of inhibition of prostaglandin-dependent matrix metalloproteinase production. J Biol Chem. 1994 Aug 19;269(33):21322–21329. [PubMed] [Google Scholar]
  111. Mitchell J. A., Akarasereenont P., Thiemermann C., Flower R. J., Vane J. R. Selectivity of nonsteroidal antiinflammatory drugs as inhibitors of constitutive and inducible cyclooxygenase. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11693–11697. doi: 10.1073/pnas.90.24.11693. [DOI] [PMC free article] [PubMed] [Google Scholar]
  112. Mitchell J. A., Belvisi M. G., Akarasereenont P., Robbins R. A., Kwon O. J., Croxtall J., Barnes P. J., Vane J. R. Induction of cyclo-oxygenase-2 by cytokines in human pulmonary epithelial cells: regulation by dexamethasone. Br J Pharmacol. 1994 Nov;113(3):1008–1014. doi: 10.1111/j.1476-5381.1994.tb17093.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  113. Miyata A., Hara S., Yokoyama C., Inoue H., Ullrich V., Tanabe T. Molecular cloning and expression of human prostacyclin synthase. Biochem Biophys Res Commun. 1994 May 16;200(3):1728–1734. doi: 10.1006/bbrc.1994.1652. [DOI] [PubMed] [Google Scholar]
  114. Miyata A., Yokoyama C., Ihara H., Bandoh S., Takeda O., Takahashi E., Tanabe T. Characterization of the human gene (TBXAS1) encoding thromboxane synthase. Eur J Biochem. 1994 Sep 1;224(2):273–279. doi: 10.1111/j.1432-1033.1994.00273.x. [DOI] [PubMed] [Google Scholar]
  115. Mohr C., Davis G. S., Graebner C., Hemenway D. R., Gemsa D. Enhanced release of prostaglandin E2 from macrophages of rats with silicosis. Am J Respir Cell Mol Biol. 1992 Apr;6(4):390–396. doi: 10.1165/ajrcmb/6.4.390. [DOI] [PubMed] [Google Scholar]
  116. Moncada S., Gryglewski R., Bunting S., Vane J. R. An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet aggregation. Nature. 1976 Oct 21;263(5579):663–665. doi: 10.1038/263663a0. [DOI] [PubMed] [Google Scholar]
  117. Moon C. K., Lee S. H., Kim J. Y., Kim M. J., Lee J. Y., Moon C. H. Staurosporine induces de novo synthesis of prostaglandin H synthase-2 in rat alveolar macrophages. Life Sci. 1995;57(6):571–578. doi: 10.1016/0024-3205(95)00307-r. [DOI] [PubMed] [Google Scholar]
  118. Moore K. W., O'Garra A., de Waal Malefyt R., Vieira P., Mosmann T. R. Interleukin-10. Annu Rev Immunol. 1993;11:165–190. doi: 10.1146/annurev.iy.11.040193.001121. [DOI] [PubMed] [Google Scholar]
  119. Morham S. G., Langenbach R., Loftin C. D., Tiano H. F., Vouloumanos N., Jennette J. C., Mahler J. F., Kluckman K. D., Ledford A., Lee C. A. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 1995 Nov 3;83(3):473–482. doi: 10.1016/0092-8674(95)90125-6. [DOI] [PubMed] [Google Scholar]
  120. Morita I., Schindler M., Regier M. K., Otto J. C., Hori T., DeWitt D. L., Smith W. L. Different intracellular locations for prostaglandin endoperoxide H synthase-1 and -2. J Biol Chem. 1995 May 5;270(18):10902–10908. doi: 10.1074/jbc.270.18.10902. [DOI] [PubMed] [Google Scholar]
  121. Morris J. K., Richards J. S. Luteinizing hormone induces prostaglandin endoperoxide synthase-2 and luteinization in vitro by A-kinase and C-kinase pathways. Endocrinology. 1995 Apr;136(4):1549–1558. doi: 10.1210/endo.136.4.7895665. [DOI] [PubMed] [Google Scholar]
