Skip to main content
Journal of Virology logoLink to Journal of Virology
. 1993 Apr;67(4):2344–2348. doi: 10.1128/jvi.67.4.2344-2348.1993

Passive antibody protection of cats against feline immunodeficiency virus infection.

T Hohdatsu 1, R Pu 1, B A Torres 1, S Trujillo 1, M B Gardner 1, J K Yamamoto 1
PMCID: PMC240393  PMID: 8383246

Abstract

All six cats passively immunized with sera from either feline immunodeficiency virus (FIV)-vaccinated cats or cats infected with FIV (Petaluma strain) were protected from homologous FIV infection at a challenge dose that infected all six control cats. Passive immunization with sera from cats vaccinated with uninfected allogeneic T cells used to grow the vaccine virus did not protect either of two cats against the same FIV challenge. These results suggest that antiviral humoral immunity, perhaps in synergy with anticellular antibodies, may be responsible for previously reported vaccine protection.

Full text

PDF
2345

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cranage M. P., Ashworth L. A., Greenaway P. J., Murphey-Corb M., Desrosiers R. C. AIDS vaccine developments. Nature. 1992 Feb 20;355(6362):685–686. doi: 10.1038/355685a0. [DOI] [PubMed] [Google Scholar]
  2. Egberink H. F., Hartman K., Horzinek M. C. Chemotherapy of feline immunodeficiency virus infection. J Am Vet Med Assoc. 1991 Nov 15;199(10):1485–1487. [PubMed] [Google Scholar]
  3. Emini E. A., Schleif W. A., Nunberg J. H., Conley A. J., Eda Y., Tokiyoshi S., Putney S. D., Matsushita S., Cobb K. E., Jett C. M. Prevention of HIV-1 infection in chimpanzees by gp120 V3 domain-specific monoclonal antibody. Nature. 1992 Feb 20;355(6362):728–730. doi: 10.1038/355728a0. [DOI] [PubMed] [Google Scholar]
  4. Gardner M. B. Simian and feline immunodeficiency viruses: animal lentivirus models for evaluation of AIDS vaccines and antiviral agents. Antiviral Res. 1991 May;15(4):267–286. doi: 10.1016/0166-3542(91)90009-g. [DOI] [PubMed] [Google Scholar]
  5. Hosie M. J., Robertson C., Jarrett O. Prevalence of feline leukaemia virus and antibodies to feline immunodeficiency virus in cats in the United Kingdom. Vet Rec. 1989 Sep 9;125(11):293–297. doi: 10.1136/vr.125.11.293. [DOI] [PubMed] [Google Scholar]
  6. Jackson G. G., Perkins J. T., Rubenis M., Paul D. A., Knigge M., Despotes J. C., Spencer P. Passive immunoneutralization of human immunodeficiency virus in patients with advanced AIDS. Lancet. 1988 Sep 17;2(8612):647–652. doi: 10.1016/s0140-6736(88)90468-0. [DOI] [PubMed] [Google Scholar]
  7. Jarrett O., Yamamoto J. K., Neil J. C. Feline immunodeficiency virus as a model for AIDS vaccination. AIDS. 1990;4 (Suppl 1):S163–S165. [PubMed] [Google Scholar]
  8. Karpas A., Hewlett I. K., Hill F., Gray J., Byron N., Gilgen D., Bally V., Oates J. K., Gazzard B., Epstein J. E. Polymerase chain reaction evidence for human immunodeficiency virus 1 neutralization by passive immunization in patients with AIDS and AIDS-related complex. Proc Natl Acad Sci U S A. 1990 Oct;87(19):7613–7617. doi: 10.1073/pnas.87.19.7613. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Kempf C., Jentsch P., Barre-Sinoussi F. B., Poirier B., Morgenthaler J. J., Morell A., Germann D. Inactivation of human immunodeficiency virus (HIV) by low pH and pepsin. J Acquir Immune Defic Syndr. 1991;4(8):828–830. [PubMed] [Google Scholar]
  10. Povey R. C., Hawkins G. J. Feline immunodeficiency virus: A commentary. Can Vet J. 1989 Jul;30(7):559–562. [PMC free article] [PubMed] [Google Scholar]
  11. Prince A. M., Reesink H., Pascual D., Horowitz B., Hewlett I., Murthy K. K., Cobb K. E., Eichberg J. W. Prevention of HIV infection by passive immunization with HIV immunoglobulin. AIDS Res Hum Retroviruses. 1991 Dec;7(12):971–973. doi: 10.1089/aid.1991.7.971. [DOI] [PubMed] [Google Scholar]
  12. Putkonen P., Thorstensson R., Ghavamzadeh L., Albert J., Hild K., Biberfeld G., Norrby E. Prevention of HIV-2 and SIVsm infection by passive immunization in cynomolgus monkeys. Nature. 1991 Aug 1;352(6334):436–438. doi: 10.1038/352436a0. [DOI] [PubMed] [Google Scholar]
  13. Stott E. J. Anti-cell antibody in macaques. Nature. 1991 Oct 3;353(6343):393–393. doi: 10.1038/353393a0. [DOI] [PubMed] [Google Scholar]
  14. Theilen G. H., Kawakami T. G., Rush J. D., Munn R. J. Replication of cat leukemia virus in cell suspension cultures. Nature. 1969 May 10;222(5193):589–590. doi: 10.1038/222589b0. [DOI] [PubMed] [Google Scholar]
  15. Vittecoq D., Mattlinger B., Barre-Sinoussi F., Courouce A. M., Rouzioux C., Doinel C., Bary M., Viard J. P., Bach J. F., Rouger P. Passive immunotherapy in AIDS: a randomized trial of serial human immunodeficiency virus-positive transfusions of plasma rich in p24 antibodies versus transfusions of seronegative plasma. J Infect Dis. 1992 Feb;165(2):364–368. doi: 10.1093/infdis/165.2.364. [DOI] [PubMed] [Google Scholar]
  16. Yamamoto J. K., Ackley C. D., Zochlinski H., Louie H., Pembroke E., Torten M., Hansen H., Munn R., Okuda T. Development of IL-2-independent feline lymphoid cell lines chronically infected with feline immunodeficiency virus: importance for diagnostic reagents and vaccines. Intervirology. 1991;32(6):361–375. doi: 10.1159/000150220. [DOI] [PubMed] [Google Scholar]
  17. Yamamoto J. K., Hansen H., Ho E. W., Morishita T. Y., Okuda T., Sawa T. R., Nakamura R. M., Pedersen N. C. Epidemiologic and clinical aspects of feline immunodeficiency virus infection in cats from the continental United States and Canada and possible mode of transmission. J Am Vet Med Assoc. 1989 Jan 15;194(2):213–220. [PubMed] [Google Scholar]
  18. Yamamoto J. K., Hohdatsu T., Olmsted R. A., Pu R., Louie H., Zochlinski H. A., Acevedo V., Johnson H. M., Soulds G. A., Gardner M. B. Experimental vaccine protection against homologous and heterologous strains of feline immunodeficiency virus. J Virol. 1993 Jan;67(1):601–605. doi: 10.1128/jvi.67.1.601-605.1993. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Yamamoto J. K., Okuda T., Ackley C. D., Louie H., Pembroke E., Zochlinski H., Munn R. J., Gardner M. B. Experimental vaccine protection against feline immunodeficiency virus. AIDS Res Hum Retroviruses. 1991 Nov;7(11):911–922. doi: 10.1089/aid.1991.7.911. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Virology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES