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. 1994 Oct;68(10):6824–6828. doi: 10.1128/jvi.68.10.6824-6828.1994

Characterization of a novel binding site for the human immunodeficiency virus type 1 envelope protein gp120 on human fetal astrocytes.

M Ma 1, J D Geiger 1, A Nath 1
PMCID: PMC237112  PMID: 8084022

Abstract

125I-labeled recombinant gp120 bound to primary cultures of human fetal astrocytes with a single class of 260-kDa binding sites, with a Kd of 26 nM and maximal number of binding sites of 29.9 fmol/4 x 10(4) cells. Neither CD4 nor galactocerebroside was detectable on astrocytes, and 125I-labeled recombinant gp120 binding to astrocytes was not blocked by antibodies against galactocerebroside or the gp120 binding domain of CD4.

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Selected References

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