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. 1992 Nov;68(805):900–903. doi: 10.1136/pgmj.68.805.900

The differing predictive values of oestrogen receptor assays for large breast cancers.

D J Gaskell 1, R A Hawkins 1, A L Tesdale 1, K Sangster 1, U Chetty 1, A P Forrest 1
PMCID: PMC2399488  PMID: 1494511

Abstract

Thirty elderly patients with T3 or T4 breast cancer underwent a wedge biopsy for radioligand-binding assay (RLA) of oestrogen receptor (ER) activity. A second, separate group of 21 elderly patients with T3 and T4 breast cancers underwent fine needle aspiration biopsy (FNA) for immunocytochemical assay of ER (ER-ICA). All the women received tamoxifen as primary treatment and response was assessed by UICC criteria. Tumour ER concentration by RLA was correlated with both response (Spearman's R = + 0.52) and time to progression (R = + 0.76). Nine patients with receptor-rich tumours (> 100 fmol/mg protein) failed to show a response. However, the percentage of cells staining for ER by ER-ICA assay was much more strongly related to the likelihood of response (R = + 0.89); no patient with < 20% cells staining responded. Wedge biopsy and the biochemical determination of ER activity is of limited value in predicting the likely response to tamoxifen; ER-ICA assays on such tumours may be more informative.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Anderson E. D., Forrest A. P., Levack P. A., Chetty U., Hawkins R. A. Response to endocrine manipulation and oestrogen receptor concentration in large operable primary breast cancer. Br J Cancer. 1989 Aug;60(2):223–226. doi: 10.1038/bjc.1989.256. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bates T., Riley D. L., Houghton J., Fallowfield L., Baum M. Breast cancer in elderly women: a Cancer Research Campaign trial comparing treatment with tamoxifen and optimal surgery with tamoxifen alone. The Elderly Breast Cancer Working Party. Br J Surg. 1991 May;78(5):591–594. doi: 10.1002/bjs.1800780523. [DOI] [PubMed] [Google Scholar]
  3. Davies N., Moir G., Carpenter R., Cuthbert A., Herbert A., Royle G. T., Taylor I. ERICA predicts response to tamoxifen in elderly women with breast cancer. Ann R Coll Surg Engl. 1991 Nov;73(6):361–363. [PMC free article] [PubMed] [Google Scholar]
  4. Forrest A. P., Anderson E. D., Gaskill D. Primary systemic therapy for breast cancer. Br Med Bull. 1991 Apr;47(2):357–371. doi: 10.1093/oxfordjournals.bmb.a072476. [DOI] [PubMed] [Google Scholar]
  5. Furr B. J., Jordan V. C. The pharmacology and clinical uses of tamoxifen. Pharmacol Ther. 1984;25(2):127–205. doi: 10.1016/0163-7258(84)90043-3. [DOI] [PubMed] [Google Scholar]
  6. Gaskell D. J., Hawkins R. A., Sangsterl K., Chetty U., Forrest A. P. Relation between immunocytochemical estimation of oestrogen receptor in elderly patients with primary breast cancer and response to tamoxifen. Lancet. 1989 May 13;1(8646):1044–1046. doi: 10.1016/s0140-6736(89)92445-8. [DOI] [PubMed] [Google Scholar]
  7. Hawkins R. A., Black R., Steele R. J., Dixon J. M., Forrest A. P. Oestrogen receptor concentration in primary breast cancer and axillary node metastases. Breast Cancer Res Treat. 1981;1(3):245–251. doi: 10.1007/BF01806264. [DOI] [PubMed] [Google Scholar]
  8. Hawkins R. A., Hill A., Freedman B. A simple method for the determination of oestrogen receptor concentrations in breast tumours and other tissues. Clin Chim Acta. 1975 Oct 15;64(2):203–210. doi: 10.1016/0009-8981(75)90202-8. [DOI] [PubMed] [Google Scholar]
  9. Hawkins R. A. Receptors in the management of breast cancer. Br J Hosp Med. 1985 Sep;34(3):160–164. [PubMed] [Google Scholar]
  10. Hawkins R. A., Sangster K., Tesdale A., Levack P. A., Anderson E. D., Chetty U., Forrest A. P. The cytochemical detection of oestrogen receptors in fine needle aspirates of breast cancer; correlation with biochemical assay and prediction of response to endocrine therapy. Br J Cancer. 1988 Jul;58(1):77–80. doi: 10.1038/bjc.1988.166. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Horobin J. M., Preece P. E., Dewar J. A., Wood R. A., Cuschieri A. Long-term follow-up of elderly patients with locoregional breast cancer treated with tamoxifen only. Br J Surg. 1991 Feb;78(2):213–217. doi: 10.1002/bjs.1800780228. [DOI] [PubMed] [Google Scholar]
  12. Hähnel R., Woodings T., Vivian A. B. Prognostic value of estrogen receptors in primary breast cancer. Cancer. 1979 Aug;44(2):671–675. doi: 10.1002/1097-0142(197908)44:2<671::aid-cncr2820440238>3.0.co;2-v. [DOI] [PubMed] [Google Scholar]
  13. Steele R. J., Hawkins R. A., Anderson T. J., Forrest A. P. The relevance of control histology in oestrogen receptor estimation. Br J Cancer. 1987 Nov;56(5):617–618. doi: 10.1038/bjc.1987.252. [DOI] [PMC free article] [PubMed] [Google Scholar]

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