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. 1993 Nov;67(11):6882–6888. doi: 10.1128/jvi.67.11.6882-6888.1993

Inhibition of Rev activity and human immunodeficiency virus type 1 replication by antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element.

G Li 1, J Lisziewicz 1, D Sun 1, G Zon 1, S Daefler 1, F Wong-Staal 1, R C Gallo 1, M E Klotman 1
PMCID: PMC238137  PMID: 8411393

Abstract

The interaction between the Rev protein of human immunodeficiency virus type 1 and its highly structured and conserved RNA target, the Rev-responsive element, is required for virus replication. We demonstrate that antisense oligodeoxynucleotide phosphorothioate analogs directed against the Rev-responsive element effectively inhibit Rev activity, as well as human immunodeficiency virus type 1 replication, and are candidates for antiviral therapy.

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Selected References

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