  122. Murakami M., Austen K. F., Arm J. P. The immediate phase of c-kit ligand stimulation of mouse bone marrow-derived mast cells elicits rapid leukotriene C4 generation through posttranslational activation of cytosolic phospholipase A2 and 5-lipoxygenase. J Exp Med. 1995 Jul 1;182(1):197–206. doi: 10.1084/jem.182.1.197. [DOI] [PMC free article] [PubMed] [Google Scholar]
  123. Murakami M., Matsumoto R., Austen K. F., Arm J. P. Prostaglandin endoperoxide synthase-1 and -2 couple to different transmembrane stimuli to generate prostaglandin D2 in mouse bone marrow-derived mast cells. J Biol Chem. 1994 Sep 2;269(35):22269–22275. [PubMed] [Google Scholar]
  124. Murakami M., Penrose J. F., Urade Y., Austen K. F., Arm J. P. Interleukin 4 suppresses c-kit ligand-induced expression of cytosolic phospholipase A2 and prostaglandin endoperoxide synthase 2 and their roles in separate pathways of eicosanoid synthesis in mouse bone marrow-derived mast cells. Proc Natl Acad Sci U S A. 1995 Jun 20;92(13):6107–6111. doi: 10.1073/pnas.92.13.6107. [DOI] [PMC free article] [PubMed] [Google Scholar]
  125. Müller-Decker K., Scholz K., Marks F., Fürstenberger G. Differential expression of prostaglandin H synthase isozymes during multistage carcinogenesis in mouse epidermis. Mol Carcinog. 1995 Jan;12(1):31–41. doi: 10.1002/mc.2940120106. [DOI] [PubMed] [Google Scholar]
  126. Nanayama T., Hara S., Inoue H., Yokoyama C., Tanabe T. Regulation of two isozymes of prostaglandin endoperoxide synthase and thromboxane synthase in human monoblastoid cell line U937. Prostaglandins. 1995 Jun;49(6):371–382. doi: 10.1016/0090-6980(95)00068-l. [DOI] [PubMed] [Google Scholar]
  127. Negishi M., Koizumi T., Ichikawa A. Biological actions of delta 12-prostaglandin J2. J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):443–448. doi: 10.1016/0929-7855(95)00029-p. [DOI] [PubMed] [Google Scholar]
  128. Negishi M., Odani N., Koizumi T., Takahashi S., Ichikawa A. Involvement of protein kinase in delta 12-prostaglandin J2-induced expression of rat heme oxygenase-1 gene. FEBS Lett. 1995 Sep 25;372(2-3):279–282. doi: 10.1016/0014-5793(95)01001-u. [DOI] [PubMed] [Google Scholar]
  129. Niiro H., Otsuka T., Tanabe T., Hara S., Kuga S., Nemoto Y., Tanaka Y., Nakashima H., Kitajima S., Abe M. Inhibition by interleukin-10 of inducible cyclooxygenase expression in lipopolysaccharide-stimulated monocytes: its underlying mechanism in comparison with interleukin-4. Blood. 1995 Jun 15;85(12):3736–3745. [PubMed] [Google Scholar]
  130. Nüsing R., Ullrich V. Regulation of cyclooxygenase and thromboxane synthase in human monocytes. Eur J Biochem. 1992 May 15;206(1):131–136. doi: 10.1111/j.1432-1033.1992.tb16910.x. [DOI] [PubMed] [Google Scholar]
  131. O'Banion M. K., Winn V. D., Young D. A. cDNA cloning and functional activity of a glucocorticoid-regulated inflammatory cyclooxygenase. Proc Natl Acad Sci U S A. 1992 Jun 1;89(11):4888–4892. doi: 10.1073/pnas.89.11.4888. [DOI] [PMC free article] [PubMed] [Google Scholar]
  132. O'Neill G. P., Mancini J. A., Kargman S., Yergey J., Kwan M. Y., Falgueyret J. P., Abramovitz M., Kennedy B. P., Ouellet M., Cromlish W. Overexpression of human prostaglandin G/H synthase-1 and -2 by recombinant vaccinia virus: inhibition by nonsteroidal anti-inflammatory drugs and biosynthesis of 15-hydroxyeicosatetraenoic acid. Mol Pharmacol. 1994 Feb;45(2):245–254. [PubMed] [Google Scholar]
