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. 1993 Sep;69(815):701–703. doi: 10.1136/pgmj.69.815.701

Restless legs syndrome in the elderly.

S T O'Keeffe 1, J Noel 1, J N Lavan 1
PMCID: PMC2399773  PMID: 8255834

Abstract

The prevalence and significance of restless legs syndrome was assessed in 307 patients presenting to an acute-care geriatric medical service. Fifteen patients (5%) had restless legs syndrome; 13 (87%) of these patients had insomnia and 10 (67%) reported troublesome or frequent leg symptoms. Of 147 patients with current insomnia, iron deficiency (serum ferritin < 18 ng/ml) was present in 4/13 (31%) patients with restless legs and 8/134 (6%) patients without restless legs (P < 0.025). Improvement in symptoms of restless legs was noted with iron repletion. These findings suggest that restless legs syndrome is relatively common in the elderly and causes significant discomfort and sleep disturbance. Iron deficiency is a common and treatable cause.

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Selected References

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  1. Banerji N. K., Hurwitz L. J. Restless legs syndrome, with particular reference to its occurrence after gastric surgery. Br Med J. 1970 Dec 26;4(5738):774–775. doi: 10.1136/bmj.4.5738.774. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barnes T. R., Braude W. M. Akathisia variants and tardive dyskinesia. Arch Gen Psychiatry. 1985 Sep;42(9):874–878. doi: 10.1001/archpsyc.1985.01790320042006. [DOI] [PubMed] [Google Scholar]
  3. Ben-Shachar D., Finberg J. P., Youdim M. B. Effect of iron chelators on dopamine D2 receptors. J Neurochem. 1985 Oct;45(4):999–1005. doi: 10.1111/j.1471-4159.1985.tb05514.x. [DOI] [PubMed] [Google Scholar]
  4. Botez M. I., Lambert B. Folate deficiency and restless-legs syndrome in pregnancy. N Engl J Med. 1977 Sep 22;297(12):670–670. doi: 10.1056/NEJM197709222971220. [DOI] [PubMed] [Google Scholar]
  5. Brown K. W., Glen S. E., White T. Low serum iron status and akathisia. Lancet. 1987 May 30;1(8544):1234–1236. doi: 10.1016/s0140-6736(87)92687-0. [DOI] [PubMed] [Google Scholar]
  6. Callaghan N. Restless legs syndrome in uremic neuropathy. Neurology. 1966 Apr;16(4):359–361. doi: 10.1212/wnl.16.4.359. [DOI] [PubMed] [Google Scholar]
  7. EKBOM K. A. Restless legs syndrome. Neurology. 1960 Sep;10:868–873. doi: 10.1212/wnl.10.9.868. [DOI] [PubMed] [Google Scholar]
  8. Gillin J. C., Byerley W. F. Drug therapy: The diagnosis and management of insomnia. N Engl J Med. 1990 Jan 25;322(4):239–248. doi: 10.1056/NEJM199001253220406. [DOI] [PubMed] [Google Scholar]
  9. Guyatt G. H., Patterson C., Ali M., Singer J., Levine M., Turpie I., Meyer R. Diagnosis of iron-deficiency anemia in the elderly. Am J Med. 1990 Mar;88(3):205–209. doi: 10.1016/0002-9343(90)90143-2. [DOI] [PubMed] [Google Scholar]
  10. Impallomeni M., Kenny R. A., Flynn M. D., Kraenzlin M., Pallis C. A. The elderly and their ankle jerks. Lancet. 1984 Mar 24;1(8378):670–672. doi: 10.1016/s0140-6736(84)92181-0. [DOI] [PubMed] [Google Scholar]
  11. Krueger B. R. Restless legs syndrome and periodic movements of sleep. Mayo Clin Proc. 1990 Jul;65(7):999–1006. doi: 10.1016/s0025-6196(12)65163-5. [DOI] [PubMed] [Google Scholar]
  12. Mosko S., Zetin M., Glen S., Garber D., DeAntonio M., Sassin J., McAnich J., Warren S. Self-reported depressive symptomatology, mood ratings, and treatment outcome in sleep disorders patients. J Clin Psychol. 1989 Jan;45(1):51–60. doi: 10.1002/1097-4679(198901)45:1<51::aid-jclp2270450107>3.0.co;2-h. [DOI] [PubMed] [Google Scholar]
  14. Roehrs T., Zorick F., Sicklesteel J., Wittig R., Roth T. Age-related sleep-wake disorders at a sleep disorder center. J Am Geriatr Soc. 1983 Jun;31(6):364–370. doi: 10.1111/j.1532-5415.1983.tb05748.x. [DOI] [PubMed] [Google Scholar]
  15. Sandyk R. The restless legs syndrome (Ekbom's syndrome). S Afr Med J. 1983 Apr 30;63(18):701–702. [PubMed] [Google Scholar]
  16. Simon R. Confidence intervals for reporting results of clinical trials. Ann Intern Med. 1986 Sep;105(3):429–435. doi: 10.7326/0003-4819-105-3-429. [DOI] [PubMed] [Google Scholar]
  17. Strang R. R. The symptom of restless legs. Med J Aust. 1967 Jun 17;1(24):1211–1213. doi: 10.5694/j.1326-5377.1967.tb73929.x. [DOI] [PubMed] [Google Scholar]
  18. Walters A. S., Hening W. Clinical presentation and neuropharmacology of restless legs syndrome. Clin Neuropharmacol. 1987 Jun;10(3):225–237. doi: 10.1097/00002826-198706000-00004. [DOI] [PubMed] [Google Scholar]
  19. Zorick F. J., Roth T., Hartze K. M., Piccione P. M., Stepanski E. J. Evaluation and diagnosis of persistent insomnia. Am J Psychiatry. 1981 Jun;138(6):769–773. doi: 10.1176/ajp.138.6.769. [DOI] [PubMed] [Google Scholar]

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