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. 1994 Nov;68(11):7540–7545. doi: 10.1128/jvi.68.11.7540-7545.1994

Apoptosis induced in mouse hepatitis virus-infected cells by a virus-specific CD8+ cytotoxic T-lymphocyte clone.

S Shibata 1, S Kyuwa 1, S K Lee 1, Y Toyoda 1, N Goto 1
PMCID: PMC237198  PMID: 7933139

Abstract

Morphological changes of mouse hepatitis virus-infected J774.1 cells cocultured with cloned mouse hepatitis virus-specific CD8+ cytotoxic T lymphocytes were examined by electron microscopy. Condensation and margination of chromatin, cellular shrinkage with severe vacuolar degeneration, and blebbing were observed. In addition, fragmentation of cellular DNA was observed, and a decrease in virus titer was accompanied by those changes. These findings show that the cloned cytotoxic T lymphocytes induce in the target cell an internal degradation program termed apoptosis, which results in virus clearance.

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Selected References

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