  133. Otto J. C., Smith W. L. Prostaglandin endoperoxide synthases-1 and -2. J Lipid Mediat Cell Signal. 1995 Oct;12(2-3):139–156. doi: 10.1016/0929-7855(95)00015-i. [DOI] [PubMed] [Google Scholar]
  134. Otto J. C., Smith W. L. The orientation of prostaglandin endoperoxide synthases-1 and -2 in the endoplasmic reticulum. J Biol Chem. 1994 Aug 5;269(31):19868–19875. [PubMed] [Google Scholar]
  135. Ouellet M., Percival M. D. Effect of inhibitor time-dependency on selectivity towards cyclooxygenase isoforms. Biochem J. 1995 Feb 15;306(Pt 1):247–251. doi: 10.1042/bj3060247. [DOI] [PMC free article] [PubMed] [Google Scholar]
  136. Percival M. D., Ouellet M., Vincent C. J., Yergey J. A., Kennedy B. P., O'Neill G. P. Purification and characterization of recombinant human cyclooxygenase-2. Arch Biochem Biophys. 1994 Nov 15;315(1):111–118. doi: 10.1006/abbi.1994.1478. [DOI] [PubMed] [Google Scholar]
  137. Picot D., Loll P. J., Garavito R. M. The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1. Nature. 1994 Jan 20;367(6460):243–249. doi: 10.1038/367243a0. [DOI] [PubMed] [Google Scholar]
  138. Pilbeam C. C., Raisz L. G., Voznesensky O., Alander C. B., Delman B. N., Kawaguchi H. Autoregulation of inducible prostaglandin G/H synthase in osteoblastic cells by prostaglandins. J Bone Miner Res. 1995 Mar;10(3):406–414. doi: 10.1002/jbmr.5650100311. [DOI] [PubMed] [Google Scholar]
  139. Pugin J., Schürer-Maly C. C., Leturcq D., Moriarty A., Ulevitch R. J., Tobias P. S. Lipopolysaccharide activation of human endothelial and epithelial cells is mediated by lipopolysaccharide-binding protein and soluble CD14. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2744–2748. doi: 10.1073/pnas.90.7.2744. [DOI] [PMC free article] [PubMed] [Google Scholar]
  140. Reddy S. T., Gilbert R. S., Xie W., Luner S., Herschman H. R. TGF-beta 1 inhibits both endotoxin-induced prostaglandin synthesis and expression of the TIS10/prostaglandin synthase 2 gene in murine macrophages. J Leukoc Biol. 1994 Feb;55(2):192–200. doi: 10.1002/jlb.55.2.192. [DOI] [PubMed] [Google Scholar]
  141. Reddy S. T., Herschman H. R. Ligand-induced prostaglandin synthesis requires expression of the TIS10/PGS-2 prostaglandin synthase gene in murine fibroblasts and macrophages. J Biol Chem. 1994 Jun 3;269(22):15473–15480. [PubMed] [Google Scholar]
  142. Reiger M. K., DeWitt D. L., Schindler M. S., Smith W. L. Subcellular localization of prostaglandin endoperoxide synthase-2 in murine 3T3 cells. Arch Biochem Biophys. 1993 Mar;301(2):439–444. doi: 10.1006/abbi.1993.1168. [DOI] [PubMed] [Google Scholar]
  143. Reitz D. B., Li J. J., Norton M. B., Reinhard E. J., Collins J. T., Anderson G. D., Gregory S. A., Koboldt C. M., Perkins W. E., Seibert K. Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors. J Med Chem. 1994 Nov 11;37(23):3878–3881. doi: 10.1021/jm00049a005. [DOI] [PubMed] [Google Scholar]
  144. Ren Y., Loose-Mitchell D. S., Kulmacz R. J. Prostaglandin H synthase-1: evaluation of C-terminus function. Arch Biochem Biophys. 1995 Feb 1;316(2):751–757. doi: 10.1006/abbi.1995.1100. [DOI] [PubMed] [Google Scholar]
