Abstract
Experimental Machupo virus infection of rhesus and cynomolgus monkeys produced a severe illness consisting of an initial clinical phase and a later neurological phase. Cumulative mortality during the two phases was 80% and 95% respectively. Attempts to alter the pathogenesis with decomplementation or immunosuppression resulted in earlier deaths of the monkeys.
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Selected References
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- Earley E., Peralta P. H., Johnson K. M. A plaque neutralization method for arboviruses. Proc Soc Exp Biol Med. 1967 Jul;125(3):741–747. doi: 10.3181/00379727-125-32194. [DOI] [PubMed] [Google Scholar]
- JOHNSON K. M., WIEBENGA N. H., MACKENZIE R. B., KUNS M. L., TAURASO N. M., SHELOKOV A., WEBB P. A., JUSTINES G., BEYE H. K. VIRUS ISOLATIONS FROM HUMAN CASES OF HEMORRHAGIC FEVER IN BOLIVIA. Proc Soc Exp Biol Med. 1965 Jan;118:113–118. doi: 10.3181/00379727-118-29772. [DOI] [PubMed] [Google Scholar]
- Oldstone M. B., Dixon F. J. Pathogenesis of chronic disease associated with persistent lymphocytic choriomeningitis viral infection. II. Relationship of the anti-lymphocytic choriomeningitis immune response to tissue injury in chronic lymphocytic choriomeningitis disease. J Exp Med. 1970 Jan 1;131(1):1–19. doi: 10.1084/jem.131.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Peters C. J., Kuehne R. W., Mercado R. R., Le Bow R. H., Spertzel R. O., Webb P. A. Hemorrhagic fever in Cochabamba, Bolivia, 1971. Am J Epidemiol. 1974 Jun;99(6):425–433. doi: 10.1093/oxfordjournals.aje.a121631. [DOI] [PubMed] [Google Scholar]
- Webb P. A., Johnson K. M., Mackenzie R. B. The measurement of specific antibodies in Bolivian hemorrhagic fever by neutralization of virus plaques. Proc Soc Exp Biol Med. 1969 Mar;130(3):1013–1019. doi: 10.3181/00379727-130-33711. [DOI] [PubMed] [Google Scholar]