Abstract
A 68 year old man presented with a systemic necrotizing vasculitis and elevated levels of anti-neutrophil cytoplasmic antibody (ANCA) which responded to treatment with steroids and cyclophosphamide, with a decrease in the titre of ANCA until its disappearance. Four months later he presented with weakness, loss of weight, aphonia and dysphagia. A computerized tomography scan showed a solid mass in the anterior mediastinum, and histological studies revealed an undifferentiated adenocarcinoma. Vasculitis improved although the malignancy progressed and ANCA was persistently negative. Our case demonstrates an association between ANCA and paraneoplastic vasculitis.
Full text
PDF
Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gibson L. E., Winkelmann R. K. Cutaneous granulomatous vasculitis: its relationship to systemic disease. J Am Acad Dermatol. 1986 Mar;14(3):492–501. doi: 10.1016/s0190-9622(86)70064-9. [DOI] [PubMed] [Google Scholar]
- Greer J. M., Longley S., Edwards N. L., Elfenbein G. J., Panush R. S. Vasculitis associated with malignancy. Experience with 13 patients and literature review. Medicine (Baltimore) 1988 Jul;67(4):220–230. doi: 10.1097/00005792-198807000-00003. [DOI] [PubMed] [Google Scholar]
- Jennette J. C., Wilkman A. S., Falk R. J. Anti-neutrophil cytoplasmic autoantibody-associated glomerulonephritis and vasculitis. Am J Pathol. 1989 Nov;135(5):921–930. [PMC free article] [PubMed] [Google Scholar]
- Longley S., Caldwell J. R., Panush R. S. Paraneoplastic vasculitis. Unique syndrome of cutaneous angiitis and arthritis associated with myeloproliferative disorders. Am J Med. 1986 Jun;80(6):1027–1030. doi: 10.1016/0002-9343(86)90660-1. [DOI] [PubMed] [Google Scholar]
- Mertz L. E., Conn D. L. Vasculitis associated with malignancy. Curr Opin Rheumatol. 1992 Feb;4(1):39–46. [PubMed] [Google Scholar]
- Rivera M., González C., Gonzalo A., Quereda C., Fogué L., Ortuño J. Vasculitis associated with non-Hodgkin's lymphoma. Nephron. 1993;65(1):167–168. doi: 10.1159/000187469. [DOI] [PubMed] [Google Scholar]
- Sánchez-Guerrero J., Gutiérrez-Ureña S., Vidaller A., Reyes E., Iglesias A., Alarcón-Segovia D. Vasculitis as a paraneoplastic syndrome. Report of 11 cases and review of the literature. J Rheumatol. 1990 Nov;17(11):1458–1462. [PubMed] [Google Scholar]