  145. Ren Y., Walker C., Loose-Mitchell D. S., Deng J., Ruan K. H., Kulmacz R. J. Topology of prostaglandin H synthase-1 in the endoplasmic reticulum membrane. Arch Biochem Biophys. 1995 Oct 20;323(1):205–214. doi: 10.1006/abbi.1995.0027. [DOI] [PubMed] [Google Scholar]
  146. Renz H., Gong J. H., Schmidt A., Nain M., Gemsa D. Release of tumor necrosis factor-alpha from macrophages. Enhancement and suppression are dose-dependently regulated by prostaglandin E2 and cyclic nucleotides. J Immunol. 1988 Oct 1;141(7):2388–2393. [PubMed] [Google Scholar]
  147. Ristimäki A., Garfinkel S., Wessendorf J., Maciag T., Hla T. Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation. J Biol Chem. 1994 Apr 22;269(16):11769–11775. [PubMed] [Google Scholar]
  148. Roshak A., Sathe G., Marshall L. A. Suppression of monocyte 85-kDa phospholipase A2 by antisense and effects on endotoxin-induced prostaglandin biosynthesis. J Biol Chem. 1994 Oct 21;269(42):25999–26005. [PubMed] [Google Scholar]
  149. Rzymkiewicz D. M., DuMaine J., Morrison A. R. IL-1 beta regulates rat mesangial cyclooxygenase II gene expression by tyrosine phosphorylation. Kidney Int. 1995 May;47(5):1354–1363. doi: 10.1038/ki.1995.191. [DOI] [PubMed] [Google Scholar]
  150. Salvemini D., Manning P. T., Zweifel B. S., Seibert K., Connor J., Currie M. G., Needleman P., Masferrer J. L. Dual inhibition of nitric oxide and prostaglandin production contributes to the antiinflammatory properties of nitric oxide synthase inhibitors. J Clin Invest. 1995 Jul;96(1):301–308. doi: 10.1172/JCI118035. [DOI] [PMC free article] [PubMed] [Google Scholar]
  151. Salvemini D., Misko T. P., Masferrer J. L., Seibert K., Currie M. G., Needleman P. Nitric oxide activates cyclooxygenase enzymes. Proc Natl Acad Sci U S A. 1993 Aug 1;90(15):7240–7244. doi: 10.1073/pnas.90.15.7240. [DOI] [PMC free article] [PubMed] [Google Scholar]
  152. Salvemini D., Seibert K., Masferrer J. L., Misko T. P., Currie M. G., Needleman P. Endogenous nitric oxide enhances prostaglandin production in a model of renal inflammation. J Clin Invest. 1994 May;93(5):1940–1947. doi: 10.1172/JCI117185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  153. Salvemini D., Settle S. L., Masferrer J. L., Seibert K., Currie M. G., Needleman P. Regulation of prostaglandin production by nitric oxide; an in vivo analysis. Br J Pharmacol. 1995 Mar;114(6):1171–1178. doi: 10.1111/j.1476-5381.1995.tb13330.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  154. Sasaki H., Fukushima M. Prostaglandins in the treatment of cancer. Anticancer Drugs. 1994 Apr;5(2):131–138. doi: 10.1097/00001813-199404000-00002. [DOI] [PubMed] [Google Scholar]
  155. Sautebin L., Di Rosa M. Nitric oxide modulates prostacyclin biosynthesis in the lung of endotoxin-treated rats. Eur J Pharmacol. 1994 Sep 1;262(1-2):193–196. doi: 10.1016/0014-2999(94)90047-7. [DOI] [PubMed] [Google Scholar]
  156. Sautebin L., Ialenti A., Ianaro A., Di Rosa M. Modulation by nitric oxide of prostaglandin biosynthesis in the rat. Br J Pharmacol. 1995 Jan;114(2):323–328. doi: 10.1111/j.1476-5381.1995.tb13230.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  157. Schreck R., Baeuerle P. A. A role for oxygen radicals as second messengers. Trends Cell Biol. 1991 Aug;1(2-3):39–42. doi: 10.1016/0962-8924(91)90072-h. [DOI] [PubMed] [Google Scholar]
