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. 1984 May;47(5):1023–1026. doi: 10.1128/aem.47.5.1023-1026.1984

Membrane ultrafiltration: concentration of interleukin-3.

F Klein, R T Ricketts, T R Rohrer, W I Jones Jr, P M Clark, M C Flickinger
PMCID: PMC240045  PMID: 6430227

Abstract

A pilot-plant-scale operation was used for studying membrane ultrafiltration and concentration of kiloliter quantities of the lymphokine interleukin-3 with a single set of membranes. Initial use of ammonium sulfate precipitation of interleukin-3 proved erratic in the recovery of biological activity and resulted in corrosion of the processing equipment. Membrane ultrafiltration proved to be effective in enabling control of the degree of concentration and predicting recovery of the biologically active protein.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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