Abstract
A single oral dose (1.5 g) of mefloquine hydrochloride cured all of 37 patients with falciparum malaria, and a single dose of pyrimethamine (75 mg) plus sulfadoxine (1.5 g) cured 34 of 38 patients. The rates at which parasitaemia and fever abated were similar for the two regimens but mefloquine was associated with a higher incidence of gastrointestinal side effects.
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Selected References
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- Canfield C. J., Hall A. P., MacDonald B. S., Neuman D. A., Shaw J. A. Treatment of falciparum malaria from Vietnam with a phenanthrene methanol (WR 33063) and a quinoline methanol (WR 30090). Antimicrob Agents Chemother. 1973 Feb;3(2):224–227. doi: 10.1128/aac.3.2.224. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Colwell E. J. A review of the drug sensitivity of Plasmodium falciparum in Thailand. Southeast Asian J Trop Med Public Health. 1972 Jun;3(2):190–197. [PubMed] [Google Scholar]
- Trenholme C. M., Williams R. L., Desjardins R. E., Frischer H., Carson P. E., Rieckmann K. H., Canfield C. J. Mefloquine (WR 142,490) in the treatment of human malaria. Science. 1975 Nov 21;190(4216):792–794. doi: 10.1126/science.1105787. [DOI] [PubMed] [Google Scholar]