  158. Seibert K., Zhang Y., Leahy K., Hauser S., Masferrer J., Perkins W., Lee L., Isakson P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12013–12017. doi: 10.1073/pnas.91.25.12013. [DOI] [PMC free article] [PubMed] [Google Scholar]
  159. Shaw G., Kamen R. A conserved AU sequence from the 3' untranslated region of GM-CSF mRNA mediates selective mRNA degradation. Cell. 1986 Aug 29;46(5):659–667. doi: 10.1016/0092-8674(86)90341-7. [DOI] [PubMed] [Google Scholar]
  160. Shibata Y. Prostaglandin E2 release triggered by phagocytosis of latex particles. A distinct association with prostaglandin synthase isozymes in bone marrow macrophages. J Immunol. 1995 Mar 15;154(6):2878–2887. [PubMed] [Google Scholar]
  161. Shimokawa T., Smith W. L. Prostaglandin endoperoxide synthase. The aspirin acetylation region. J Biol Chem. 1992 Jun 15;267(17):12387–12392. [PubMed] [Google Scholar]
  162. Sirois J., Levy L. O., Simmons D. L., Richards J. S. Characterization and hormonal regulation of the promoter of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Identification of functional and protein-binding regions. J Biol Chem. 1993 Jun 5;268(16):12199–12206. [PubMed] [Google Scholar]
  163. Sirois J., Richards J. S. Transcriptional regulation of the rat prostaglandin endoperoxide synthase 2 gene in granulosa cells. Evidence for the role of a cis-acting C/EBP beta promoter element. J Biol Chem. 1993 Oct 15;268(29):21931–21938. [PubMed] [Google Scholar]
  164. Slater D. M., Berger L. C., Newton R., Moore G. E., Bennett P. R. Expression of cyclooxygenase types 1 and 2 in human fetal membranes at term. Am J Obstet Gynecol. 1995 Jan;172(1 Pt 1):77–82. doi: 10.1016/0002-9378(95)90087-x. [DOI] [PubMed] [Google Scholar]
  165. Slater D., Berger L., Newton R., Moore G., Bennett P. The relative abundance of type 1 to type 2 cyclo-oxygenase mRNA in human amnion at term. Biochem Biophys Res Commun. 1994 Jan 14;198(1):304–308. doi: 10.1006/bbrc.1994.1043. [DOI] [PubMed] [Google Scholar]
  166. Sowa G., Przewłocki R. cAMP analogues and cholera toxin stimulate the accumulation of nitrite in rat peritoneal macrophage cultures. Eur J Pharmacol. 1994 Jan 15;266(2):125–129. doi: 10.1016/0922-4106(94)90101-5. [DOI] [PubMed] [Google Scholar]
  167. Stroebel M., Goppelt-Struebe M. Signal transduction pathways responsible for serotonin-mediated prostaglandin G/H synthase expression in rat mesangial cells. J Biol Chem. 1994 Sep 16;269(37):22952–22957. [PubMed] [Google Scholar]
  168. Swierkosz T. A., Mitchell J. A., Warner T. D., Botting R. M., Vane J. R. Co-induction of nitric oxide synthase and cyclo-oxygenase: interactions between nitric oxide and prostanoids. Br J Pharmacol. 1995 Apr;114(7):1335–1342. doi: 10.1111/j.1476-5381.1995.tb13353.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  169. Szczepanski A., Moatter T., Carley W. W., Gerritsen M. E. Induction of cyclooxygenase II in human synovial microvessel endothelial cells by interleukin-1. Inhibition by glucocorticoids. Arthritis Rheum. 1994 Apr;37(4):495–503. doi: 10.1002/art.1780370409. [DOI] [PubMed] [Google Scholar]
