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. 1977 Dec;23:60, 62-63, 65, 67-68.

The Prevention of Rh-Immunization

John M Bowman
PMCID: PMC2379019  PMID: 20469282

Abstract

Administration of Rh immune globulin to the Rh-negative unimmunized woman at risk of Rh-immunization is highly effective if given in sufficient dose prior to active Rh-immunization. Remaining problems are: 1. treating all of those at risk, 2. protecting those who abort, 3. treating after amniocentesis, 4. instituting an antenatal prophylaxis program to protect the 1.8 percent immunized too early to be protected by post-delivery injection of Rh immune globulin, 5. protecting those who have had massive transplacental fetal hemorrhages. All physicians practicing obstetrics should ensure that all of their unimmunized Rh-negative women are protected against Rh-immunization.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bowen F. W., Jr, Renfield M. The detection of anti-D in Rho (D)-negative infants born of Rho (D)-positive mothers. Pediatr Res. 1976 Apr;10(4):213–215. doi: 10.1203/00006450-197604000-00001. [DOI] [PubMed] [Google Scholar]
  2. CHOWN B. Anaemia from bleeding of the fetus into the mother's circulation. Lancet. 1954 Jun 12;266(6824):1213–1215. doi: 10.1016/s0140-6736(54)92446-0. [DOI] [PubMed] [Google Scholar]
  3. FINN R., CLARKE C. A., DONOHOE W. T., McCONNELL R. B., SHEPPARD P. M., LEHANE D., KULKE W. Experimental studies on the prevention of Rh haemolytic disease. Br Med J. 1961 May 27;1(5238):1486–1490. doi: 10.1136/bmj.1.5238.1486. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. FREDA V. J., GORMAN J. G., POLLACK W. SUCCESSFUL PREVENTION OF EXPERIMENTAL RH SENSITIZATION IN MAN WITH AN ANTI-RH GAMMA2-GLOBULIN ANTIBODY PREPARATION: A PRELIMINARY REPORT. Transfusion. 1964 Jan-Feb;4:26–32. doi: 10.1111/j.1537-2995.1964.tb02824.x. [DOI] [PubMed] [Google Scholar]
  5. Hoppe H. H., Mester T., Hennig W., Krebs H. J. Prevention of Rh-immunization. Modified production of IgG anti-Rh for intravenous application by ion exchange chromatography (IEC). Vox Sang. 1973 Oct;25(4):308–316. doi: 10.1111/j.1423-0410.1973.tb04378.x. [DOI] [PubMed] [Google Scholar]
  6. KLEIHAUER E., BRAUN H., BETKE K. Demonstration von fetalem Hämoglobin in den Erythrocyten eines Blutausstrichs. Klin Wochenschr. 1957 Jun 15;35(12):637–638. doi: 10.1007/BF01481043. [DOI] [PubMed] [Google Scholar]
  7. Peddle L. J. Increase of antibody titer following amniocentesis. Am J Obstet Gynecol. 1968 Feb 15;100(4):567–569. doi: 10.1016/s0002-9378(15)33494-3. [DOI] [PubMed] [Google Scholar]
  8. Pollack W., Ascari W. Q., Kochesky R. J., O'Connor R. R., Ho T. Y., Tripodi D. Studies on Rh prophylaxis. 1. Relationship between doses of anti-Rh and size of antigenic stimulus. Transfusion. 1971 Nov-Dec;11(6):333–339. doi: 10.1111/j.1537-2995.1971.tb04424.x. [DOI] [PubMed] [Google Scholar]
  9. Rivat L., Rivat C., Parent M., Ropartz C. Accident survenu après injection de gamma-globulines anti-Rh dû à la présence d'anticorps anti-gammaA. Presse Med. 1970 Nov 7;78(47):2072–2072. [PubMed] [Google Scholar]
  10. Samson D., Mollison P. L. Effect on primary Rh immunization of delayed administration of anti-Rh. Immunology. 1975 Feb;28(2):349–357. [PMC free article] [PubMed] [Google Scholar]
  11. Wallerstein H. Treatment of Severe Erythroblastosis by Simultaneous Removal and Replacement of the Blood of the Newborn Infant. Science. 1946 May 10;103(2680):583–584. doi: 10.1126/science.103.2680.583. [DOI] [PubMed] [Google Scholar]
  12. Zipursky A., Israels L. G. The pathogenesis and prevention of Rh immunization. Can Med Assoc J. 1967 Nov 18;97(21):1245–1257. [PMC free article] [PubMed] [Google Scholar]

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