Abstract
A test for monkeypox-specific antibodies is described. Monkeypox immune sera can be made type-specific by immunoabsorption with heterotypic poxvirus extracts. Monkeypox-specific antibodies were demonstrated in sera from 9 cynomolgus monkeys (Macaca fascicularis) that had previously been experimentally infected with monkeypox. Monkeypox-specific antibodies were found in 3 wild-caught African monkeys (Cercopithecus spp.) and in 3 human sera collected from Africans in the Ivory Coast and Nigeria 3½-4 years after they had suffered a pox-like infection. Monkeypox had been recognized in one of the patients by virus isolation, and had been suspected in the others for epidemiological reasons. Vaccinia-specific antibodies were found in 4 human sera collected 6 weeks after smallpox vaccination.
The serological results provide the first laboratory evidence of a monkeypox reservoir in wild monkeys.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Arita I., Henderson D. A. Smallpox and monkeypox in non-human primates. Bull World Health Organ. 1968;39(2):277–283. [PMC free article] [PubMed] [Google Scholar]
- Gispen R., Brand-Saathof B. "White" poxvirus strains from monkeys. Bull World Health Organ. 1972;46(5):585–592. [PMC free article] [PubMed] [Google Scholar]
- Gispen R., Brand-Saathof B. Three specific antigens produced in vaccinia, variola, and monkeypox infections. J Infect Dis. 1974 Mar;129(3):289–295. doi: 10.1093/infdis/129.3.289. [DOI] [PubMed] [Google Scholar]
- Gispen R., Huisman J., Brand-Saathof B., Hekker A. C. Immunofluorescence test for persistent poxvirus antibodies. Arch Gesamte Virusforsch. 1974;44(4):391–395. doi: 10.1007/BF01251021. [DOI] [PubMed] [Google Scholar]
- Gispen R., Verlinde J. D., Zwart P. Histopathological and virological studies on monkeypox. Arch Gesamte Virusforsch. 1967;21(2):205–216. doi: 10.1007/BF01241445. [DOI] [PubMed] [Google Scholar]
- Marennikova S. S., Seluhina E. M., Mal'ceva N. N., Ladnyj I. D. Poxviruses isolated from clinically ill and asymptomatically infected monkeys and a chimpanzee. Bull World Health Organ. 1972;46(5):613–620. [PMC free article] [PubMed] [Google Scholar]