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. 1993 Nov;67(11):6815–6819. doi: 10.1128/jvi.67.11.6815-6819.1993

Anti-idiotypic mimicry of a neutralizing epitope on the glycoprotein B complex of human cytomegalovirus.

E S Tackaberry 1, J Hamel 1, Y Larose 1, B R Brodeur 1
PMCID: PMC238124  PMID: 7692085

Abstract

Experiments were carried out to investigate the ability of rabbit anti-idiotype antibodies (Ab2), directed against an anti-human cytomegalovirus monoclonal antibody (Ab1), to induce neutralizing antibodies specific for the immunodominant glycoprotein B viral complex. Mice immunized with Ab2 produced anti-Ab2 (Ab3) that was both antigen and idiotype specific with regard to Ab1. We conclude that the Ab2 antibodies mimicked a neutralizing epitope and acted as a network antigen for inducing a specific anti-human cytomegalovirus antibody response in this experimental system.

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Selected References

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