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Canadian Family Physician logoLink to Canadian Family Physician
. 1993 Oct;39:2122–2127.

Using pyridoxine to treat carpal tunnel syndrome. Randomized control trial.

G R Spooner 1, H B Desai 1, J F Angel 1, B A Reeder 1, J R Donat 1
PMCID: PMC2379872  PMID: 8219859

Abstract

In this study, we examined prospectively the effect of pyridoxine on idiopathic carpal tunnel syndrome. Thirty-two patients with the disease were randomized to receive treatment or placebo. No differences in outcome were found in electrophysiologic signs, clinical signs, or significant symptoms. Our findings do not support the use of pyridoxine for treating carpal tunnel syndrome.

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Selected References

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  1. Berger A., Schaumburg H. H. More on neuropathy from pyridoxine abuse. N Engl J Med. 1984 Oct 11;311(15):986–987. [PubMed] [Google Scholar]
  2. Bernstein A. L. Vitamin B6 in clinical neurology. Ann N Y Acad Sci. 1990;585:250–260. doi: 10.1111/j.1749-6632.1990.tb28058.x. [DOI] [PubMed] [Google Scholar]
  3. Byers C. M., DeLisa J. A., Frankel D. L., Kraft G. H. Pyridoxine metabolism in carpal tunnel syndrome with and without peripheral neuropathy. Arch Phys Med Rehabil. 1984 Nov;65(11):712–716. [PubMed] [Google Scholar]
  4. Ellis J. M., Folkers K., Levy M., Shizukuishi S., Lewandowski J., Nishii S., Schubert H. A., Ulrich R. Response of vitamin B-6 deficiency and the carpal tunnel syndrome to pyridoxine. Proc Natl Acad Sci U S A. 1982 Dec;79(23):7494–7498. doi: 10.1073/pnas.79.23.7494. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Ellis J. M. Treatment of carpal tunnel syndrome with vitamin B6. South Med J. 1987 Jul;80(7):882–884. doi: 10.1097/00007611-198707000-00018. [DOI] [PubMed] [Google Scholar]
  6. Ellis J., Folkers K., Levy M., Takemura K., Shizukuishi S., Ulrich R., Harrison P. Therapy with vitamin B6 with and without surgery for treatment of patients having the idiopathic carpal tunnel syndrome. Res Commun Chem Pathol Pharmacol. 1981 Aug;33(2):331–344. [PubMed] [Google Scholar]
  7. Foca F. J. Motor and sensory neuropathy secondary to excessive pyridoxine ingestion. Arch Phys Med Rehabil. 1985 Sep;66(9):634–636. [PubMed] [Google Scholar]
  8. Folkers K., Ellis J., Watanabe T., Saji S., Kaji M. Biochemical evidence for a deficiency of vitamin B6 in the carpal tunnel syndrome based on a crossover clinical study. Proc Natl Acad Sci U S A. 1978 Jul;75(7):3410–3412. doi: 10.1073/pnas.75.7.3410. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Gellman H., Gelberman R. H., Tan A. M., Botte M. J. Carpal tunnel syndrome. An evaluation of the provocative diagnostic tests. J Bone Joint Surg Am. 1986 Jun;68(5):735–737. [PubMed] [Google Scholar]
  10. Heywood P. L. Through the carpal tunnel. Br Med J (Clin Res Ed) 1987 Mar 14;294(6573):660–661. doi: 10.1136/bmj.294.6573.660-a. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Hongell A., Mattsson H. S. Neurographic studies before, after, and during operation for median nerve compression in the carpal tunnel. Scand J Plast Reconstr Surg. 1971;5(2):103–109. doi: 10.3109/02844317109042948. [DOI] [PubMed] [Google Scholar]
