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. 1976;54(5):523–532.

Epidemiological features of choriocarcinoma

Jane C Baltazar
PMCID: PMC2366480  PMID: 1088402

Abstract

By means of hospital records and death certificates, 91 cases of choriocarcinoma were identified in the cities of Manila, Quezon, Pasay, and Caloocan in the Philippines during the 5 years 1970-74. The overall incidence was 17.4 per 100 000 live births. The other principal findings in this population-based study concerned maternal age, history of fetal wastage, and number of pregnancies. Very high incidence rates for choriocarcinoma were registered for mothers aged 40 years and over and there was a slightly higher than average risk for women under 20 years of age. Risk increased with the number of fetal losses. The effect of number of pregnancies was evident only for very old and very young mothers. A case—control study was also conducted on 28 patients with choriocarcinoma and on 187 age-matched controls; for all of these women, the disease had been diganosed (cases) or children had been born (controls) between 1970 and 1975. Compared with the control group, a higher proportion of the case group had a history of pulmonary tuberculosis and had previously used contraceptive pills. Because of the low and unequal levels of cooperation among patients and controls, these findings need further confirmation.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Aranda J. M., Martinez I. Incidence of choriocarcinoma in Puerto Rico. A 15-year study. Cancer. 1969 Feb;23(2):506–507. doi: 10.1002/1097-0142(196902)23:2<506::aid-cncr2820230232>3.0.co;2-q. [DOI] [PubMed] [Google Scholar]
  2. CHAN D. P. Chorionepithelioma. A study of 41 cases. Br Med J. 1962 Oct 13;2(5310):953–957. doi: 10.1136/bmj.2.5310.953. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Dawood M. Y., Teoh E. S., Ratnam S. S. ABO blood group in trophoblastic disease. J Obstet Gynaecol Br Commonw. 1971 Oct;78(10):918–923. doi: 10.1111/j.1471-0528.1971.tb00204.x. [DOI] [PubMed] [Google Scholar]
  4. De George F. V. Hydatidiform moles in other pregnancies of mothers of twins. Am J Obstet Gynecol. 1970 Oct 1;108(3):369–371. doi: 10.1016/0002-9378(70)90416-3. [DOI] [PubMed] [Google Scholar]
  5. Gore H. Trophoblastic disease. Ala J Med Sci. 1972 Jul;9(3):289–298. [PubMed] [Google Scholar]
  6. MILLS W. CHORION-CARCINOMA IN THE MIDLANDS. Clin Radiol. 1964 Jul;15:260–262. doi: 10.1016/s0009-9260(64)80078-7. [DOI] [PubMed] [Google Scholar]
  7. Matalon M., Paz B., Modan M., Modan B. Malignant trophoblastic disorders. Epidemiologic aspects and relationship to hydatidiform mole. Am J Obstet Gynecol. 1972 Jan 1;112(1):101–106. [PubMed] [Google Scholar]
  8. McCorriston C. C. Racial incidence of hydatidiform mole. A study in a contained polyracial community. Am J Obstet Gynecol. 1968 Jun 1;101(3):377–382. doi: 10.1016/0002-9378(68)90068-9. [DOI] [PubMed] [Google Scholar]
  9. NOVAK E., SEAH C. S. Choriocarcinoma of the uterus; study of 74 cases from the Mathieu Memorial Chorionepithelioma Registry. Am J Obstet Gynecol. 1954 May;67(5):933–957. [PubMed] [Google Scholar]
  10. Natoli W. J., Rashad M. N. Hawaiian moles. Am J Roentgenol Radium Ther Nucl Med. 1972 Jan;114(1):142–144. [PubMed] [Google Scholar]
  11. Reddy D. B., Rao N. Trophoblastic tumours. I. Hydatidiform mole (review based on a study of 135 cases). Indian J Med Sci. 1969 Oct;23(10):527–531. [PubMed] [Google Scholar]
  12. Shanmugaratnam K., Muir C. S., Tow S. H., Cheng W. C., Christine B., Pedersen E. Rates per 100,000 births and incidence of choriocarcinoma and malignant mole in Singapore Chinese and Malays. Comparison with Connecticut, Norway and Sweden. Int J Cancer. 1971 Jul 15;8(1):165–175. doi: 10.1002/ijc.2910080120. [DOI] [PubMed] [Google Scholar]
  13. Steigrad S. J. The incidence of neoplastic trophoblastic disease in Australia. Aust N Z J Obstet Gynaecol. 1969 May;9(2):100–102. doi: 10.1111/j.1479-828x.1969.tb02538.x. [DOI] [PubMed] [Google Scholar]
  14. Teoh E. S., Dawood M. Y., Ratnam S. S. Epidemiology of hydatidiform mole in Singapore. Am J Obstet Gynecol. 1971 Jun 1;110(3):415–420. doi: 10.1016/0002-9378(71)90741-1. [DOI] [PubMed] [Google Scholar]
  15. Teoh E. S., Dawood M. Y., Ratnam S. S. Observations on choriocarcinoma in Singapore. Obstet Gynecol. 1972 Oct;40(4):519–524. [PubMed] [Google Scholar]
  16. Yen S., MacMahon B. Epidemiologic features of trophoblastic disease. Am J Obstet Gynecol. 1968 May 1;101(1):126–132. doi: 10.1016/0002-9378(68)90497-3. [DOI] [PubMed] [Google Scholar]

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