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. 1992 Mar;68(797):225–228. doi: 10.1136/pgmj.68.797.225

Testotoxicosis: gonadotrophin-independent male sexual precocity.

A A Aziz 1, S M Jafri 1, N U Haque 1
PMCID: PMC2399261  PMID: 1589386

Abstract

In this era of rapidly developing investigational tools and pharmacology, the pathophysiology of precocious puberty is becoming well defined. What was previously thought to be a form of gonadotrophin releasing hormone (GNRH)-dependent central precocious puberty is now classified as GNRH-independent familial testotoxicosis. We present two such cases and review the clinical features, pathophysiology and treatment of testotoxicosis.

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Selected References

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