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. 1993 Feb;67(2):1075–1079. doi: 10.1128/jvi.67.2.1075-1079.1993

Measles virus-induced changes in leukocyte function antigen 1 expression and leukocyte aggregation: possible role in measles virus pathogenesis.

N Attibele 1, P R Wyde 1, J Trial 1, S C Smole 1, C W Smith 1, R D Rossen 1
PMCID: PMC237463  PMID: 8093488

Abstract

Measles virus (MV) infection of U937 cell or peripheral blood leukocyte cultures was shown to induce changes in the expression of leukocyte function antigen 1 (LFA-1) and cause marked aggregation of these cells. Addition of selected monoclonal antibodies specific for LFA-1 epitopes that did not neutralize MV in standard neutralization assays were found to block both virus-induced leukocyte aggregation and virus dissemination. These data suggest that MV modulation of LFA-1 expression on leukocytes may be an important step in MV pathogenesis.

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Selected References

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