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. 1994 Sep;68(9):6083–6086. doi: 10.1128/jvi.68.9.6083-6086.1994

Respiratory virus infection of mice provokes a permanent humoral immune response.

L Hyland 1, M Sangster 1, R Sealy 1, C Coleclough 1
PMCID: PMC237018  PMID: 8057487

Abstract

We have observed that respiratory virus infection of mice provokes an extremely persistent humoral immune reaction, due to a long-sustained population of antibody-secreting cells in the bone marrow. Theories of humoral immunity that strongly distinguish primary and secondary reactions thus may not adequately describe the immune response to respiratory viruses.

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Selected References

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