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. 1994 Jun;68(6):4039–4042. doi: 10.1128/jvi.68.6.4039-4042.1994

Glycosylphosphatidylinositol-anchored CD4 supports human immunodeficiency virus type 1 replication, but not cytopathic effect, in T-cell transfectants.

W L Marshall 1, E S Mittler 1, P Avery 1, J P Lawrence 1, R W Finberg 1
PMCID: PMC236913  PMID: 8189539

Abstract

Despite equivalent p24 antigen production, HSB-2 T cells expressing glycosylphosphatidylinositol (GPi)-linked CD4 were productively infected without cell death or syncytium formation, unlike HSB-2 transfectants expressing wild-type CD4 (wtCD4). HSB-2 transfectants dually expressing wtCD4 and GPi-linked CD4 formed syncytia and died. Thus, wtCD4 expression is critical for human immunodeficiency virus cytopathic effect in HSB-2 transfectants.

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Selected References

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