  12. Kasdan M. L., Janes C. Carpal tunnel syndrome and vitamin B6. Plast Reconstr Surg. 1987 Mar;79(3):456–462. doi: 10.1097/00006534-198703000-00027. [DOI] [PubMed] [Google Scholar]
  13. Katz J. N., Larson M. G., Sabra A., Krarup C., Stirrat C. R., Sethi R., Eaton H. M., Fossel A. H., Liang M. H. The carpal tunnel syndrome: diagnostic utility of the history and physical examination findings. Ann Intern Med. 1990 Mar 1;112(5):321–327. doi: 10.7326/0003-4819-112-5-321. [DOI] [PubMed] [Google Scholar]
  14. Laso Guzmán F. J., González-Buitrago J. M., de Arriba F., Mateos F., Moyano J. C., López-Alburquerque T. Carpal tunnel syndrome and vitamin B6. Klin Wochenschr. 1989 Jan 4;67(1):38–41. doi: 10.1007/BF01736533. [DOI] [PubMed] [Google Scholar]
  15. Mills K. R. Orthodromic sensory action potentials from palmar stimulation in the diagnosis of carpal tunnel syndrome. J Neurol Neurosurg Psychiatry. 1985 Mar;48(3):250–255. doi: 10.1136/jnnp.48.3.250. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Mossman S. S., Blau J. N. Tinel's sign and the carpal tunnel syndrome. Br Med J (Clin Res Ed) 1987 Mar 14;294(6573):680–680. doi: 10.1136/bmj.294.6573.680. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Schaumburg H., Kaplan J., Windebank A., Vick N., Rasmus S., Pleasure D., Brown M. J. Sensory neuropathy from pyridoxine abuse. A new megavitamin syndrome. N Engl J Med. 1983 Aug 25;309(8):445–448. doi: 10.1056/NEJM198308253090801. [DOI] [PubMed] [Google Scholar]
  18. Scheyer R. D., Haas D. C. Pyridoxine in carpal tunnel syndrome. Lancet. 1985 Jul 6;2(8445):42–42. doi: 10.1016/s0140-6736(85)90090-x. [DOI] [PubMed] [Google Scholar]
  19. Shizukuishi S., Nishii S., Ellis J., Folkers K. The carpal tunnel syndrome as a probable primary deficiency of vitamin B6 rather than a deficiency of a dependency state. Biochem Biophys Res Commun. 1980 Aug 14;95(3):1126–1130. doi: 10.1016/0006-291x(80)91589-2. [DOI] [PubMed] [Google Scholar]
  20. Smith G. P., Rudge P. J., Peters T. J. Biochemical studies of pyridoxal and pyridoxal phosphate status and therapeutic trial of pyridoxine in patients with carpal tunnel syndrome. Ann Neurol. 1984 Jan;15(1):104–107. doi: 10.1002/ana.410150120. [DOI] [PubMed] [Google Scholar]
  21. Stevens J. C., Beard C. M., O'Fallon W. M., Kurland L. T. Conditions associated with carpal tunnel syndrome. Mayo Clin Proc. 1992 Jun;67(6):541–548. doi: 10.1016/s0025-6196(12)60461-3. [DOI] [PubMed] [Google Scholar]
  22. Wolaniuk A., Vadhanavikit S., Folkers K. Electromyographic data differentiate patients with the carpal tunnel syndrome when double blindly treated with pyridoxine and placebo. Res Commun Chem Pathol Pharmacol. 1983 Sep;41(3):501–511. [PubMed] [Google Scholar]
  23. de Krom M. C., Knipschild P. G., Kester A. D., Spaans F. Efficacy of provocative tests for diagnosis of carpal tunnel syndrome. Lancet. 1990 Feb 17;335(8686):393–395. doi: 10.1016/0140-6736(90)90218-t. [DOI] [PubMed] [Google Scholar]
  24. de Krom M. C., Knipschild P. G., Kester A. D., Thijs C. T., Boekkooi P. F., Spaans F. Carpal tunnel syndrome: prevalence in the general population. J Clin Epidemiol. 1992 Apr;45(4):373–376. doi: 10.1016/0895-4356(92)90038-o. [DOI] [PubMed] [Google Scholar]

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