  170. Tahara M., Tasaka K., Masumoto N., Adachi K., Adachi H., Ikebuchi Y., Kurachi H., Miyake A. Expression of messenger ribonucleic acid for epidermal growth factor (EGF), transforming growth factor-alpha (TGF alpha), and EGF receptor in human amnion cells: possible role of TGF alpha in prostaglandin E2 synthesis and cell proliferation. J Clin Endocrinol Metab. 1995 Jan;80(1):138–146. doi: 10.1210/jcem.80.1.7829602. [DOI] [PubMed] [Google Scholar]
  171. Takahashi Y., Taketani Y., Endo T., Yamamoto S., Kumegawa M. Studies on the induction of cyclooxygenase isozymes by various prostaglandins in mouse osteoblastic cell line with reference to signal transduction pathways. Biochim Biophys Acta. 1994 May 13;1212(2):217–224. doi: 10.1016/0005-2760(94)90256-9. [DOI] [PubMed] [Google Scholar]
  172. Tanaka K., Kawasaki H., Kurata K., Aikawa Y., Tsukamoto Y., Inaba T. T-614, a novel antirheumatic drug, inhibits both the activity and induction of cyclooxygenase-2 (COX-2) in cultured fibroblasts. Jpn J Pharmacol. 1995 Apr;67(4):305–314. doi: 10.1254/jjp.67.305. [DOI] [PubMed] [Google Scholar]
  173. Tay A., Squire J. A., Goldberg H., Skorecki K. Assignment of the human prostaglandin-endoperoxide synthase 2 (PTGS2) gene to 1q25 by fluorescence in situ hybridization. Genomics. 1994 Oct;23(3):718–719. doi: 10.1006/geno.1994.1569. [DOI] [PubMed] [Google Scholar]
  174. Tazawa R., Xu X. M., Wu K. K., Wang L. H. Characterization of the genomic structure, chromosomal location and promoter of human prostaglandin H synthase-2 gene. Biochem Biophys Res Commun. 1994 Aug 30;203(1):190–199. doi: 10.1006/bbrc.1994.2167. [DOI] [PubMed] [Google Scholar]
  175. Teixeira F. J., Zakar T., Hirst J. J., Guo F., Sadowsky D. W., Machin G., Demianczuk N., Resch B., Olson D. M. Prostaglandin endoperoxide-H synthase (PGHS) activity and immunoreactive PGHS-1 and PGHS-2 levels in human amnion throughout gestation, at term, and during labor. J Clin Endocrinol Metab. 1994 Jun;78(6):1396–1402. doi: 10.1210/jcem.78.6.8200943. [DOI] [PubMed] [Google Scholar]
  176. Tetsuka T., Daphna-Iken D., Srivastava S. K., Baier L. D., DuMaine J., Morrison A. R. Cross-talk between cyclooxygenase and nitric oxide pathways: prostaglandin E2 negatively modulates induction of nitric oxide synthase by interleukin 1. Proc Natl Acad Sci U S A. 1994 Dec 6;91(25):12168–12172. doi: 10.1073/pnas.91.25.12168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  177. Tomlinson A., Appleton I., Moore A. R., Gilroy D. W., Willis D., Mitchell J. A., Willoughby D. A. Cyclo-oxygenase and nitric oxide synthase isoforms in rat carrageenin-induced pleurisy. Br J Pharmacol. 1994 Nov;113(3):693–698. doi: 10.1111/j.1476-5381.1994.tb17048.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  178. Topley N., Petersen M. M., Mackenzie R., Neubauer A., Stylianou E., Kaever V., Davies M., Coles G. A., Jörres A., Williams J. D. Human peritoneal mesothelial cell prostaglandin synthesis: induction of cyclooxygenase mRNA by peritoneal macrophage-derived cytokines. Kidney Int. 1994 Sep;46(3):900–909. doi: 10.1038/ki.1994.348. [DOI] [PubMed] [Google Scholar]
