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. 1993 Mar;67(3):1716–1720. doi: 10.1128/jvi.67.3.1716-1720.1993

Identification of a short amino acid sequence essential for efficient nuclear targeting of the Epstein-Barr virus nuclear antigen 3A.

A Le Roux 1, M Berebbi 1, M Moukaddem 1, M Perricaudet 1, I Joab 1
PMCID: PMC237550  PMID: 8382317

Abstract

The Epstein-Barr virus nuclear antigen 3A is expressed in the nuclei of cells latently infected by the Epstein-Barr virus. We have previously shown that a fragment of 265 amino acids was essential for the proper subcellular localization of the Epstein-Barr virus nuclear antigen 3A. As described in this paper, we have used deletion analysis to identify a decapeptide, RDRRRNPASR, which is essential for nuclear localization of this protein. Furthermore, this decapeptide is a functional nuclear localization signal as demonstrated by its ability to target expression of beta-galactosidase in the nuclei of transfected cells.

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Selected References

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