  179. Tordjman C., Coge F., Andre N., Rique H., Spedding M., Bonnet J. Characterisation of cyclooxygenase 1 and 2 expression in mouse resident peritoneal macrophages in vitro; interactions of non steroidal anti-inflammatory drugs with COX2. Biochim Biophys Acta. 1995 May 17;1256(2):249–256. doi: 10.1016/0005-2760(95)00026-9. [DOI] [PubMed] [Google Scholar]
  180. Tsai A. How does NO activate hemeproteins? FEBS Lett. 1994 Mar 21;341(2-3):141–145. doi: 10.1016/0014-5793(94)80445-1. [DOI] [PubMed] [Google Scholar]
  181. Tsai A., Hsi L. C., Kulmacz R. J., Palmer G., Smith W. L. Characterization of the tyrosyl radicals in ovine prostaglandin H synthase-1 by isotope replacement and site-directed mutagenesis. J Biol Chem. 1994 Feb 18;269(7):5085–5091. [PubMed] [Google Scholar]
  182. Tsujii M., DuBois R. N. Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2. Cell. 1995 Nov 3;83(3):493–501. doi: 10.1016/0092-8674(95)90127-2. [DOI] [PubMed] [Google Scholar]
  183. Ulevitch R. J., Tobias P. S. Recognition of endotoxin by cells leading to transmembrane signaling. Curr Opin Immunol. 1994 Feb;6(1):125–130. doi: 10.1016/0952-7915(94)90043-4. [DOI] [PubMed] [Google Scholar]
  184. Vodovotz Y., Bogdan C. Control of nitric oxide synthase expression by transforming growth factor-beta: implications for homeostasis. Prog Growth Factor Res. 1994;5(4):341–351. doi: 10.1016/0955-2235(94)00004-5. [DOI] [PubMed] [Google Scholar]
  185. Warnock L. J., Hunninghake G. W. Multiple second messenger pathways regulate IL-1 beta-induced expression of PGHS-2 mRNA in normal human skin fibroblasts. J Cell Physiol. 1995 Apr;163(1):172–178. doi: 10.1002/jcp.1041630120. [DOI] [PubMed] [Google Scholar]
  186. Weithmann K. U., Jeske S., Schlotte V. Effect of leflunomide on constitutive and inducible pathways of cellular eicosanoid generation. Agents Actions. 1994 May;41(3-4):164–170. doi: 10.1007/BF02001911. [DOI] [PubMed] [Google Scholar]
  187. Whittle B. J. Thirteenth Gaddum Memorial Lecture. Neuronal and endothelium-derived mediators in the modulation of the gastric microcirculation: integrity in the balance. Br J Pharmacol. 1993 Sep;110(1):3–17. doi: 10.1111/j.1476-5381.1993.tb13763.x. [DOI] [PMC free article] [PubMed] [Google Scholar]
  188. Wiesenberg-Böttcher I., Schweizer A., Green J. R., Seltenmeyer Y., Müller K. The pharmacological profile of CGP 28238, a highly potent anti-inflammatory compound. Agents Actions. 1989 Jan;26(1-2):240–242. doi: 10.1007/BF02126625. [DOI] [PubMed] [Google Scholar]
  189. Willis D., Moore A. R., Frederick R., Willoughby D. A. Heme oxygenase: a novel target for the modulation of the inflammatory response. Nat Med. 1996 Jan;2(1):87–90. doi: 10.1038/nm0196-87. [DOI] [PubMed] [Google Scholar]
  190. Willoughby D. A., Colville-Nash P. R., Seed M. P. Inflammation, prostaglandins, and loss of function. J Lipid Mediat. 1993 Mar-Apr;6(1-3):287–293. [PubMed] [Google Scholar]
  191. Xie W., Fletcher B. S., Andersen R. D., Herschman H. R. v-src induction of the TIS10/PGS2 prostaglandin synthase gene is mediated by an ATF/CRE transcription response element. Mol Cell Biol. 1994 Oct;14(10):6531–6539. doi: 10.1128/mcb.14.10.6531. [DOI] [PMC free article] [PubMed] [Google Scholar]
  192. Xie W., Merrill J. R., Bradshaw W. S., Simmons D. L. Structural determination and promoter analysis of the chicken mitogen-inducible prostaglandin G/H synthase gene and genetic mapping of the murine homolog. Arch Biochem Biophys. 1993 Jan;300(1):247–252. doi: 10.1006/abbi.1993.1034. [DOI] [PubMed] [Google Scholar]
  193. Xu X., Williams J. W., Bremer E. G., Finnegan A., Chong A. S. Inhibition of protein tyrosine phosphorylation in T cells by a novel immunosuppressive agent, leflunomide. J Biol Chem. 1995 May 26;270(21):12398–12403. doi: 10.1074/jbc.270.21.12398. [DOI] [PubMed] [Google Scholar]
  194. Yamagata K., Andreasson K. I., Kaufmann W. E., Barnes C. A., Worley P. F. Expression of a mitogen-inducible cyclooxygenase in brain neurons: regulation by synaptic activity and glucocorticoids. Neuron. 1993 Aug;11(2):371–386. doi: 10.1016/0896-6273(93)90192-t. [DOI] [PubMed] [Google Scholar]
  195. Yamamoto K., Arakawa T., Ueda N., Yamamoto S. Transcriptional roles of nuclear factor kappa B and nuclear factor-interleukin-6 in the tumor necrosis factor alpha-dependent induction of cyclooxygenase-2 in MC3T3-E1 cells. J Biol Chem. 1995 Dec 29;270(52):31315–31320. doi: 10.1074/jbc.270.52.31315. [DOI] [PubMed] [Google Scholar]
  196. Yang C. Y., Meng C. L. Regulation of PG synthase by EGF and PDGF in human oral, breast, stomach, and fibrosarcoma cancer cell lines. J Dent Res. 1994 Aug;73(8):1407–1415. doi: 10.1177/00220345940730080301. [DOI] [PubMed] [Google Scholar]
  197. Yano T., Hopkins H. A., Hempel S. L., Monick M., Hunninghake G. W. Interleukin-4 inhibits lipopolysaccharide-induced expression of prostaglandin H synthase-2 in human alveolar macrophages. J Cell Physiol. 1995 Oct;165(1):77–82. doi: 10.1002/jcp.1041650110. [DOI] [PubMed] [Google Scholar]
  198. Yu K., Bayona W., Kallen C. B., Harding H. P., Ravera C. P., McMahon G., Brown M., Lazar M. A. Differential activation of peroxisome proliferator-activated receptors by eicosanoids. J Biol Chem. 1995 Oct 13;270(41):23975–23983. doi: 10.1074/jbc.270.41.23975. [DOI] [PubMed] [Google Scholar]
  199. Zakar T., Hirst J. J., Mijovic J. E., Olson D. M. Glucocorticoids stimulate the expression of prostaglandin endoperoxide H synthase-2 in amnion cells. Endocrinology. 1995 Apr;136(4):1610–1619. doi: 10.1210/endo.136.4.7895671. [DOI] [PubMed] [Google Scholar]
  200. Zakar T., Teixeira F. J., Hirst J. J., Guo F., MacLeod E. A., Olson D. M. Regulation of prostaglandin endoperoxide H synthase by glucocorticoids and activators of protein kinase C in the human amnion. J Reprod Fertil. 1994 Jan;100(1):43–50. doi: 10.1530/jrf.0.1000043. [DOI] [PubMed] [Google Scholar]
  201. Zuo J., Lei Z. M., Rao C. V., Pietrantoni M., Cook V. D. Differential cyclooxygenase-1 and -2 gene expression in human myometria from preterm and term deliveries. J Clin Endocrinol Metab. 1994 Sep;79(3):894–899. doi: 10.1210/jcem.79.3.8077379. [DOI] [PubMed] [Google Scholar]
  202. te Velde A. A., Huijbens R. J., Heije K., de Vries J. E., Figdor C. G. Interleukin-4 (IL-4) inhibits secretion of IL-1 beta, tumor necrosis factor alpha, and IL-6 by human monocytes. Blood. 1990 Oct 1;76(7):1392–1397. [PubMed] [Google Scholar]

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